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Miami Dolphins vs Buffalo Bills Predictions, Odds, and Best Bets for Week 10 NFL 2025-26 Season

Eric Divakaran
American Football / NFL
09/11/2025 – 19:00
Miami Dolphins
VS
19:00
09/11/2025
Buffalo Bills
Odds updated on November 6, 2025 at 10:13 pm

The Miami Dolphins are set to host the Buffalo Bills for their Week 10 matchup, in this AFC East rivalry game. The Dolphins come into this matchup after losing to the Baltimore Ravens in Week 9, making them 2-7 for the season so far. Nothing has been going right for them, with the Tyreek Hill’s season-ending injury, Tua Tagovailoa’s turnover prone passing game, or their head coach Mike McDaniel’s coaching. We expect huge changes for the Dolphins in the offseason next year, but till then they’ll have to survive with what they have.

The Buffalo Bills are coming into this matchup, after a very impressive win against the Kansas City Chiefs and Patrick Mahomes, who knocked them off the AFC championship round last season. Josh Allen has put up a stellar season after his MVP campaign in 2024 and with Khalil Shakir, James Cook having a decent year, the Bills have a chance to win it all. They are 6-2 for the season, and are just a game away from reclaiming the No.1 spot in the AFC East.

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Recommended Bets and Updated Odds

Recommended BetsFanduelBetMGM
Khalil Shakir under 47.5 receiving yards -114-115
Tua Tagovailoa over 0.5 interceptions -184-155
Josh Allen Over 5.5 rushing attempts+110-120
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Analysis and Rationale

Khalil Shakir is bound to stay under 47.5 receiving yards as in 5 of 8 games, he’s stayed under 47.5 yards, getting targeted less than 10 times. The Dolphins rank 10th in passing defense, but are horrible against the rush, ranking 30th. This makes us believe that the Bills will use their run game much more than passing, making this a safe bet.

Facing top-tier competition this season, Tua has thrown at least one interception, going against teams like the Bills, Patriots, Ravens, Colts, Chargers, or a great defensive team like the Brown. In 9 games, Tagovailoa has already thrown 11 interceptions, and looking at the Bills’ who rank 4th in total INTs this season, we expect him to throw one or more INTs in this game.

Josh Allen is bound to cross 5.5 rushing attempts as he’s at at least 6 rush attempts or more in 6/8 games so far, and looking at the Dolphins’ weak rush defense, we expect Allen to run with the football more in this game. In the last two games, Allen has scored 4 rushing TDs and we do not expect him to stop this streak against the Dolphins, who rank 30th against the rushing game.

Dolphins vs Bills Prediction

We expect the Bills to dominate the matchup against the Miami Dolphins, as they are the far superior team in almost every aspect. While the Bills have shown vulnerabilities with their defense, it takes a lot of explosive offensive capabilities to knock them off, and the Dolphins just do not have an answer for it, with Tyreek Hill out for the rest of the season. Therefore, the Bills should just be too much to handle for Miami and Mike McDaniel, who lost their Week 2 matchup against Buffalo earlier this season.

Prediction: Bills win the game 40-10

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Week 10 Dolphins vs Bills Spread and Betting Odds

Looking at the spread and the moneyline, the Bills are the overwhelming favorites to beat the Dolphins, as per BetMGM

TeamsSpreadTotal PointsMoneyline
Bills-9.5 (-110)50 (-110)-500
Dolphins+9.5 (-110)50 (-110)+375
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Dolphins vs Bills Best Bets

Here are some of the best player bets and the over/under odds for the Miami Dolphins and the Buffalo Bills, as per BetMGM.

Miami Dolphins Over/Under Odds

Listed below are over/under odds for the Miami Dolphins, as per BetMGM.

Over/Under BetsOverUnder
Jaylen Waddle receiving yards 61.5 (-115)61.5 (-115)
Tua Tagovailoa passing yards 219.5 (-115)219.5 (-115)
De’Von Achane rushing yards62.5 (-115)62.5 (-118)

Miami Dolphins Best Player Bets

Here are some of the best player bets for the Miami Dolphins, as per BetMGM.

  • Tua Tagovailoa over 0.5 interceptions thrown: -155
  • De’Von Achane anytime TD scorer: -135
  • Tua Tagovailoa under 1.5 passing TDs: -175

Buffalo Bills Over/Under Odds

Below listed are over/under for the Buffalo Bills, as per BetMGM.

Over/Under BetsOverUnder
Khalil Shakir receiving yards46.5 (-118)48.5 (-110)
Josh Allen passing yards 231.5 (-115)231.5 (-115)
James Cook rushing yards88.5 (-115)88.5 (-115)

Buffalo Bills Best Player Bets

Here are some of the best player bets for the Buffalo Bills, as per BetMGM.

  • Josh Allen over 1.5 passing TDs: -160
  • James Cook anytime TD scorer: -185
  • Khalil Shakir over 4.5 receptions made: -150
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FAQs

Who is favored to win between the Dolphins vs Bills?
The Bills are 9.5-point favorites to win the matchup against Dolphins.

What is the over/under total for the game?
The over/under for total points is set at 50

What is the predicted score for the Dolphins vs Bills game?
We expect the Bills to take down the Dolphins in a blowout victory, and the Final score to be 40-10.

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I cover the National Football League and things cannot get better than that. I always dreamed to play football or basketball professionally since I’m built like a Running Back. But now that I can’t, since I’m technically in the “Unc” age, I thought why not pick a career in sports industry? So here I am, doing what I love, and hoping that the Commanders win the Super Bowl. I give love to players when it’s due, but can be critical about their performances at the same time. Enough about me, now let my articles do all the talking. 

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