Aug 26, 2025; Flushing, NY, USA; Lorenzo Musetti (ITA) hits the ball to Giovanni Mpetshi Perricard (FRA)(not pictured) on day three of the 2025 U.S. Open tennis tournament at the USTA Billie Jean King National Tennis Center at Billie Jean King National Tennis Center.

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Lorenzo Musetti vs. David Goffin Head-to-Head, Prediction and Betting Odds for US Open 2025 Round-2

Winner to face Cobolli or Brooksby in Round-3.

Having won just his third non-clay court Grand Slam match of the year on Tuesday, World No. 10 Lorenzo Musetti returns to action against David Goffin of Belgium. This US Open 2025 Round of 64 fixture will determine who advances to face either Flavio Cobolli or Jenson Brooksby in the next stage of the tournament. Let’s take a look at everything you need to know about this heated battle before placing your bets (with the help of BetMGM).

Lorenzo Musetti vs David Goffin Match Preview

One of the clay court virtuosos of the men’s game, Lorenzo Musetti milked the mid-season points to rise to No. 6 in the world at one stage. Reaching the final in Monte Carlo and semifinals at Madrid, Rome and Roland Garros, the 23-year-old proved that his Paris Olympics bronze medalist was no beginner’s luck. Although he is yet to strike championship success in 2025, Musetti’s flashy game means that glory could be just around the corner. The Italian powerhouse has served 66 aces on this surface this year, and won 80% of his hard court service games during this period.

Forza Lore! 💪

Musetti dispatches Mpetshi Perricard in 4. pic.twitter.com/pEaJHVxkKm
— US Open Tennis (@usopen) August 26, 2025

Meanwhile, David Goffin was a constant name in the Top-10 during his prime. A former ATP World Tour Finals runner-up in his own right, Goffin has six career singles titles to his name. In spite of his collapse to No. 80 in the world, the 34-year-old continues to put up the occasional run of quality performances. By reaching the quarterfinals in Munich and Round of 16 in Gstaad, Goffin improved his 2025 win-loss record to 9-16. He defeated Quentin Halys 6-7(2) 6-4 6-3 7-5 in Round-1.

Lorenzo Musetti vs David Goffin Head to Head Record

Musetti leads the head-to-head against Goffin by 2-1 at the moment. While the Italian won their first two battles at the Grand Slam level, Goffin returned the favour at the 2024 Shanghai Rolex Masters.

Event	Round	Winner	Score
2024 Shanghai	Round of 64	David Goffin	1-6 7-6(6) 6-2
2022 US Open	Round of 128	Lorenzo Musetti	3-6 7-5 6-4 3-6 7-6(9)
2021 Roland Garros	Round of 128	Lorenzo Musetti	6-0 7-5 7-6(3)

Lorenzo Musetti vs David Goffin Career Comparison

Lorenzo Musetti	Category	David Goffin
10	Current Ranking	80
159-123	Career W-L Record	355-269
27-12	YTD W-L Record	9-16
2	Career Titles	6
0	YTD Titles	0
0	Grand Slams	0

Lorenzo Musetti vs David Goffin US Open 2025 Prediction

Goffin has reached the Fourth Round in New York on four separate occasions. While he is a hard court maestro, the 34-year-old lacks the endurance and venom to stay within touching distance of the youngsters. Meanwhile, Musetti’s deep stance will make his groundstrokes flatter – drawing some potential short neutral balls from the Goffin racquet. While there is potential for the Belgian to make inroads in backhand to backhand exchanges, it is unlikely that there will be an upset.

Prediction: Lorenzo Musetti in four sets.

An INCREDIBLE match.

🇮🇹 @lorenzomusetti_ outlasts David Goffin in a final set tiebreak. pic.twitter.com/WbZLvrHbp4
— US Open Tennis (@usopen) August 31, 2022

Lorenzo Musetti vs David Goffin US Open 2025 Betting Odds

The betting odds for this US Open 2025 Round-2 encounter are heavily stacked in Lorenzo Musetti’s favour. The Italian comes in with an 86% chance of progressing to the next round, according to the money line. Our expert betting market also suggests something along similar lines – take a look (as per BetMGM):

Lorenzo Musetti Win: 2/13
David Goffin Win: 22/5

Total Games >34.5: 22/25
Total Sets >3.5: 41/50
Musetti to Win 3-0: 11/10
Goffin to Win At Least 1 Set (Yes): 4/6
Set-1 & Set-2 to Musetti: 8/25
Total Games in Set-2 >9.5: Evens

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

(Image Credits: Amber Searls, Imagn Images)

Betting

David Goffin

Flavio Cobolli

Lorenzo Musetti

Tennis

US Open 2025

Sankalp Harikrishnan

A passionate sports fan through and through, I am currently pursuing my MA in Global Sports Journalism. I specialise in tennis and football writing at The Playoffs News, and I have prior experience working at EssentiallySports and Sportskeeda. Born and raised in Bengaluru, India, sport was my safe space right from my childhood. After trying my hand at multiple sports and representing my educational institutions in cricket, badminton and table tennis, I found sports media to be my calling.