Los Angeles Chargers vs Denver Broncos Preview, Betting Odds, and Predictions – NFL 2025-26 Season Week 3

Chargers take on the Broncos in an all-AFC West battle!

Los Angeles Chargers vs Denver Broncos Preview, Betting Odds, and Predictions for the 2025-26 NFL Season Week 3

The Los Angeles Chargers will be playing their third consecutive game against their AFC West divisional rivals, this time going up against the Denver Broncos. At 2-0, the Chargers are a much-improved unit in their second year under coach Jim Harbaugh.

As for the Broncos, Sean Payton and Bo Nix started clicking towards the end of last season. Looking to take things forward, Nix struggled in week 1 against the Titans, and Denver’s loss against the Colts in week 2 is raising a little concern.

Recommended bets and updated odds

Recommended Bets	FanDuel	BetMGM
Chargers to cover -2.5 spread	-120	-114
J.K. Dobbins anytime TD scorer	+140	+148
Justin Herbert 200+ passing yards	-420	-455

Analysis and Rationale

The game between the AFC West opponents, the Los Angeles Chargers and the Denver Broncos, is expected to be a close one. That is also why the Chargers are slight favorites with a -2.5 point spread. We think L.A. will cover the spread as they have played well in the previous two weeks and have defeated the Chiefs by 6 points and the Raiders by 11.

J.K. Dobbins has been a positive in the Broncos’ run game. In the previous two games, he has run for 63 and 76 rushing yards, respectively. Additionally, Dobbins has found the endzone in both matches, making us believe that he could do the same against the Chargers.

Justin Herbert has started the season strong, and despite losing Rashawn Slater, the Chargers’ O-line is providing him time in the pocket. As a result, Herbert has over 550 passing yards in 2 games. However, the Broncos’ pass defense is better than their run defense, so we expect Herbert to have a 200+ yard passing game.

It's Chargers Week. pic.twitter.com/TL8RZi1xgn
— Denver Broncos (@Broncos) September 17, 2025

Los Angeles Chargers vs Denver Broncos Preview

Los Angeles is heading into this week 3 game with superb wins against the Kansas City Chiefs and the Las Vegas Raiders. The offensive line is providing quarterback Justin Herbert plenty of time to pick his receivers, while the defense has done a fine job of keeping things quiet thus far.

Meanwhile, Denver came through in week 1 against the Titans, but the game was a scrappy one. They were on the verge of winning in week 2, but a penalty during the failed field goal attempt by the Colts made things easier for Indy, sending the Broncos to 1-1.

Los Angeles Chargers Best Bets – Over/Under and Player Bets

Below are some of the best player bets for the Los Angeles Chargers, as sourced from FanDuel.

Los Angeles Chargers Over/Under Bets

Over/ Under Bets	Over	Under
Justin Herbert pass attempts	33.5 (-102)	33.5 (-128)
Courtland Sutton receiving yards	53.5 (-114)	53.5 (-114)
Omarion Hampton rushing yards	40.5 (-114)	40.5 (-114)

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Los Angeles Chargers Best Player Bets

Below are some of the best player bets for the Los Angeles Chargers, as sourced from FanDuel.

Ladd McConkey any time TD scorer: +145
Omarion Hampton 40+ rushing yards: -125
Keenan Allen most receiving yards: +350

Denver Broncos Best Bets – Over/Under and Player Bets

Here is a look at the over/under and player bets for the Denver Broncos, as per FanDuel.

Denver Broncos Over/Under Bets

Over/ Under Bets	Over	Under
Bo Nix pass attempts	33.5 (-108)	33.5 (-120)
Ladd McConkey total receptions	4.5 (-182)	4.5 (+136)
J.K. Dobbins rushing yards	51.5 (-114)	51.5 (-114)

Denver Broncos Best Player Bets

Below are some of the best player bets for the Denver Broncos, as sourced from FanDuel.

Bo Nix to throw an interception: -144
Courtland Sutton 4+ Receptions: -300
J.K. Dobbins most rushing yards: +110

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Week 3 Chargers vs Broncos Predictions for NFL 2025-26

Divisional games are always difficult to predict, and when there are two teams similar in quality, it makes it all the more difficult. However, the Broncos are 1-1, and even though they won against Tennessee, it wasn’t their best outing.

The Chargers seem to have the better roster at the moment, and both their wins have been inspiring. If the Chargers’ O-line can contain the Broncos’ first line of defense, then Herbert will be able to unlock the passing game.

Our Prediction: Chargers win and cover the spread

🚨🚨HISTORY🚨🚨

Los Angeles #Chargers kicker Cameron Dicker is now the MOST ACCURATE KICKER IN #NFL HISTORY.

Dicker now has has 94% field goal percentage the greatest ever on minimum of 100 field goals attempted.

Cam is 94 of 100.

DICKER THE KICKER. NFL LEGEND. pic.twitter.com/ZKJjll2rbZ
— MLFootball (@_MLFootball) September 16, 2025

Chargers vs Broncos Betting Odds and Spread

The moneyline and spread show the Los Angeles Chargers are slight favorites in this matchup against the Denver Broncos, as sourced from FanDuel.

	Moneyline	Spread	Total Points
Los Angeles Chargers	-154	-2.5 (-120)	O 45.5 (-115)
Denver Broncos	+130	+2.5 (-102)	U 45.5 (-105)

The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

FAQs

What is the over/under for total points for the Chargers vs Broncos game?

The over/under for total points in the Chargers vs Broncos game is set at 45.5.

What is the point spread for the Chargers vs Broncos game on Sunday?

The Chargers come into the game as slight 2.5-point favorites over the Broncos.

What is the moneyline for the Chargers vs Broncos game in week 2?

The Chargers are the favorites with a moneyline of -154, while the Broncos are the underdogs at +130.

Mandatory Credit: Kiyoshi Mio-Imagn Images

Devavrat Kulkarni

nfl

I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!