Dec 8, 2024; Santa Clara, California, USA; San Francisco 49ers running back Isaac Guerendo (31) runs in a touchdown during the fourth quarter against the Chicago Bears at Levi's Stadium. Mandatory Credit: Bob Kupbens-Imagn Images

nfl

Is Isaac Guerendo playing today? Updates on the 49ers RB availability for the Rams Game

Isaac Guerendo's Week 15 game status updates

The San Francisco 49ers face the Los Angeles Rams on Thursday Night Football in Week 15, but their running back room is in question. With injuries to key players like Christian McCaffrey and Jordan Mason, rookie Isaac Guerendo has become essential. However, his availability is uncertain after a foot injury in last week’s game.

Will Isaac Guerendo play against the Rams?

Isaac Guerendo is officially listed as questionable for Thursday’s game due to a sprained foot. He missed practice on Monday and Tuesday but returned on Wednesday as a limited participant. While this is a positive sign, his status remains uncertain.

Isaac Guerendo (foot) listed questionable for Thursday.
— Underdog NFL (@Underdog__NFL) December 11, 2024

However, with the fantasy football playoffs kicking off tonight, Guerendo has insisted he’s ready to go. According to Adam Schefter, he plans to play against the Rams, stating that he “feels good” despite the injury. This decision comes as a major boost for the 49ers, who rely on his speed and versatility to anchor their running game.

With the fantasy football playoffs starting tonight:

49ers rookie RB Isaac Guerendo plans to play Thursday night vs. the Rams despite his sprained foot that has left him being listed as questionable, per sources. Guerendo insists he “feels good.” pic.twitter.com/WClJ52lva3
— Adam Schefter (@AdamSchefter) December 12, 2024

The 49ers will wait until the inactives list is released, 90 minutes before kickoff, to make a final decision. If Guerendo can’t play, Patrick Taylor will step in as the lead back, with Ke’Shawn Vaughn and Israel Abanikanda providing additional depth.

How has Isaac Guerendo performed in 2024?

Guerendo’s rookie season has been impressive, especially given the 49ers’ injury struggles. He has totaled 324 rushing yards on 57 carries and scored four rushing touchdowns. In addition, he has added 69 receiving yards on seven receptions.

Last week against the Bears, Guerendo delivered a standout performance. He rushed 15 times for 78 yards and scored two touchdowns, along with catching two passes for 50 yards. This made him the first player this season to record a rushing touchdown and 50 receiving yards in the first quarter of a game.

Dre Greenlaw practiced in full on Wednesday (it was a walkthrough).

Nick Bosa and Isaac Guerendo were both limited on Wednesday, but were upgraded from earlier in the week.

Good chance #49ers get back Bosa and Guerendo, along with Greenlaw's debut.
— Akash Anavarathan (@akashanav) December 11, 2024

His speed (4.33 40-yard dash) and size (6’0”, 221 pounds) have made him a valuable asset in Kyle Shanahan’s system. However, with the short recovery window, his effectiveness—if he plays—could be limited.

Season stats: 324 rushing yards, 4 TDs, 69 receiving yards
Last game (Week 14 vs. Bears): 15 carries, 78 yards, 2 TDs; 2 catches, 50 yards

Isaac Guerendo’s availability is critical for the 49ers’ offense. If he plays, expect him to contribute significantly. If not, the team will rely on Patrick Taylor and others to fill the gap. Stay tuned for updates as game time approaches.

Is Isaac Guerendo playing today?

Isaac Guerendo

Isaac Guerendo questionable

Isaac Guerendo status

Isaac Guerendo Thursday Night Football

Isaac Guerendo TNF

Natasha Bose

I write about sports because, well, it brings in the big bucks! I’m not some lifelong analyst or stats guru, truth being told, you’ve probably never heard of me!—I just know how to research, write, and make things sound good. That’s the job!
Got into sports media the same way most people do: by (fortunate) accident. Started with SEO writing, took on a few sports gigs, and now here we are! I cover games, trades, player drama—whatever needs words.
Favorite part? The chaos. One day it’s a blockbuster trade, the next it’s a goat running onto the field. Never boring.
Message to readers: If you want deep analysis, there are people for that. If you want sharp, no-BS writing that actually makes sense, stick around.