Credits: IMAGO / Focus Images

La Liga Best Bet of the Day – Our Top La Liga Picks for March 22, 2026

Credits: IMAGO / Focus Images

The La Liga schedule on Sunday, March 22, 2026 delivers a compelling number of fixtures that could influence both the title race and the European qualification battle. League leaders FC Barcelona will host Rayo Vallecano with the chance to extend their advantage at the summit.

Meanwhile, the Madrid derby between Real Madrid and Atletico Madrid will bring two contrasting tactical styles together in a high-stakes encounter. Elsewhere, Athletic Bilbao will welcome Real Betis to San Mames in a matchup between sides chasing European places.

📅 ¡Hoy comienza la Jornada 29 de #LALIGAEASPORTS! #LALIGABroadcasters
— LALIGA (@LaLiga) March 20, 2026

For more analysis across England and Europe, visit our main soccer predictions and La Liga betting tips hub, but for now, scroll on for today’s best bets.

Our La Liga Best Picks of March 22

Match	Market & Pick	Odds & Book
Barcelona vs Rayo Vallecano	Barcelona to Win	-235 via Fanduel
Real Madrid vs Atletico Madrid	BTTS: Yes	-185 via BetMGM
Athletic Bilbao vs Real Betis	Total Goals Over 1.5	-325 via FanDuel

Odds from FanDuel and BetMGM, accurate as of Friday morning ET. La Liga lines can move quickly on matchday, so always check the latest prices before betting.

Best Bet #1 – Barcelona vs Rayo Vallecano: Barcelona to Win

Market	Pick	Odds & Book
Match Result	Barcelona to Win	-235 via Fanduel

Sunday’s clash at Camp Nou will see Barcelona attempting to reinforce their lead in La Liga against a resilient Rayo Vallecano side. Under manager Hansi Flick, Barcelona have developed one of the most productive attacking systems in Spain this season. The Catalan club have scored 77 goals in 28 league matches.

They’re averaging nearly 2.8 goals per game while generating approximately 2.1 xG per match over their last ten fixtures. Barcelona’s form has also been emphatic across competitions. They are coming into the game on a strong run that includes a 7-2 win over Newcastle United in the UEFA Champions League.

Players, like Robert Lewandowski, Raphinha, and Lamine Yamal have combined to produce one of the league’s highest shot totals. Rayo Vallecano, while competitive, have struggled to maintain defensive solidity against elite opponents.

Their last ten matches across competitions show an xGA figure hovering around 1.4 per match. They have also conceded multiple goals in several meetings with top-six teams this season. Barcelona also hold a strong historical edge. They’ve won 30 of the last 48 encounters between the clubs.

Best Bet #2 – Real Madrid vs Atletico Madrid: BTTS: Yes

Market	Pick	Odds & Book
Both Teams to Score	Yes	-185 at BetMGM

The Madrid derby between Real Madrid and Atletico Madrid will be held at Santiago Bernabeu Stadium. Real Madrid remain one of Europe’s most efficient attacking teams. They’re generating more than 2.2 xG per match across their last ten games. Much of that production revolves around the movement and finishing ability of Kylian Mbappe and Vinícius Jr.

Mbappe’s pace behind defensive lines forces opposing backlines to retreat. Vinícius thrives in isolation situations on the left flank. Together they account for a significant share of Real Madrid’s progressive carries and shot creation. Diego Simeone’s Atletico Madrid maintain their trademark defensive structure.

But they have become more adventurous in attack this season. Players such as Antoine Griezmann and Alvaro Morata provide consistent goal threats. Across their last ten fixtures, Atletico are averaging roughly 1.6 xG per match while conceding just over 1.1 xGA.

Head-to-head meetings between these rivals frequently produce goals at both ends. Four of their last six league encounters have seen each side score. Derby intensity also tends to generate open moments late in matches when either team pushes for a decisive result.

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Best Bet #3 – Athletic Bilbao vs Real Betis: Total Goals Over 1.5

Market	Pick	Odds & Book
Total Goals	Over 1.5	-325 at FanDuel

The meeting between Athletic Bilbao and Real Betis will be held at San Mames Stadium. Over their last ten league matches, Athletic Bilbao have averaged close to 1.8 xG per game. A significant portion of Bilbao’s attacking threat comes from Nico Williams. His pace and dribbling ability consistently destabilize opposing defenses.

His ability to beat defenders in wide areas creates crossing opportunities and cutbacks that lead to high-value scoring chances. Manuel Pellegrini’s Real Betis with players, like Isco and Nabil Fekir excel at progressive passing and ball retention. It helps Betis generate scoring opportunities through sustained buildup phases.

However, their defensive record away from home has been inconsistent. Betis have conceded in seven of their last ten away games. They’re boasting an average xGA above 1.3 per match. Six of last eight meetings between these two sides in La Liga have featured at least two total goals. Hence, the Over 1.5 market provides a relatively safe entry point.

La Liga Best Bets for March 22, 2026

Best Bet #1: Barcelona vs Rayo Vallecano – Barcelona to Win (-235 at FanDuel)
Best Bet #2: Real Madrid vs Atletico Madrid – BTTS: Yes (-185 at BetMGM)
Best Bet #3: Athletic Bilbao vs Real Betis – Total Goals Over 1.5 (-325 at FanDuel)

Athletic Bilbao

Atletico Madrid

Barcelona

La Liga

Rayo Vallecano

Real Betis

Real Madrid

Moumita Dutta

soccer

Football writer at The Playoffs. I’ve been obsessed with the beautiful game since I was a kid.. Eventually, I realized I could combine my passion for writing with my love for football, and I’ve never looked back. My favorite part of the job is everything—when you’re doing what you love, even a late-night deadline feels like extra time in a thrilling cup final. Lastly, Lionel Messi is the GOAT.