Mandatory Credit: Kyle Terada-Imagn Images

NFL Week 5 Schedule for 2025-26 Season Feat. 49ers vs Rams , Seahawks vs Buccaneers, Chargers vs Commanders and More!

Mandatory Credit: Kyle Terada-Imagn Images

As Week 5 kicks off the NFL’s first by slate, anticipation builds for pivotal divisional clashes and cross-conference test that may reshape early standings. With four teams resting, the focus will now sharpen on underdogs seeking breakthroughs and frontrunners trying to guard their positions, with a action packed schedule coming up for this week.

Injuries have spoiled the 2025 season, sidelining stars across rosters and forcing adjustments that exposes depth issues in various teams. From torn ACLs to ankle sprains, and hamstring woes, players just have not been able to stay healthy. Injuries have disrupted offenses and defenses and it’s certainly not fun for the fans who’ve paid top dollars to only witness widespread absences.

While some teams have remained undefeated, there are teams who have not even won a game yet, with 0-4 records. And there are teams who’ve started 1-3 this season, possibly hurting their playoff chances already, going into week 5.

NFL 2025-26 Season Week 5 Schedule

Game	Venue	Kickoff Time	T.V Channel
Thursday, October 2, 2025
Rams vs 49ers	SoFi Stadium	8:15 p.m. ET	Prime Video
Sunday, October 5, 2025
Browns vs Vikings	Northumberland Development Project, London	9: 30 a.m. ET	NFL Network/NFL +
Ravens vs Texans	M&T Bank Stadium	1:00 p.m. ET	CBS
Panthers vs Dolphins	Bank of America Stadium	1:00 p.m. ET	CBS
Saints vs Giants	Caesars Superdome	1:00 p.m. ET	CBS
Eagles vs Broncos	Lincoln Financial Field	1:00 p.m. ET	FOX
Jets vs Cowboys	MetLife Stadium	1:00 p.m. ET	FOX
Colts vs Raiders	Lucas Oil Stadium	1:00 p.m. ET	FOX
Cardinals vs Titans	State Farm Stadium	4:05 p.m. ET	CBS
Seahawks vs Buccaneers	Lumen Field	4:05 p.m. ET	CBS
Chargers vs Commanders	SoFi Stadium	4:25 p.m. ET	FOX
Bengals vs Lions	Paycor Stadium	4:25 p.m. ET	FOX
Bills vs Patriots	Highmark Stadium	8:20 p.m. ET	NBC
Monday, October 6, 2025
Jaguars vs Chiefs	EverBank Stadium	8:15 p.m. ET	ABC/ESPN

* According to NFL’s official Website

NFL Week 5 Primetime Games

For NFL Week 5, the primetime games are as follow;

Thursday Night Football: The San Francisco 49ers will take on the Los Angeles Rams, 8:15 E.T, on Prime Video.

Sunday Night Football: The Buffalo Bills will take on the New England Patriots, 8:20 p.m. ET, live on NBC.

Monday Night Football; MNF features the Jacksonville Jaguar taking on the Kansas City Chiefs, 8:15 p.m. ET, live on ABC/ESPN.

NFL CHEAT SHEET for WEEK 5

Defense vs Position for each game

Data are from this season (Using “Per-game stats” on Pro Football Reference)

Teams on BYE: Falcons, Bears, Packers, and Steelers pic.twitter.com/c7vmDOxudT
— Charton (@itsCharton) September 30, 2025

Rams vs 49ers, Chargers vs Commanders, Seahawks vs Buccaneers, Set to be Eye Grabbing Contests of NFL Week 5

To kick off week 5, the 3-1 Los Angeles Rams will host the 3-1 San Francisco 49ers, in this Week’s Thursday Night Football action, which also happens to be a NFC West clash between two elite teams. The 49ers are coming off a loss against the Jacksonville Jaguars, after a terrific 3-0 start. While the Rams have won every single matchup, only losing to the Super Bowl champs, the Philadelphia Eagles. Both teams have offensive and defensive firepower, and this contest promises to be a thrilling one, where defense may ultimately decide the winner.

Mac Jones showed some comeback magic last time he suited up 🪄✨

👀 Do you believe he can lead the #49ers to a W vs the Rams on Thursday night? pic.twitter.com/UrufXqDSgD
— 49ers & NFL News 24/7 (@49ersSportsTalk) October 1, 2025

The Los Angeles Chargers will take on the Washington Commanders on Sunday 5, 2025, in this AFC West vs NFC East clash. The Chargers are coming off a very disappointing loss to the New York Giants, who had not won a game this season. While we still believe that the Chargers could be a playoff team, losing against the Giants has put a big question mark in their team, with many asking if they are for real, or if they just won games on luck. Meanwhile, the Commanders are coming off a loss against the Atlanta Falcons, making them 2-2 for this season. Washington has been off a slow start this season, however, their QB1 Jayden Daniels, and WR Terry McLaurin are trending towards playing in Week 5, hoping to turn their season around.

The Seattle Seahawks (3-1) will face the Tampa Bay Buccaneers (3-1) for a NFC West vs NFC South battle. The Seahawks on a three game winning streak beating the Cardinals in a close one 23-20, and blowing out the Saints, and getting a win against the Steelers. While the Bucs come into this matchup with a loss against against the reigning defending champs, the Philadelphia Eagles, while they put up a good fight, the Eagles beat them with a 25-31 score line.

Here's the schedule for Week 5 of the 2025-26 NFL Season! pic.twitter.com/LI4NTGS3Gk
— Trip (@tripnfl) September 30, 2025

With various exciting matches coming up soon, make sure to tune into all of Week 5’s matchup as things cannot get anymore exciting than this!

49ers vs Rams

Commanders vs Chargers

Lions vs Bengals

NFL

NFL week 5

NFL Week 5 Schedule

Eric Divakaran

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I cover the National Football League and things cannot get better than that. I always dreamed to play football or basketball professionally since I’m built like a Running Back. But now that I can’t, since I’m technically in the “Unc” age, I thought why not pick a career in sports industry? So here I am, doing what I love, and hoping that the Commanders win the Super Bowl. I give love to players when it’s due, but can be critical about their performances at the same time. Enough about me, now let my articles do all the talking.