NFL Week 16 Underdog Picks and ATS Best Bets

Heading into Week 16 of the 2025-26 NFL season, the battle between playoff-contending teams is starting to really heat up. It is now that time of the season when teams need to be at their best to make one final push for the postseason, but they may also be at a crossroads with all the injuries that have piled up over the previous weeks.

Nevertheless, there is no let-up now, and with the season on the line, every team is ready to fight tooth and nail, no matter whether they are the favorites or the underdogs. So, with that, let us take a look at some of our best ATS bets and NFL Week 16 underdog picks.

Our Top Underdog ATS Picks for Week 16

Here is a list of our top NFL Week 16 underdog picks and ATS best bets (Sourced via FanDuel).

Los Angeles Chargers (+2.5) at Dallas Cowboys
Chicago Bears (+1.5) vs Green Bay Packers
New England Patriots (+2.5) at Baltimore Ravens

Los Angeles Chargers (+2.5) at Dallas Cowboys

Line: Chargers +2.5 with (-112) odds at FanDuel

The 10-4 Chargers are currently in red-hot form, having won their last three games, including back-to-back wins over last year’s Super Bowl teams, the Eagles and Chiefs. Not only did the Chargers march into Arrowhead and end all hopes of a postseason run for KC, but they also did it in style.

What is highly impressive about this Chargers team is the fact that they have decent production on the offense despite missing key starting players at various positions, such as tackle and running back.

The AFC West franchise also has a top ten scoring defense, allowing just about 20 points a game, which is significantly less than the 31st-ranked Dallas Cowboys, giving up nearly 30 points a game. Moreover, the Cowboys are also the worst-ranked pass defense in the league and are tied for the most passing touchdowns allowed (31) through 15 weeks of football.

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“The Bears are gonna beat the Packers and it might not even matter if statistically Caleb Williams has a better game than Jordan Love. And I think he can. And I think he probably will.”
⁰@DannyParkins says he’s the most confident he’s been in 20 years going into Packers-Bears 👀 pic.twitter.com/sMgBszH7gp
— First Things First (@FTFonFS1) December 17, 2025

Chicago Bears (+1.5) vs Green Bay Packers

Line: Chicago Bears +1.5 with (-120) odds at FanDuel

The Bears under Ben Johnson and Caleb Williams have started to look like a team capable of going toe-to-toe with the big teams. At 10-4, the Bears are currently at the top of the NFC North, and a win against the Packers would provide them with some cushion.

These two teams faced off just a couple of weeks ago in Green Bay, and while the Packers won that game 28-21, the mounting injuries are going to be a concern. The biggest blow the Packers have suffered is the loss of edge rusher Micah Parsons, who was a menace in the previous game with a couple of quarterback hits, six hurries, and seven pressures.

On the flip side, the Bears have an excellent secondary and lead the league in interceptions with 21 from just 15 games. While Jordan Love has taken pretty good care of the ball, 3 of his 6 interceptions have come in the last two games, including one against the Bears in Week 14.

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Week 16 primetime 🤩#NEvsBAL has been moved to NBC at 8:20 PM on December 21. pic.twitter.com/RWiQZrMOrI
— New England Patriots (@Patriots) December 8, 2025

New England Patriots (+2.5) at Baltimore Ravens

Line: Patriots +2.5 with (+100) odds at FanDuel

The New England Patriots come into this Week 16 game still in excellent form. Sure, they might have let a 21-point lead slip against the Bills last week, but they were up against a divisional rival and the reigning MVP.

Prior to last week’s loss, the Patriots held a 10-game win streak, and quarterback Drake Maye has been in the running for the season-ending MVP award for quite some time now. The Ravens rank 25th in the league in passing completion allowed on defense, whereas they rank 27th in passing yards allowed per game.

The Ravens, who started this year 1-5, have managed to climb to .500 at 7-7; however, their most recent wins have come against weaker teams such as the Vikings, Browns, Jets, and even the Bengals this season. Baltimore has, however, struggled against teams above .500, including the Steelers just a couple of weeks ago.

The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

Mandatory Credit: Jay Biggerstaff-Imagn Images

Devavrat Kulkarni

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I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!