Miami Dolphins vs Buffalo Bills Preview, Betting Odds, and Predictions – NFL 2025-26 Season Week 3

Miami Dolphins vs Buffalo Bills Preview, Betting Odds, and Predictions for the 2025-26 NFL Season Week 3

The Miami Dolphins take a trip up north as they take on their AFC East divisional opponents, the Buffalo Bills. Both teams head into this matchup in contrasting fashion. Buffalo has started the season strong with 2 wins, while Miami has taken the opposite route, losing both of theirs.

We will find out what this game has in store for us on Thursday Night Football (TNF) as both teams get ready to kick off week 3 action.

Recommended bets and updated odds

Recommended Bets	FanDuel	BetMGM
James Cook any time TD scorer	-175	-180
Josh Allen 2+ Passing Touchdowns	-158	-148
Bills to win	-850	-715

Analysis and Rationale

Taking the Bills’ running back James Cook as an anytime touchdown scorer seems like a good idea. If we look at his past 18 games, Cook has 19 rushing touchdowns. In 16 regular season games last year, he led the league with 16 touchdowns on the ground, and so far this season, he already has 3 from 2 games.

Josh Allen’s 2+ passing touchdowns also seem very much achievable given the form he is currently in. Moreover, the biggest factor to consider here is how well Allen has played against the Dolphins in his career. In 14 games, he has already thrown 37 touchdowns.

Taking the Bills to win in this game seems like a no-brainer. Both teams are at opposite ends of the spectrum in terms of their quality and execution. Furthermore, it is a home game for Buffalo, and that too on a short week. And to make matters worse for Miami, the Bills are 12-2 against them with Allen under center.

#Dolphins QB Tua Tagovailoa on Josh Allen:

"That dude can do literally anything he wants. Definitely different skill set for me. I can’t do half of what he does."

(via @MiamiDolphins, h/t @FinsXtra)pic.twitter.com/XpqZtrrkjf
— Ari Meirov (@MySportsUpdate) September 16, 2025

Miami Dolphins vs Buffalo Bills Preview

As mentioned previously, Buffalo has had a strong start to its season with a come from behind win over the Baltimore Ravens that saw Josh Allen at his best in the fourth quarter.

And if it was all about him in the week 1 victory, it was all about James Cook from the backfield in week 2 against the Jets. Cook ran for 132 yards and 2 touchdowns from 21 carries as the Bills demolished New York.

The Miami Dolphins have become a sad story. Even the likes of Tyreek Hill and Jaylen Waddle are not enough to lift the Dolphins. They got blown out in the season opener by the Indianapolis Colts of all teams and then lost a back-and-forth contest against the Patriots in week 2.

Miami Dolphins Best Bets – Over/Under and Player Bets

Below are some of the best player bets for the Miami Dolphins as sourced from FanDuel.

Miami Dolphins Over/Under Bets

Over/ Under Bets	Over	Under
Tua Tagovailoa passing yards	238.5 (-114)	238.5 (-114)
Jaylen Waddle receiving yards	50.5 (-114)	50.5 (-114)
De’Von Achane rushing yards	55.5 (-114)	55.5 (-114)

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Miami Dolphins Best Player Bets

Below are some of the best player bets for the Miami Dolphins as sourced from FanDuel.

Most passing yards – Tua Tagovailoa: -122
Tyreek Hill most receiving yards: +175
De’Von Achane 40+ rushing yards: –320

Buffalo Bills Best Bets – Over/Under and Player Bets

Here is a look at the over/under and player bets for the Buffalo Bills as per FanDuel.

Buffalo Bills Over/Under Bets

Over/ Under Bets	Over	Under
Josh Allen passing yards	233.5 (-114)	233.5 (-114)
Khalil Shakir receiving yards	40.5 (-114)	40.5 (-114)
James Cook rushing yards	67.5 (-114)	67.5 (-114)

Buffalo Bills Best Player Bets

Below are some of the best player bets for the Buffalo Bills as sourced from FanDuel.

Josh Allen or James Cook – either player anytime touchdown scorer: -750
Keon Coleman most receiving yards: +550
Josh Allen 25+ rushing yards: -152

This is why the Bills signed Joey Bosa

When a healthy a legit game wrecker#BillsMafia | #GoBills
pic.twitter.com/oXaSK0Q8bu
— Peter DiBiasi (@DibiasiPeter) September 15, 2025

Week 3 Dolphins vs Bills Predictions for NFL 2025-26 Season Opener

The way both teams are playing, Buffalo has the upper hand and is rightly so are massive favorite to go 3-0, while the Dolphins fall to 0-3. As the saying goes, that games are not played on paper holds true, but even then, it would take a miracle for Miami to pull off an upset on Thursday.

Josh Allen and company are simply too strong for the Dolphins’ defense, and even if Miami puts up points on the board, stopping the Bills from scoring will be a huge ask.

Our Prediction: Bills to win and cover the spread.

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Dolphins vs Bills Betting Odds and Spread

The moneyline and spread show the Buffalo Bills are heavy favorites in this matchup against the Miami Dolphins, as sourced from FanDuel.

	Moneyline	Spread	Total Points
Miami Dolphins	+590	+11.5 (-106)	O 49.5 (-118)
Buffalo Bills	-850	-11.5 (-114)	U 49.5 (-104)

The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

FAQs

What is the over/under for total points for the Dolphins vs Bills game?

The over/under for total points in the Dolphins vs Bills game is set at 49.5.

What is the point spread for the Dolphins vs Bills game on Sunday?

The Bills come into the game as massive 11.5-point favorites over the Dolphins.

What is the moneyline for the Dolphins vs Bills game in week 2?

The Bills are the favorites with a moneyline of -850, while the Dolphins are the underdogs at +590.

Mandatory Credit: Mark Konezny-Imagn Images

Devavrat Kulkarni

nfl

I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!