Liverpool vs Atletico Madrid Preview, Betting Odds and Predictions – 17/09/2025

Liverpool host Atletico Madrid at Anfield in one of the standout fixtures of Champions League matchweek one. The Premier League champions have started their domestic campaign in flawless fashion, while Diego Simeone’s men only secured their first La Liga win of the season at the weekend.

Liverpool’s 1-0 win at Burnley on Sunday made them the first team in Premier League history to win each of their opening four matches with goals scored in the final 10 minutes. It may not always have been pretty, but the Reds’ knack for late winners has them sitting top of the Premier League table with a perfect record.

This season's winning goals 😉🍿 pic.twitter.com/yFE2ARdEwM
— Liverpool FC (@LFC) September 15, 2025

Liverpool vs Atletico Madrid Best Bets

Bets	Moneyline	Moneyline
Full Time Result	Liverpool: -175, Atletico Madrid: +400	Draw: +320
Draw No Bet	Liverpool: -450	Atletico Madrid: +280
Total Goals	Over 3.5: +145	Under 3.5: -200
Liverpool to Win and Both Teams to Score	Yes: +195	No: +185
Atletico Madrid to Win and Both Teams to Score	Yes: +700	No: +800

(Odds via BetMGM)

Liverpool vs Atletico Madrid Preview

Slot will now turn his focus to Europe, where Liverpool will aim to erase memories of last season’s painful last-16 exit to eventual winners Paris Saint-Germain. On the other hand, Atletico Madrid, meanwhile, took just two points from their first three outings against Espanyol, Elche and Alaves. The international break proved timely for Atleti, who bounced back by defeating Villarreal 2-0 on home soil.

Historically, this is a matchup with plenty of intrigue. Atletico frustrated Liverpool across their first six competitive encounters, losing only once. But the Reds have since turned the tide with back-to-back wins over Simeone’s men in the 2021-22 group stage. With Liverpool in red-hot form and Atletico searching for consistency, Wednesday’s showdown at Anfield promises to be a compelling clash of styles.

Also read: Atletico Madrid Suffer Double Injury Scare Ahead of Champions League Clash With Liverpool

Liverpool vs Atletico Madrid Over/Under Predictions

Liverpool vs Atletico Madrid Under 3.5 Goals @ -200 as per BetMGM

A low-scoring battle looks likely when Liverpool and Atletico Madrid lock horns. The Reds have been clinical but not free-flowing in recent outings, with each of their last two matches ending in 1-0 wins against Burnley and Arsenal.

Atletico, meanwhile, are known for their compact defensive style, and their recent results only reinforce that reputation. They played back-to-back 1-1 draws against Alaves and Elche before finally earning a clean sheet in a 2-0 win over Villarreal. Based on recent form, backing Under 3.5 Goals feels the safest play here.

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Liverpool vs Atletico Madrid Player Picks

Hugo Ekitike to score anytime @ +125 as per BetMGM:

Ekitike has started life at Liverpool brightly in the Premer league. Coming off a prolific season with Eintracht Frankfurt, where he scored 22 times, the forward looks sharp and confident in front of goal. His rich form makes him a strong pick to get on the scoresheet again at Anfield.

Also read: Alexis Max Allister Injury Update: What Did Liverpool Boss Arne Slot Say?

Liverpool vs Atletico Madrid Final Scoreline Prediction

Back-to-back clean sheets against Arsenal and Burnley highlight how Arne Slot’s men have rediscovered their discipline at the back. Atletico Madrid, on the other hand, arrive at Anfield with several key injury concerns and limited firepower.

Diego Simeone’s side have found goals hard to come by in La Liga and may struggle to break down the Reds. Given Liverpool’s current form and Atletico’s lack of cutting edge, the hosts should have enough quality to grind out another win.

Final Prediction: Liverpool 2-0 Atletico Madrid

Bettors can explore a variety of betting options on BetMGM, including full-time results, over/under goals, and player props for this Champions League clash.

Abhinav Goel

soccer

I am a soccer writer at The PlayOffs, covering everything from match analysis to transfer buzz and tactical deep dives. Ever since I was a kid, soccer has been more than just a sport to me—it’s been an obsession. Playing and watching the game from a young age fueled my passion, eventually leading me into the world of sports media and betting. Now, I get to analyze the sport I love and bring the latest updates to fans worldwide.