Panthers vs Buccaneers Predictions, Odds and Best Bets For Week 16 of the 2025-26 NFL Season

The final few weeks of the NFL regular season are here, and with that, there is plenty of excitement in the air. Week 16 of this football season brings us an all-NFC South clash as the Tampa Bay Buccaneers travel north to take on the Carolina Panthers.

This contest should be an intense one, considering the magnitude of what is at stake. Both teams come into this game with a 7-7 record, as the Bucs hold the tie-break advantage over the Panthers as we draw closer to the postseason.

Game Details:

Time: 1:00 p.m. ET
Date: Sunday, December 14, 2025
Location: Bank of America Stadium, Charlotte, North Carolina
TV Channel: FOX
Streaming: Fubo, NFL Sunday Ticket on YouTube, NFL+

𝐁𝐚𝐜𝐤 @ 𝐇𝐨𝐦𝐞.💙
The Carolina Panthers Small Business Partners would like to wish the team all the best ahead of this weekend's game!

We'll be backing you all the way. 👊#Partnerships #Community #Panthers #KeepPounding #NCBusiness pic.twitter.com/ndCahVNQha
— Carolina Panthers Small Business Partnership (@PanthersSBP) December 19, 2025

Recommended bets and updated odds

Recommended Bets	FanDuel	BetMGM
Bryce Young Over 1.5 Passing Touchdowns	+112	+118
Mike Evans Overs 4.5 Receptions	+104	+100
Baker Mayfield Over 0.5 Interceptions	-102	-104

Analysis and Rationale

Bryce Young has been on a tear recently when it comes to passing touchdowns. In the last 4 games, Young has thrown 8 touchdowns. Moreover, the Buccaneers have a much better run defense as opposed to their pass defense, ranking 30th in passing yards allowed, giving up 24 passing touchdowns in 14 games.

Buccaneers’ wide receiver made a massive impact after returning from injury in the last game as Tampa Bay’s offense looked more like what it was at the start of the season. Evans is one of the primary targets for Baker Mayfield and has caught 4 or more passes in 4 of the 5 games he has played this season. He missed out against the Lions, but that was also the same game where he had only 4 targets and left the game early due to an injury.

The Carolina Panthers’ defense sits mid-tier with 12 interceptions from 14 games. Baker Mayfield has thrown just 7 picks this season, but 5 of those have come in the last 5 games. In fact, he has thrown at least one interception in 4 of those 5 games.

Panthers vs Buccaneers Prediction

The Panthers vs Buccaneers Week 16 encounter is a crucial one with significant ramifications for the upcoming postseason. With both teams having an equal 7-7 record, the Bucs are ahead only on the tiebreaker.

The Buccaneers may have lost their last game against the Falcons, but with Mike Evans back in the lineup, the offense saw a big difference. The Panthers have already exceeded expectations for this season, and they had a chance to take the lead in the division, but lost to division rivals, the New Orleans Saints.

Prediction: Tampa Bay Buccaneers to win.

Week 16 Panthers vs Buccaneers Betting Odds and Spread

The moneyline and spread show the Tampa Bay Buccaneers are slight favorites in this matchup against the Carolina Panthers. (Sourced from FanDuel).

	Moneyline	Spread	Total Points
Carolina Panthers	+136	+3 (-110)	O 45.5 (-110)
Tampa Bay Buccaneers	-162	-3 (-110)	U 45.5 (-110)

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Panthers vs Buccaneers Best Bets

Here are the over/under and best player bets for the Carolina Panthers and the Tampa Bay Buccaneers, as per FanDuel.

Carolina Panthers Over/Under Odds

Below are some of the best over/under bets for the Carolina Panthers.

Over/ Under Bets	Over	Under
Bryce Young Passing Yards	30.5 (-106)	30.5 (-122)
Tetairoa McMillan Total Receptions	4.5 (-114)	4.5 (-114)
Chuba Hubbard Rush Attempts	8.5 (-136)	8.5 (+102)

Carolina Panthers Best Player Bets

Below are some of the best player bets for the Carolina Panthers.

Bryce Young 175+ Passing Yards: -250
Jalen Coker 30+ Receiving Yards: -188
Rico Dowdle 50+ Rushing Yards: -192

If you’re looking for a complete guide to the best NFL betting sites, we’ve got you covered

A can't-miss division battle 👀 pic.twitter.com/pEkbY9Y9gq
— Tampa Bay Buccaneers (@Buccaneers) December 18, 2025

Tampa Bay Buccaneers Over/Under Odds

Below are some of the best over/under bets for the Tampa Bay Buccaneers.

Over/ Under Bets	Over	Under
Baker Mayfield Pass Attempts	31.5 (-120)	31.5 (-108)
Mike Evans Total Receptions	4.5 (+104)	4.5 (-138)
Bucky Irving Rush Attempts	16.5 (-114)	16.5 (-114)

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Tampa Bay Buccaneers Best Player Bets

Below are some of the best player bets for the Tampa Bay Buccaneers.

Baker Mayfield 225+ Passing Yards: -130
Emeka Egbuka Over 3.5 Receptions: +112
Bucky Irving Over 64.5 Rushing Yards: -114

The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

FAQs

What is the over/under for total points for the Panthers vs Buccaneers game?

The over/under for total points in the Panthers vs Buccaneers game is set at 46.5.

What is the point spread for the Panthers vs Buccaneers game?

The Buccaneers come into the game as 3-point favorites over the Panthers.

What is the moneyline for the Panthers vs Buccaneers game?

The Buccaneers are the favorites with a moneyline of -162, while the Panthers are the underdogs at +136.

Mandatory Credit: Matthew Hinton-Imagn Images

Devavrat Kulkarni

nfl

I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!