Jaguars and Colts face off for the top spot in the AFC South!
This Jaguars vs Colts AFC South divisional matchup promises to be an exciting one as both teams are currently tied in the division with 8 wins and 4 losses. The winner of this game will get a massive boost. With the Texans lurking just behind, a win on Sunday will be even more crucial.
Game Details:
| Recommended Bets | FanDuel | BetMGM |
|---|---|---|
| Jonathan Taylor Under 92.5 Rushing Yards | -114 | -113 |
| Daniel Jones Over 1.5 Touchdown Passes | +114 | +114 |
| Jacksonville Jaguars to win | +104 | +104 |
Jonathan Taylor is one of the best running backs in the league this season, but he has not rushed for 90 yards in the past couple of games. Moreover, the Jaguars’ run defense has risen to the top of the league, allowing just 989 yards from 12 games for an average of 82.4 rushing yards per game.
Daniel Jones has a total of 19 touchdown passes from 12 games, but more importantly, he has thrown for 2 or more touchdowns in 6 of those games. Ideally, the Colts may have to resort to the aerial route if the Jaguars are able to shut down their run game.
Both the Jaguars and the Colts are heading in opposite directions of late. While Jacksonville is currently on a three-game win streak, Indianapolis has lost 2 in a row. It is rather strange to see the Colts falter and lose the lead in the division after starting the season 8 and 2, but what that has done is given the momentum to Jacksonville.
AFC SOUTH BATTLE#INDvsJAX | @C_Anderson_Art pic.twitter.com/OsNNm79AvP
— Jacksonville Jaguars (@Jaguars) December 4, 2025
Initially, the way the season started for the Colts, it seemed that they would run away with the division. However, they have now lost three of their last four games, with the only win coming against the struggling Atlanta Falcons.
On the flip side, the Jaguars have taken control of the AFC South with three wins on the trot. That being said, Jacksonville’s wins have come against underperforming teams, but the momentum and home-field advantage could be enough to sway this game in their favor.
Prediction: Jacksonville Jaguars to win.
The moneyline and spread show the Indianapolis Colts are slight favorites in this matchup against the Jacksonville Jaguars. (Sourced from FanDuel).
| Moneyline | Spread | Total Points | |
|---|---|---|---|
| Jacksonville Jaguars | +104 | +1.5 (-108) | O 46.5 (-115) |
| Indianapolis Colts | -124 | -1.5 (-112) | U 46.5 (-105) |
Here are the over/under and best player bets for the Jacksonville Jaguars and the Indianapolis Colts, as per FanDuel.
Below are some of the best over/under bets for the Jacksonville Jaguars.
| Over/ Under Bets | Over | Under |
|---|---|---|
| Trevor Lawrence Pass Attempts | 32.5 (-120) | 32.5 (-106) |
| Brian Thomas Jr. Total Receptions | 3.5 (-130) | 3.5 (-102) |
| Travis Etienne Rush Attempts | 13.5 (-122) | 13.5 (-108) |
Below are some of the best player bets for the Jacksonville Jaguars.
If you’re looking for a complete guide to the best NFL betting sites, we’ve got you covered
day by day. pic.twitter.com/aQwAFIx1Ge
— Indianapolis Colts (@Colts) December 4, 2025
Below are some of the best over/under bets for the Indianapolis Colts.
| Over/ Under Bets | Over | Under |
|---|---|---|
| Daniel Jones Pass Attempts | 32.5 (-110) | 32.5 (-118) |
| Tyler Warren Total Receptions | 4.5 (-148) | 4.5 (+112) |
| Jonathan Taylor Rush Attempts | 20.5 (-114) | 20.5 (-114) |
Below are some of the best player bets for the Indianapolis Colts.
The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!
The over/under for total points in the Jaguars vs Colts game is set at 46.5.
The Colts come into the game as 1.5-point favorites over the Jaguars.
The Colts are the favorites with a moneyline of -124, while the Jaguars are the underdogs at +104.
Mandatory Credit: Imagn Images
nfl I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!
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