Aug 29, 2025; Flushing, NY, USA; Novak Djokovic (SRB) after beating Cameron Norrie (GBR) (not pictured) on day six of the 2025 U.S. Open tennis tournament at the USTA Billie Jean King National Tennis Center. Mandatory Credit: Robert Deutsch-Imagn Images

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Novak Djokovic vs. Jan-Lennard Struff Head-to-Head, Predictions and Betting Odds for US Open 2025 Round of 16

Can the Serbian keep his Grand Slam dream alive?

Novak Djokovic will continue his pursuit of a record-breaking 25th Grand Slam, as he faces Jan-Lennard Struff in the 2025 US Open Round of 16. It certainly hasn’t been a smooth and electric outing for Djokovic so far. Although he cruised into Round-2, the Serbian icon was forced to dig deep to jump over his next two hurdles. However, the former No. 1 is slowly regaining his usual swagger with every passing contest.

Jan-Lennard Struff, on the other hand, is going through an unexpected run. The German qualifier has already defeated two seeded players in this event. His win against 2024 semi-finalist Frances Tiafoe, in particular, was a massive confidence boosting win. He has the serve to trouble any top player in the world; however, a lot will depend on his ability to sustain a high level during neutral rallies. As two veterans aged 35+ lock horns, let’s take a look at the predictions and odds for this match – from BetMGM.

Novak Djokovic vs. Jan-Lennard Struff Head to Head

Novak Djokovic leads Jan-Lennard Struff 7-0 in their head-to-head record.

Struff has barely come close to beating Djokovic in any of their previous matches. In fact, apart from the 2020 Australian Open, Djoker has always beaten Struff in straight sets. As a result, the odds are really stacked against Struff ahead of the US Open pre-quarterfinal.

Year	Event	Round	Winner	Score
2021	Davis Cup	Round Robin	Novak Djokovic	6-2, 6-4
2021	Tokyo	Round of 32	Novak Djokovic	6-4, 6-3
2020	US Open	Round of 32	Novak Djokovic	6-3, 6-3, 6-1
2020	Cincinnati	Quarterfinals	Novak Djokovic	6-3, 6-1
2020	Australian Open	Round of 128	Novak Djokovic	7-6(5), 6-2, 2-6, 6-1
2019	Roland Garros	Round of 16	Novak Djokovic	6-3, 6-2, 6-2
2017	Doha	Round of 32	Novak Djokovic	7-6(1), 6-3

Novak Djokovic vs. Jan-Lennard Struff Career Comparison

Novak Djokovic	Category	Jan-Lennard Struff
7	Current Rank	144
26/9	YTD W/L	9/18
1	YTD Titles	0
1150/231	Career W/L	231/260
100	Career Titles	1

Novak Djokovic vs. Jan-Lennard Struff US Open 2025 Prediction

There is no doubt that Jan-Lennard Struff has punched above his weight at this year’s US Open. But against an opponent like Djokovic, the baseline firepower will be of extremely high importance. The Serb will target Struff’s backhand wing, and also mix up the pace to keep his German counterpart on the move. While we do sense that the match could go beyond three sets, it is unlikely that the qualifier will upset the odds.

Prediction: Novak Djokovic in four sets.

Another electric night on Ashe. Bright lights, loud music, rap royalty in the crowd. Few tough moments but NYC your energy got me through 🙌. Time to Lean Back 😆 then forward to R4. pic.twitter.com/hbypF7o3M2
— Novak Djokovic (@DjokerNole) August 30, 2025

Novak Djokovic vs. Jan-Lennard Struff US Open 2025 Betting Odds

Djokovic is a big favorite heading into this match per the data given by BetMGM.

Novak Djokovic win – 3/20
Jan-Lennard Struff win – 17/4

Total Sets 2 – 17/20
Total Sets 3 – 19/10
Total Games >35.5 – 77/100
Total Games <35.5 – 91/100
Set 1 Winner Djokovic – 33/100
Set 1 Winner Struff – 11/5

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals, and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

Mandatory Credit: Robert Deutsch-Imagn Images

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Sanskar Dubey

A passionate sports fan since childhood, it was always my dream to cover the peak of human potential. Baseball, Tennis, and Football (or Soccer) have been closest to my heart. From Rafael Nadal’s never-say-die attitude to Roger Federer’s beautiful backhand, I’ve seen it all. Prior to the Playoffs, I’ve worked in EssentiallySports and Pro Football and Sports Network.