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NFL Wild Card Round 2025-26 Opening Odds and Betting Lines

Devavrat Kulkarni

6 Wild Card games spread over 3 days as the NFL postseason gets underway!

The NFL playoffs are finally here, and we have the exciting Wild Card round to look forward to. At the end of the regular season, the Denver Broncos and the Seattle Seahawks clinched the number one seed for the AFC and NFC, respectively. 

That means we are left with 12 teams looking to progress to the Divisional round of the playoffs, providing us with some intense matchups. From the AFC, the Patriots host the Chargers, the Jaguars host the Bills, and the Steelers host the Texans, whereas the Rams visit the Panthers, the Packers take on divisional rival Bears, and the 49ers head east to play the Eagles.  

So, without further ado, let us take a look at what the markets show as their opening odds and betting lines for the upcoming slate of games this weekend. 

NFL Wild Card Round Opening Odds and Betting Lines

Now that the NFL Wild Card round is set for the 2025-26 NFL season, we take a look at the opening odds and the betting lines for all 6 games coming up this weekend (sourced via FanDuel). 

Matchup Opening SpreadOpening MoneylineOpening Total (O/U)
Los Angeles Rams at Carolina PanthersRams -10.5 (-105Rams -620 / Panthers +46046.5
Green Bay Packers at Chicago BearsPackers -1.5 (-105)Packers -116 / Bears -10245.5
Buffalo Bills at Jacksonville JaguarsBills -1.5 (-102)Bills -108 / Jaguars -10852.5
San Francisco 49ers at Philadelphia EaglesEagles -4.5 (-110)49ers +184 / Eagles -22044.5
Los Angeles Chargers at New England PatriotsPatriots -3.5 (-110)Chargers +164 / Patriots -19646.5
Houston Texans at Pittsburgh SteelersTexans -3 (-115)Texans -180 / Steelers +152 39.5

The above odds are opening numbers sourced via FanDuel and are accurate as of Wednesday, 1:00 a.m. ET. Lines may move before kickoff.

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If you’re looking for a complete guide to the best NFL betting sites, we’ve got you covered 

Biggest early favorites & totals

Looking at the early lines and odds for the Wild Card round, the following are the biggest early favorites based on the spread. 

  • The Los Angeles Rams are the biggest opening favorites at -10.5 over the Carolina Panthers.
  • The Philadelphia Eagles are the next big favorites at -4.5 against the San Francisco 49ers. 

With respect to the early totals, the following games are expected to be the highest and lowest-scoring games. 

  • The highest opening total is 52.5 for the Jaguars vs Bills AFC Wild Card game.
  • The lowest opening total is 39.5 for the Steelers vs Texans AFC Wild Card game.

Rams vs Panthers odds, spread & total (Saturday, 4:30 p.m. ET, FOX) 

  • Opening spread: Rams -10.5 (-105)
  • Opening moneyline: Rams -620, Panthers +460
  • Opening total: 46.5 O/U

The Rams head into this matchup against the Panthers as the clear favorites. Matthew Stafford is the big favorite to land the MVP this season and has been in exceptional form, while Puka Nacua has been his best weapon. Davante Adams is expected to be back for this game after missing multiple games due to injury. The Panthers have done well to make the playoffs, but their overall roster talent just doesn’t match up to the Rams. 

Packers vs Bears odds, spread & total (Saturday, 8:00 p.m. ET, Amazon Prime)

  • Opening spread: Packers -1.5 (-105)
  • Opening moneyline: Packers -116, Bears -102
  • Opening total: 45.5 O/U

It’s a divisional rivalry taking place for the third time this season. The two teams split the regular season record 1-1, and both teams ended their season with multiple consecutive losses. That said, the Bears have been the more consistent team, while the Packers have dealt with several injury issues, most notably to edge rusher Micah Parsons, who is out for the season.

Bills vs Jaguars odds, spread & total (Sunday, 1:00 p.m. ET, CBS)

  • Opening spread: Bills -1.5 (-102)
  • Opening moneyline: Bills -108, Jaguars -108
  • Opening total: 52.5 O/U

The Bills head to Jacksonville as the slight favorites despite the Jaguars 8-game win streak to close out the regular season. While the Jaguars are the team in better form, they haven’t played a top-caliber team for the past few weeks and lack postseason experience. The exact opposite holds true for the Bills. 

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49ers vs Eagles odds, spread & total (Sunday, 4:30 p.m. ET, FOX)

  • Opening spread: Eagles -4.5 (-110)
  • Opening moneyline: 49ers +184, Eagles -220
  • Opening total: 44.5 O/U

The 49ers taking on the Eagles is an exciting matchup, considering both teams have been strong contenders for the postseason on a regular basis. San Francisco has done well to get to the playoffs despite several injury woes. Fred Warner is still expected to miss the game, which is a massive loss for the 49ers. On the other hand, the Eagles have struggled offensively, but the reigning champions find ways to win, especially with their stellar defensive unit. 

Chargers vs Patriots odds, spread & total (Sunday, 8:00 p.m. ET, NBC)

  • Opening spread: Patriots -3.5 (-110)
  • Opening moneyline: Chargers +164, Patriots -196
  • Opening total: 46.5 O/U

The New England Patriots surprised many this season with the quick turnaround they have had under Mike Vrabel. Drake Maye is one of the contenders for the MVP, and the Patriots will hold home-field advantage with colder January weather being a factor against the Chargers. Los Angeles has done well despite losing several key starters along the way, but going up against New England on the road will be a challenge.

Texans vs Steelers odds, spread & total (Monday, 8:00 p.m. ET, ESPN/ABC)

  • Opening spread: Texans -3 (-115)
  • Opening moneyline: Texans -180, Steelers +152
  • Opening total: 39.5 O/U

Kudos to the Texans for hanging in despite a harsh start to their season. Houston is coming into this game with plenty of momentum after a 9-game win streak to end the regular season. The same cannot be said of the Steelers, though, as they have been anything but consistent. Nevertheless, the cold weather in Pittsburgh may be a factor for the visitors despite their favorite tag.

The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

Mandatory Credit: Mark Konezny-Imagn Images

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I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!

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