The Packers head into week 6 as massive favorites over the Browns!
By now, there is a clearer picture of how this NFL season is shaping up. Despite many teams falling in the middle of the pack, a few teams are starting to separate themselves at the top of the pack, while a few more are in a tough spot after just 5 weeks of football.
But as week 6 of the 2025-26 NFL season approaches, it is time to take a look at all the matchups for the week and the betting odds they carry. Before we delve into that, it is worth noting that the Texans and the Vikings will have their bye week in week 6.
Here are some of the best picks ahead of the full slate of week 6 games as per the odds on FanDuel.
The biggest point spread differential for the week 6 games is for the Packers vs Bengals game. Green Bay is a massive 14.5-point favorite over Cincinnati. The Packers are well rested after their bye week, while the Bengals suffered another heavy defeat to the Lions last week.
Other notable spreads include the Eagles and the Rams, who are both 7.5-point favorites over the Giants and the Ravens, respectively.
Green Bay is also a huge favorite over the Bengals with a -1200 line, while the Eagles and the Broncos have the next-best lines at -390 over the Giants and the Jets, respectively.
Let us now take a look at the betting odds as per FanDuel for all week 4 matchups, along with the predictions.
Week 6 starts with the Thursday Night Football (TNF) game between the Eagles and the Giants in what is perceived to be a complete mismatch of two teams. However, it is a divisional game, and anything can happen. The Eagles are coming off a horrid loss against the Broncos, while the Giants faced another loss to the Saints.
| Moneyline | Spread | Total Points | |
|---|---|---|---|
| Philadelphia Eagles | -390 | -7.5 (-106) | O 40.5 (-115) |
| New York Giants | +310 | +7.5 (-114) | U 40.5 (-105) |
Prediction: Eagles win and cover the spread.
Denver has started to play consistently well after the first couple of weeks. Last week was a huge morale-boosting win over the Eagles. As for the Jets, their terrible season continues as the only winless team in the league.
| Moneyline | Spread | Total Points | |
|---|---|---|---|
| Denver Broncos | -390 | -7 (-118) | O 43.5 (-112) |
| New York Jets | +310 | +7 (-104) | U 43.5 (-108) |
Prediction: Broncos to win.
Cleveland’s season continues to go downhill following its loss to Minnesota recently. At 1-4, the Browns have major struggles apart from the defense. Pittsburgh is coming off its bye week and should be raring to go in this divisional clash.
| Moneyline | Spread | Total Points | |
|---|---|---|---|
| Cleveland Browns | +210 | +5.5 (-122) | O 38.5 (-108) |
| Pittsburgh Steelers | -255 | -5.5 (-108) | U 38.5 (-112) |
Prediction: Steelers to win.
The Chargers are coming into week 6 with two losses in a row after a great 3-0 start, whereas the Dolphins are struggling to win games and have lost Tyreek Hill for the season.
| Moneyline | Spread | Total Points | |
|---|---|---|---|
| Los Angeles Chargers | -220 | -4.5 (-115) | O 43.5 (-112) |
| Miami Dolphins | +188 | +4.5 (-105) | U 43.5 (-108) |
Prediction: Chargers to win.
New England seems to have found its identity under Mike Vrabel, and their recent win over the Bills was an emphatic statement. As for the Saints, they earned their first win of the season against the Giants last week.
| Moneyline | Spread | Total Points | |
|---|---|---|---|
| New England Patriots | -194 | -3.5 (-110) | O 45.5 (-115) |
| New Orleans Saints | +162 | +3.5 (-110) | U 45.5 (-105) |
Prediction: Patriots win and cover the spread.
This matchup between the Seahawks and the Jaguars promises to be an exciting one. Both teams are playing quality football, and even though Seattle has lost 2 games, they have come against other impressive teams.
| Moneyline | Spread | Total Points | |
|---|---|---|---|
| Seattle Seahawks | +100 | +1.5 (-115) | O 46.5 (-105) |
| Jacksonville Jaguars | -118 | -1.5 (-105) | U 46.5 (-115) |
Prediction: Seahawks to win.
After a solid 2-0 start, the Cardinals have now lost 3 in a row and don’t look like a team capable of going toe-to-toe with the top teams. The Colts, on the other hand, continue to build on their impressive start.
| Moneyline | Spread | Total Points | |
|---|---|---|---|
| Arizona Cardinals | +245 | +6.5 (-110) | O 47.5 (-105) |
| Indianapolis Colts | -300 | -6.5 (-110) | U 47.5 (-115) |
Prediction: Colts win and cover the spread.
