Mandatory Credit: Denny Medley-Imagn Images

NFL Season Opener Kansas City Chiefs vs Los Angeles Chargers Injury Report Week 1 2025-26 NFL Season

Mandatory Credit: Denny Medley-Imagn Images

the 2025-26 NFL season ignites with a thrilling AFC West clash as the Kansas City Chiefs face the Los Angeles Chargers on Friday, September 5, at Corinthians Arena in Sao Paulo, Brazil, streamed live on YouTube.

The Chiefs, aiming to rebound from a humbling 40-22 Super Bowl LIX loss to the Philadelphia Eagles, just fell short of a historic three-peat despite a dominant 15-2 regular season in 2024. Patrick Mahomes, backed by a revamped offensive line, looks to reassert Kansas City’s dominance in their quest for a 10th straight AFC West title. This international opener, the NFL’s second game in Brazil, carries extra weight as the Chiefs aim to wash away last season’s bitter defeat and set a commanding tone against a familiar rival.

Back on our world tour 🇧🇷 pic.twitter.com/D3tyF5chXv
— Kansas City Chiefs (@Chiefs) September 3, 2025

The Chargers, coming off an 11-6 season and a Wild Card appearance under Jim Harbaugh in 2024, are poised for a breakout season. Justin Herbert’s precision and a bolstered roster, including Najee Harris and breakout star Ladd McConkey, give Los Angeles hope of snapping a seven-game skid against Kansas City. With a strong defense and a ground-heavy scheme, the Chargers could challenge for their first AFC West crown since 2009, making this Week 1 showdown a very critical test.

brazil bound pic.twitter.com/1B8oO8Xocm
— Los Angeles Chargers (@chargers) September 3, 2025

Kansas City Chiefs Injury Report For Game Against Los Angeles Chargers

The international game in Brazil will surely bring in a lot of eyes, especially knowing that the winningest club as of recent memory, the Kansas City Chiefs, will take on Los Angeles Chargers who are on the come up. This fierce AFC West rivalry will bring in a lot of excitement, and both the teams just dropped their first 2025-26 season’s injury report.

Unlike the Chargers, the Chiefs are dealing with a lot of names on the injury list, with many player’s game status unknown at the moment. Unfortunately, it’s been confirmed that wide receiver Jalen Royals is currently dealing with a knee injury and he is ruled out for Friday night’s game against the Chargers.

Defensive Lineman Omarr Norman-Lott is dealing with an ankle injury and was a limited participant on Tuesday and Wednesday. However, WR Hollywood Brown, LB Jack Cochrane, CB Kristian Fulton, T Jawaan Taylor, LB Drue Tranquill, and TE Jared Wiley, were all listed as full participants.

Player	Position	Injury	Status
Jalen Royals	WR	Knee	DNP
Omarr Norman-Lott	DL	Ankle	LP
Hollywood Brown	WR	Ankle	FP
Jack Cochrane	LB	Knee	FP
Kristian Fulton	CB	Knee	FP
Jawaan Taylor	T	Knee	FP
Drue Tranquill	LB	Back	FP
Jared Wiley	TE	Knee	FP

*Note: DNP – Did not practice, FP – Full participant

WR Jalen Royals will not travel with the team. He is ruled OUT for Friday night’s game.

We did not conduct a practice on Wednesday. The below report is an estimation.
— Kansas City Chiefs (@Chiefs) September 3, 2025

Los Angeles Chargers Injury Report For Game vs Kansas City Chiefs

The Chargers are facing an incredibly difficult opponent in Kansas City Chiefs, and are currently on a 7-game losing streak against them and have not won since 2021! With that said, the Chargers are in much better shape than the Chiefs ahead of Week 1 as RB Najee Harris, who was battling an eye injury, was a full participant on Tuesday, but S Elijah Molden, who is dealing with a knee injury, was a limited participant on Tuesday.

Player	Position	Injury	Status
Elijah Molden	S	Knee	LP
Najee Harris	RB	Eye	FP

*Note: DNP – Did not practice, LP – Limited participant, FP – Full participant

tuesday’s #KCvsLAC injury report pic.twitter.com/fkwojmuXee
— Los Angeles Chargers (@chargers) September 2, 2025

Except for the Chiefs’ Jalen Royals, the game time status for other players on the injury list for both the Chiefs and the Chargers, is currently now known at the moment. And we will see if they are ready to play for international game held in Sao Paulo, Brazil, as the opening day for both the teams approaches. With most players having no significant injuries, the stage is set for a great showdown between the Chiefs and the Chargers.

Kansas City Chiefs

Los Angeles Chargers

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NFL 2025-26 Regular Season

Eric Divakaran

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I cover the National Football League and things cannot get better than that. I always dreamed to play football or basketball professionally since I’m built like a Running Back. But now that I can’t, since I’m technically in the “Unc” age, I thought why not pick a career in sports industry? So here I am, doing what I love, and hoping that the Commanders win the Super Bowl. I give love to players when it’s due, but can be critical about their performances at the same time. Enough about me, now let my articles do all the talking.