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New York Giants vs San Francisco 49ers Predictions, Odds, and Best Bets for Week 9 NFL 2025-26 Season

Eric Divakaran
American Football / NFL
02/11/2025 – 19:00
New York Giants
VS
19:00
02/11/2025
San Francisco 49ers
Odds updated on November 1, 2025 at 10:05 am

The New York Giants will host the San Francisco 49ers for Week 9 matchup, live from MetLife Stadium. The Giants are currently 2-6 for the season, and one of the biggest reasons why is the injuries they’ve suffered. At first it was WR Malik Nabers, who’s out for the season with an ACL tear. Then it was their RB Cam Skattebo was suffered a gruesome leg injury, ending his season. The Giants have a decent squad with their QB1 Jaxson Dart leading the way. However, we may have to wait at least for a year before we see what they can achieve in full strength.

The 49ers are on a similar boat, dealing with multiple injuries to some of their key players, and that has continued to be the story for them since 2023 Super Bowl appearance. The 49ers are 2-3 in their last 5 games, with their latest loss coming to the Houston Texans. And we doubt their playoff chances with all the injuries they’re dealing with, most likely to get knocked out in the wildcard round, if they make the playoffs.

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Recommended Bets and Updated Odds

Recommended BetsFanduelBetMGM
Christian McCaffrey anytime TD scorer-220 -250
Mac Jones over 34.5 passing attempts-128-105
Mac Jones over 0.5 interceptions -130-145
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Rationale and Analysis

We expect Christian McCaffrey to score a TD at any time, looking at the Giants 25th ranked pass defense, allowing 9 rushing TDs so far, and the 49ers heavily relying on McCaffrey to make plays and score a TD. The Giants also rank 23rd in scoring defense and 22nd in red zone defense, making McCaffrey to score a safe bet.

Mac Jones could have higher than 34.5 passing attempt, as the Giants have a weak pass defense, sitting at 26th, allowing 245.3 yards on average. Jones has started for 6 games so far and has attempted 30 or more passes in 5/6 games.

Mac Jones could throw over 0.5 interceptions as he has thrown 4 INTs in the last three games, and his recent performance against the Texans, completing only 59.4% of his passes, suggests that he may thrown an INT again. Especially since he has tendencies to throw very risky passes at times.

Giants vs 49ers Prediction

We expect the 49ers to pull away with a win over the Giants, simply because of San Francisco’s far superior defensive unit, that can make multiple stops. The Giants are also missing some of their key players due to injuries, and the 49ers’ defense, plus their offense led by McCaffrey, should be enough to get the 49ers the win.

Prediction: 49ers win the game 27-24

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Week 9 Giants vs 49ers Betting Odds and Spread

Looking at the spread and the betting odds, the 49ers are the slight favorites to win the matchup against the Giants, as per BetMGM

TeamSpreadTotal PointsMoneyline
49ers -2.5 (-120)48.5 (-110)-155
Giants +2.5 (+100)48.5 (-110)+130
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Giants vs 49ers Best Bets

Here are some of the best player bets and over/under for the New York Giants and the San Francisco 49ers, as per BetMGM

New York Giants Over/Under Odds

Listed below are over/under odds for the New York Giants, as per BetMGM

Over/Under BetsOverUnder
Jaxson Dart to throw INTs0.5 (-145) 0.5 (+110)
Jaxson Dart longest pass completion 35.5 (-115)35.5 (-115)
Wan’Dale Robins receptions made5.5 (+105)5.5 (-145)

New York Giants Best Player Bets

Here are some of the best player bets for the New York Giants, as per BetMGM

  • Jaxson Dart to throw under 1.5 passing TDs: -165
  • Tyrone Tracy Jr. anytime TD scorer: -110
  • Jaxson Dart under 20.5 pass completion: -130

San Francisco 49ers Over/Under Odds

Here are some of the over/under odds for the game, as per BetMGM

Over/Under BetsOverUnder
Christian McCaffrey rushing attempts19.5 (-110)19.5 (-120)
Christian McCaffrey longest rush 15.5 (-135) 15.5 (+100)
Mac Jones passing TDs 1.5 (-145) 1.5 (+110)

San Francisco Best Player Bets

Here are some of the best player bets for the San Francisco 49ers, as per BetMGM

  • Christian McCaffrey anytime TD scorer: -250
  • First TD scorer Christian McCaffrey: +350
  • George Kittle anytime TD scorer: +135
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FAQs

Who is favored to win between the Giants vs 49ers?
The 49ers are 2.5-point favorites to win the matchup against Giants.

What is the over/under total for the game?
The over/under for total points is set at 48.5.

What is the predicted score for the Giants vs 49ers game?
We expect the 49ers to take down the Giants in a close battle, and the Final score to be 27-24.

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I cover the National Football League and things cannot get better than that. I always dreamed to play football or basketball professionally since I’m built like a Running Back. But now that I can’t, since I’m technically in the “Unc” age, I thought why not pick a career in sports industry? So here I am, doing what I love, and hoping that the Commanders win the Super Bowl. I give love to players when it’s due, but can be critical about their performances at the same time. Enough about me, now let my articles do all the talking. 

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