Mandatory Credit: Robert Deutsch-Imagn Images

Jessica Pegula vs. Ann Li Head-to-Head, Preview, Prediction, and Betting Odds for US Open 2025 Round of 16

Last year's finalist Pegula faces Li, who eyes her first Grand Slam quarterfinal.

Mandatory Credit: Robert Deutsch-Imagn Images

Fourth seed Jessica Pegula will take on unseeded Ann Li in the fourth round of the 2025 US Open. Pegula has looked sharp in New York, cruising past Mayar Sherif, Anna Blinkova, and Victoria Azarenka without dropping a set. Li, meanwhile, battled through a three-set opener against Rebecca Sramkova but has since rolled past 16th seed Belinda Bencic and qualifier Priscilla Hon to reach the biggest stage of her career.

Jessica Pegula reaches her 10th career Grand Slam second week! pic.twitter.com/Gr5x9T1rZ1
— US Open Tennis (@usopen) August 29, 2025

For Pegula, this tournament is a welcome return to form. Since capturing the Bad Homburg title with a thrilling victory over Iga Swiatek, the American had failed to advance beyond the second round at any event. Her season has still included highs like deep runs in Adelaide and Miami and titles in Austin and Charleston, where she beat McCartney Kessler and Sofia Kenin. But Grand Slam disappointments have weighed heavily, including an early exit to Lois Boisson at Roland Garros. Statistically, Pegula has remained steady with 135 aces, 67.6% first-serve points won, and a 44.1% break-point conversion rate across 53 matches.

Milestone reached ✅

Ann Li defeats Priscilla Hon and reaches her first Grand Slam Singles Round 4. pic.twitter.com/fKdlDo0Qyw
— USTA (@usta) August 29, 2025

Li, on the other hand, is experiencing a breakthrough moment. Without a title since Tenerife 2021, her current fourth-round run marks her career-best Grand Slam reach. She has advanced to finals in Singapore and Tennis in the Land, alongside quarterfinals in Morocco and Prague, but consistency has often eluded her. Still, her numbers, with 153 aces, 65.3% first-serve points won, and 44.3% break conversion, are clear indications of her being a threat, if in form.

Jessica Pegula vs. Ann Li Head-to-Head Record

Jessica Pegula and Ann Li enter their US Open clash with the head-to-head finely balanced at 1-1. Their first meeting came back in 2018 at Lexington, where Li stunned her compatriot with a gritty comeback win. Seven years later, Pegula leveled the rivalry in strong fashion, dismissing Li in straight sets at Roland Garros 2025.

Year	Event	Round	Winner	Score
2025	Roland Garros	Round of 64	Jessica Pegula	6-3, 7-6(3)
2018	Lexington	Semifinals	Ann Li	2-6, 6-3, 6-4

Jessica Pegula vs. Ann Li Comparison

Jessica Pegula	Category	Ann Li
4	Current Ranking	58
471-264	Career W-L	254-174
37-16	YTD W-L	23-20
9	Career Titles	1
0	Grand Slams	0
3	YTD Titles	0

Jessica Pegula vs. Ann Li Prediction

Pegula’s experience at this stage of majors, combined with her clean serving stats and confidence-building run in New York, should allow her to handle Li’s challenge in straight sets.

Here’s to Jessica Pegula reaching her 55th Grand Slam Singles Main Draw match win! pic.twitter.com/oSzi8M60zC
— USTA (@usta) August 29, 2025

Prediction: Jessica Pegula in straight sets

Jessica Pegula vs. Ann Li US Open 2025 Betting Odds

The oddsmakers back Pegula heavily at 7/25, but Li at 14/5 with her recent form and fearless shot-making gives her an outside chance to turn this into a three-set thriller. Still, Pegula has the edge.

Here are the betting odds according to BetMGM:

Jessica Pegula: 7/25

Ann Li: 14/5

Here are the odds for total games as well as total sets for both players (sourced via BetMGM):

Total Sets Under 2.5: 4/9

Total Sets Over 2.5: 17/10

Total Games Under 22.5: 11/20

Total Game Over 22.5: 27/20

Pegula Set 1 Winner: 4/11

Li Set 1 Winner: 41/20

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

Mandatory Image Credit: Robert Deutsch-Imagn Images

Ann Li

Jessica Pegula

US Open 2025

Rudra Dubey

nfl

mma

I’m an academic turned sports writer from Raipur, India, specializing in the NFL, MMA, and tennis at The Playoffs. I previously wrote for Sportskeeda and hold a B.A. and M.A. in History. My journey into sports media began far from the field, rooted in the arts and sciences. Funny enough, I didn’t grow up a sports fan; I used to see it all as just noise. But a fateful writing job introduced me to the world of sports, and what began as a gig quickly became a passion. I understood those voices aren’t noise; they’re emotions of true sports fans, and now I am one of them, writing with the same energy I once questioned.