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New England Patriots vs Buffalo Bills Predictions, Odds and Best Bets for Week 15 NFL 2025-26 Season

Eric Divakaran
American Football / NFL
14/12/2025 – 19:00
New England Patriots
VS
19:00
14/12/2025
Buffalo Bills
Odds updated on December 11, 2025 at 10:03 pm

The New England Patriots host the Buffalo Bills for an exciting Sunday matchup between two elite teams. This Patriots vs Bills matchups features two elite teams battling it out the second this season in an AFC East showdown.

The Patriots have been amazing this season, being undefeated on the road and currently own a 10-game win streak, tied with the Broncos for the best record in the NFL. Coach Mike Vrabel has led this team to a historic season, alongside Drake Maye, who could be crowed the MVP this season. Going up against the Bills for the second time, another win would send the rest of the league a clear message, that they are ready for the postseason.

Meanwhile, the Bills have won three games in a row and are right behind the Patriots at AFC East. This is the second time the Bills face the Patriots and Josh Allen and the Bills need to close out their season strong, to keep their momentum going into the playoffs. This season is the best chance for the Bills to win a Super Bowl and it starts by beating arguably the best team in the NFL currently.

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Recommended Bets and Updated Odds

Recommended BetsFanduelBetMGM
Josh Allen Over 0.5 interceptions-114+100
James Cook under 80.5 rushing yards -114-110
Rhamondre Stevenson over 10.5 rushing attempts-132-105
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Rationale and Analysis

Josh Allen has thrown 10 interceptions this season, with six interceptions in his last five games. The last time he played the Patriots this season, he threw a pick and looking at the Patriots defense that is ranked No.1 in rushing, potentially shutting down the Bills’ rushing attack, making Allen throw more attempts, possibly leading to an interception.

The Patriots are the No.1 rush defense team in the NFL allowing only 84.7 yards a game and 4 TDs this season. They effectively shut down the Pats’ rushing offense the last time these two teams squared off and forced James Cook into a terrible game, in otherwise what has been a great season. He dropped only 49 yards against the Pats in their last outing and we believe the same will happen in this game.

The reason that the Bills are not leading the AFC East has been because of the downright terrible rushing defense that’ve shown this season. On too many occasions they have let their opposition explode with a rushing attack and have 17 rush TDs scored against them (league worst). Looking at this we believe that Rhamondre Stevenson will get over 10.5 rushing attempts in this game, with the Pats potentially leading a run-heavy approach.

Patriots vs Bills Prediction

We expect the Patriots to pull another upset tonight and walk away with a W. As great as the Bills are, they simple can be shut down because of the Patriots excellent scoring, rushing, and overall defense. Also Buffalo lost to the Patriots earlier this season, at their home, handing them the only loss they’ve taken at home this season. With this game being on the Patriots’ home ground and a 10-game win streak, we are picking a New England team that nobody has answers for.

Prediction: Patriots win the game 27-24

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Week 15 Patriots vs Bills Spread and Betting Odds

Looking at the spread and the moneyline, the Bills are only a slight favorite to win against the Patriots, as per BetMGM.

TeamsSpreadTotal PointsMoneyline
Bills-1 (-110)49.5 (-110)-115
Patriots+1 (-110)49.5 (-110)-105
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Patriots vs Bills Best Bets

Here are some of the best player bets and over/under odds for the New England Patriots and the Buffalo Bills, as per BetMGM.

New England Patriots Over/Under Odds

Listed below are over/under odds for the New England Patriots, as per BetMGM.

Over/Under BetsOverUnder
Drake Maye passing yards231.5 (-115)231.5 (-115)
TreVeyon Henderson rushing yards45.5 (-115)45.5 (-115)
Stefon Diggs receiving yards50.5 (-110)50.5 (-118)

New England Patriots Best Player Bets

Here are some of the best player for the New England Patriots, as per BetMGM.

  • TreVeyon Henderson anytime TD scorer: -115
  • Drake Maye over 1.5 passing TDs: -150
  • Rhamondre Stevenson over 10.5 rushing attempts: -105

Buffalo Bills Over/Under Odds

Listed below are over/under odds for the Buffalo Bills, as per BetMGM.

Over/Under BetsOverUnder
James Cook rushing yards 80.5 (-118)80.5 (-110)
Josh Allen passing yards 230.5 (-115)230.5 (-115)
Dalton Kincaid receiving yards 42.5 (-115)42.5 (-115)

Buffalo Bills Best Player Bets

Here are some of the best player bets for the Buffalo Bills, as per BetMGM.

  • James Cook under 19.5 rushing attempts: -135
  • Josh Allen over 0.5 interceptions thrown: +100
  • Khalil Shakir over 4.5 receptions made: +105
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(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

FAQs

Who is favored to win between the Patriots vs Bills?
The Bills are 1-point favorites to win the matchup against Patriots.

What is the over/under total for the game?
The over/under for total points is set at 49.5.

What is the predicted score for the Patriots vs Bills game?
We expect the Patriots to take down the Bills, and the Final score to be 27-24.

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I cover the National Football League and things cannot get better than that. I always dreamed to play football or basketball professionally since I’m built like a Running Back. But now that I can’t, since I’m technically in the “Unc” age, I thought why not pick a career in sports industry? So here I am, doing what I love, and hoping that the Commanders win the Super Bowl. I give love to players when it’s due, but can be critical about their performances at the same time. Enough about me, now let my articles do all the talking. 

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