Aug 26, 2025; Flushing, NY, USA; Lorenzo Musetti (ITA) hits the ball to Giovanni Mpetshi Perricard (FRA)(not pictured) on day three of the 2025 U.S. Open tennis tournament at the USTA Billie Jean King National Tennis Center at Billie Jean King National Tennis Center. Mandatory Credit: Amber Searls-Imagn Images

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Lorenzo Musetti vs. Flavio Cobolli Preview, Prediction and Betting Odds for US Open 2025 Round-3

All-Italian contest for a spot in the Round of 16.

It will be an all-Italian face-off in the 2025 US Open Round-3, when Lorenzo Musetti will battle Flavio Cobolli on Saturday. Musetti has not endured the best of seasons, but looks primed for a deep run in New York. At the same time, Cobolli is coming off a series of upsets, and has turned into the player to watch out for in this event. So who will prevail in this electric contest? Let’s find out, using the accurate betting odds provided by BetMGM.

Lorenzo Musetti vs. Flavio Cobolli Match Preview

Coming into the tournament, several predictions had an early exit for Lorenzo Musetti on the cards. After all, the Italian was coming off a disappointing Wimbledon run, and his North American swing hadn’t been anything noteworthy. As a result, expectations were relatively low from the World No. 10. However, Musetti seems to have turned a corner in the US Open – he has notched impressive wins against Mpetshi Perricard and Goffin. Having hit a purple patch during the clay court season, Musetti will be keen on having a successful end to his campaign.

On other hand, Flavio Cobolli has been the breakout Italian of this season. After a deep run at the Wimbledon Championships, Cobolli is showing signs of recreating it in New York. More importantly, the hard-courts in New York could turn into a great equalizer for Cobolli, as Musetti’s record here is not the best by any means. As the 23-year-old looks to dethrone his predecessor as the Italian No. 1, the US Open Round of 32 is set for some fireworks.

Lorenzo Musetti vs. Flavio Cobolli Head to Head

This will be the first time Lorenzo Musetti and Flavio Cobolli will face each other on the professional circuit.

Lorenzo Musetti vs. Flavio Cobolli Career Comparison

Lorenzo Musetti	Category	Flavio Cobolli
10	Current Rank	26
26/12	YTD W/L	25/19
0	YTD Titles	2
158/123	Career W/L	66/57
2	Career Titles	2

Lorenzo Musetti vs. Flavio Cobolli US Open 2025 Prediction

Before Lorenzo Musetti’s rekindled run of momentum, Flavio Cobolli would have been an easy favorite for this match. However, the more experienced and accomplished Italian is playing with freedom. The serve and backhand have found the required rhythm to keep him alive in rallies. On the other hand, Cobolli likes to take matches deep and outhit opponents in baseline exchanges.

Prediction: Lorenzo Musetti in five sets.

Lorenzo Musetti is eyeing the second round 👁️ #usopen pic.twitter.com/MvVqrOUT4U
— Tennis Channel (@TennisChannel) August 26, 2025

Lorenzo Musetti vs. Flavio Cobolli US Open 2025 Betting Odds

Musetti remains ahead of Cobolli based on the accurate odds from BetMGM.

Lorenzo Musetti win – 7/20
Flavio Cobolli win – 21/10

Total Sets 3 – 6/5
Total Sets 4 – 33/20
Total Sets 5 – 13/5
Total Games >37.5 – 83/100
Total Games <37.5 – 17/20
Set 1 Winner Musetti – 1/2
Set 1 Winner Cobolli – 29/20

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

Mandatory Credit: Amber Searls-Imagn Images

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Sanskar Dubey

A passionate sports fan since childhood, it was always my dream to cover the peak of human potential. Baseball, Tennis, and Football (or Soccer) have been closest to my heart. From Rafael Nadal’s never-say-die attitude to Roger Federer’s beautiful backhand, I’ve seen it all. Prior to the Playoffs, I’ve worked in EssentiallySports and Pro Football and Sports Network.