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The Seahawks who play the colts are the most favored team in Week 15!
It really is crunch time in the 2025-26 NFL regular season. With just 4 weeks of footballing action left until the playoffs, teams are getting ready for the final push. The top teams from both conferences will be looking to continue their form in order to qualify for the postseason as early as possible.
Week 15 will kick off with the Atlanta Falcons hosting the Tampa Bay Buccaneers in a divisional matchup on Thursday Night Football (TNF) before we get ready for a full slate of 14 games on Sunday, followed by the final game of the week on Monday Night Football (MNF).
Here are some of the picks worth considering ahead of the full slate of Week 15 games as per the odds on FanDuel.
The Rams are the top seed in the NFC with a 10-3 record and have been playing well even against tough competition. Detroit, on the other hand, hasn’t looked like the same team from the past couple of seasons and has struggled against the top teams.
The Chargers and the Chiefs are two AFC West teams trending in opposite directions. While Los Angeles just came off a massive win over the Eagles, the Chiefs lost to the Texans and looked completely out of sorts.
The Broncos have won 10 in a row, while the Packers have been less consistent. Moreover, Green Bay could struggle to score against Denver’s top defense, while the atmosphere at Mile High could add to the difficulty.
Although the Titans have lost several games with double-digit margins, Tennessee has shown improvement over the past few weeks. Apart from their Week 14 win over the Browns, three of the Titans’ previous four games have ended in a single-digit margin loss.
In a massive turn of events, the Indianapolis Colts are suddenly underdogs, and a big one that too against the Seattle Seahawks this week. The Seahawks are favored by 13.5 points over the Colts. Other favorites by a big margin are the Jaguars (-12.5) over the Jets, the 49ers (-12.5) over the Titans, and the Eagles (-11.5) over the Raiders.
The closest game predicted this week is the confrontation between the AFC East teams, the Patriots and the Bills, in which the latter are the favorites by a slim 1.5-point margin.
The moneyline shows a similar trend, but the Seahawks are a colossal -1150 over the Colts. The 49ers come in next at -950, while the Jaguars are at -900, with the Eagles a -770 favorite over the Raiders. As you can imagine, the Bills hold just a -180 line over the Patriots.
Let us now take a look at the betting odds as per FanDuel for all week 15 matchups, along with the predictions.
| Moneyline | Spread | Total Points | |
| Atlanta Falcons | +194 | +4.5 (-110) | O 44.5 (-110) |
| Tampa Bay Buccaneers | -235 | -4.5 (-110) | U 44.5 (-110) |
Prediction: Tampa Bay Buccaneers to win.
| Moneyline | Spread | Total Points | |
| New York Jets | +610 | +12.5 (-110) | O 41.5 (-108) |
| Jacksonville Jaguars | -900 | -12.5 (-110) | U 41.5 (-112) |
Prediction: Jacksonville Jaguars to win.
| Moneyline | Spread | Total Points | |
| Arizona Cardinals | +420 | -5.5 (-110) | O 42.5 (-112) |
| Houston Texans | -560 | +5.5 (-110) | U 42.5 (-108) |
Prediction: Houston Texans to win.
| Moneyline | Spread | Total Points | |
| Buffalo Bills | -118 | -1.5 (-105) | O 49.5 (-110) |
| New England Patriots | +100 | +1.5 (-115) | U 49.5 (-110) |
Prediction: New England Patriots to win.
| Moneyline | Spread | Total Points | |
| Los Angeles Chargers | +180 | +4.5 (-108) | O 42.5 (-102) |
| Kansas City Chiefs | -215 | -4.5 (-112) | U 42.5 (-120) |
Prediction: Los Angeles Chargers to win.
| Moneyline | Spread | Total Points | |
| Las Vegas Raiders | +560 | +11.5 (-115) | O 38.5 (-110) |
| Philadelphia Eagles | -770 | -11.5 (-105) | U 38.5 (-110) |
Prediction: Philadelphia Eagles to win.
| Moneyline | Spread | Total Points | |
| Baltimore Ravens | -146 | -2.5 (-115) | O 51.5 (-110) |
| Cincinnati Bengals | +124 | +2.5 (-105) | U 51.5 (-110) |
Prediction: Cincinnati Bengals to win.
| Moneyline | Spread | Total Points | |
| Washington Commanders | +116 | +2.5 (-112) | O 46.5 (-120) |
| New York Giants | -136 | -2.5 (-108) | U 46.5 (-102) |
Prediction: New York Giants to win.
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| Moneyline | Spread | Total Points | |
| Cleveland Browns | +340 | +7.5 (-108) | O 39.5 (-115) |
| Chicago Bears | -430 | -7.5 (-112) | U 39.5 (-105) |
Prediction: Chicago Bears to win.
| Moneyline | Spread | Total Points | |
| Tennessee Titans | +640 | +12.5 (-108) | O 44.5 (-108) |
| San Francisco 49ers | -950 | -12.5 (-112) | U 44.5 (-112) |
Prediction: San Francisco 49ers to win.
| Moneyline | Spread | Total Points | |
| Detroit Lions | +215 | +5.5 (-105) | O 54.5 (-120) |
| Los Angeles Rams | -260 | -5.5 (-115) | U 54.5 (-102) |
Prediction: Los Angeles Rams to win.
| Moneyline | Spread | Total Points | |
| Carolina Panthers | -158 | -2.5 (-122) | O 40.5 (-105) |
| New Orleans Saints | +134 | +2.5 (+100) | U 40.5 (-115) |
Prediction: Carolina Panthers to win.
| Moneyline | Spread | Total Points | |
| Green Bay Packers | -136 | -2.5 (-110) | O 42.5 (-115) |
| Denver Broncos | +116 | +2.5 (-110) | U 42.5 (-105) |
Prediction: Denver Broncos to win.
| Moneyline | Spread | Total Points | |
| Indianapolis Colts | +730 | +13.5 (-110) | O 42.5 (-110) |
| Seattle Seahawks | -1150 | -13.5 (-110) | U 42.5 (-110) |
Prediction: Seattle Seahawks to win.
| Moneyline | Spread | Total Points | |
| Minnesota Vikings | +225 | +6.5 (-115) | O 47.5 (-115) |
| Dallas Cowboys | -280 | -6.5 (-105) | U 47.5 (-105) |
Prediction: Dallas Cowboys to win.
| Moneyline | Spread | Total Points | |
| Miami Dolphins | +160 | +3.5 (-114) | O 42.5 (-105) |
| Pittsburgh Steelers | -190 | -3.5 (-106) | U 42.5 (-115) |
Prediction: Miami Dolphins to win.
All of the above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!
Mandatory Credit: Imagn Images
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