This game would have been much more exciting had it not been for all the injuries and poor defensive form on Baltimore’s side. Sadly, that is not the case, and so the Rams are big favorites in this week 6 matchup.
| Moneyline | Spread | Total Points | |
|---|---|---|---|
| Los Angeles Rams | -370 | -7.5 (-105) | O 44.5 (-115) |
| Baltimore Ravens | +295 | +7.5 (-115) | U 44.5 (-105) |
Prediction: Rams win and cover the spread.
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A matchup between two teams that are struggling this season. Dallas did walk out of their previous game with a resounding 37-22 win over the Jets, whereas the Panthers fought it out for a 27-24 win over the Dolphins.
| Moneyline | Spread | Total Points | |
|---|---|---|---|
| Dallas Cowboys | -176 | -3.5 (-104) | O 49.5 (-108) |
| Carolina Panthers | +148 | +3.5 (-118) | U 49.5 (-112) |
Prediction: Cowboys win and cover the spread.
This game between two teams near the very bottom of the league provides a great opportunity for one of them to improve to 2-4 on the year. The Raiders may be the favorites, but the Titans are on a high following their come-from-behind win over the Cardinals last week.
| Moneyline | Spread | Total Points | |
|---|---|---|---|
| Tennessee Titans | +194 | +5.5 (-114) | O 41.5 (-108) |
| Las Vegas Raiders | -235 | -5.5 (-106) | U 41.5 (-112) |
Prediction: Raiders to win.
This game is a clash between two current heavyweights in the league. With all the injury problems, it is a wonder how the 49ers are at 4-1, but that just goes to show how well the team is set up. As for the Bucs, rookie wideout Emeka Egbuka continues to make waves.
| Moneyline | Spread | Total Points | |
|---|---|---|---|
| San Francisco 49ers | +130 | +3 (-115) | O 47.5 (-108) |
| Tampa Bay Buccaneers | -154 | -3 (-105) | U 47.5 (-112) |
Prediction: 49ers to win.
The Bengals’ struggles after the loss of Joe Burrow continue to haunt them with 3 losses in a row. On the other side, the Packers will be back after a week’s rest and should come through with an easy win.
| Moneyline | Spread | Total Points | |
|---|---|---|---|
| Cincinnati Bengals | +750 | +14.5 (-115) | O 44.5 (-104) |
| Green Bay Packers | -1200 | -14.5 (-105) | U 44.5 (-118) |
Prediction: Packers to win.
The Lions continue to build on a strong start after faltering in week 1. Detroit’s offense has put up plenty of points, while the Chiefs’ short run of 2 successive wins came to a halt in week 5 against the Jaguars.
| Moneyline | Spread | Total Points | |
|---|---|---|---|
| Detroit Lions | +118 | +2.5 (-112) | O 52.5 (-110) |
| Kansas City Chiefs | -138 | -2.5 (-108) | U 52.5 (-110) |
Prediction: Lions to win.
The Bills suffered their first loss of the season against the Patriots last week, but they have pulled off some excellent wins so far. Atlanta, though, is coming off a bye week and should be raring to go in this win.
| Moneyline | Spread | Total Points | |
|---|---|---|---|
| Buffalo Bills | -225 | -4.5 (-115) | O 49.5 (-115) |
| Atlanta Falcons | +188 | +4.5 (-105) | U 49.5 (-105) |
Prediction: Bills to win and cover the spread.
The Bears are starting to come into their own with 2 successive wins prior to their bye week in week 5. As for the Commanders, they are coming off a quality win over the Chargers, and Jayden Daniels is back under center, which is always a positive.
| Moneyline | Spread | Total Points | |
|---|---|---|---|
| Chicago Bears | +188 | +4.5 (-112) | O 49.5 (-120) |
| Washington Commanders | -225 | -4.5 (-108) | U 49.5 (-102) |
Prediction: Commanders to win.
Week 6 of the 2025-26 NFL season is all set to begin with the Philadelphia Eagles taking on the New York Giants on TNF. There are many more exciting matchups this week with intriguing storylines to keep an eye out for.
All of the above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!
Mandatory Credit: Jerome Miron-Imagn Images
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