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Milwaukee Bucks vs Detroit Pistons Predictions, Betting Odds and Best Bets for Saturday, November 22

The Milwaukee Bucks will lock horns with the Detroit Pistons in an NBA 2025-26 regular season clash on November 22 at home. They are heading off a three game losing streak and are seemingly desperate to turn around the outcomes of their previous games. On the other hand, we have the Detroit Pistons, who are coming on the back of an eleven-game winning streak. The Pistons are leading the Eastern Conference with a staggering 13-2 record, while the Bucks are at tenth spot with an 8-8 record.

Game Details

Date: Saturday, November 22, 2025
Time: 8 pm ET
Location: Fiserv Forum in Milwaukee, Wisconsin
TV: FDSDET, FDSWI, and NBA TV
Live Stream: Fubo, NBA League Pass

Recommended Bets and Odds

Recommended Bet	FanDuel	BetMGM
Cade Cunningnam O 28.5 points	-118	–

Analysis and Rationale

Cade Cunningham has been leading the Pistons at an average of 27.3 points, 5.4 rebounds, and 9.9 assists per game this season. He has been shooting 43.6% from the field and 27.5% from the three-point range. Having missed three back-to-back games with left hip contusion, Cunningham returned to the court with a 25 point performance. He shot 43.5% from the field and 14.3% from the three-point range against the Hawks. In fact, in the last five games that he has played, Cunningham scored over 30 points on three occasions, including a 46-point show.

Considering how the Bucks have been struggling lately both offensively and defensively, we can expect Cunningham to score over 29 points.

Milwaukee Bucks vs Detroit Pistons Predictions

The Milwaukee Bucks were one of the top performers last season. Though their playoff trip was cut short in the opening round, they finished fifth in the league. Giannis Antetokounmpo carried the burden of the team throughout the season, but an overall lack of effort kicked them out early from the championship race. In the ongoing season, they kicked off the season with two back-to-back wins but soon lost momentum.

They have been struggling with consistency and haven’t been able to win three games in a row. While the Bucks were hoping to get back into form, Giannis Antetokounmpo’s injury woes made it worse for them. The Greek Freak sustained a low-grade left groin strain and was sidelined for one-two weeks. Considering he is the only player in the league averaging 30 points and 10 rebounds, Antetokounmpo’s injury came as a huge blow for Milwaukee.

They have an offensive rating of 114.8 and a defensive rating of 116.2, which place them towards the bottom half of the standings.

On the other hand, we have the Detroit Pistons, who finished the previous season fifth in the league. In the ongoing season, they have been in great form and are currently on an eleven-game winning record. Overall, the Pistons have won 13 games with two losses in 15 games. In terms of stats, the Pistons have the 12th best offensive rating of 116.3 and the second best defensive rating of 109.6.

Considering that the Bucks will be without their superstar puts them in a tough spot, despite the fact that they have homecourt advantage. On the other hand, the Pistons are in great form and highly likely to extend their winning streak to 12 games.

Predictions: Detroit Pistons to win.

Milwaukee Bucks vs Detroit Pistons Betting Odds and Spread

	Spread	Moneyline	Total
Detroit Pistons	-9 (-106)	-375	O 224.5 (-106)
Milwaukee Bucks	+9 (-114)	+300	U 224.5 (-114)

Milwaukee Bucks vs Detroit Pistons Over/Under Odds and Best Bets

Milwaukee Bucks Over/Under Odds

Recommended Bets	Over	Under
Ryan Rollins 21.5 points	-110	-120
Myles Turner 14.5 points	-112	-118
Gary Trent Jr. O 2.5 made threes	-112	-118

Milwaukee Bucks Best Bets

Bobby Portis to score over 15 points: +118
Myles Turner to record 8+ rebounds: +114
Bobby Portis to record a double double: +175

Detroit Pistons Over/Under Odds

Recommended Bets	Over	Under
Jalen Duren 17.5 points	-130	-102
Tobias Harris 10.5 points	-112	-118
Jalen Duren 12.5 rebounds	-118	-112

Detroit Pistons Best Bets

Duncan Robinson to score 15+ points: +215
Cade Cunningham to hit 3+ made threes: +148
Jalen Duren to record a double-double: -320

The odds given above have been sourced from FanDuel. Use FanDuel to ace your betting game across all sports.

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FAQs

What is the over/under for total points for the Bucks vs Pistons game?

The over/under for total points in the game between the Bucks and Pistons is set at 224.5.

What is the point spread for the Bucks vs Pistons game?

The Pistons have a significant 9.5 point edge over the Pistons.

What is the moneyline for the Bucks vs Pistons game on Saturday?

The Pistons are favorites to win with moneyline odds of -375, while the Bucks are underdogs at +300.

Garima Ranawat

Garima is a sports writer with around two years of experience in Indian sports and a newfound interest in the NBA. Inspired by the leadership of cricketing legend MS Dhoni, she wishes to bring in newer perspectives to the NBA fanatics with her writing.