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Cleveland Cavaliers vs Indiana Pacers Predictions, Betting Odds and Best Bets for Friday, November 21

The Cleveland Cavaliers will welcome the Indiana Pacers for an NBA Cup group stage game on Friday, November 21. The Cavs will head into the game on the back of a significant loss to the Houston Rockets. On the other hand, the Indiana Pacers put an end to their seven-game losing skid and defeated the Charlotte Hornets to add a second win to their tally.

Game Details

Date: Friday, November 21, 2025
Time: 7 pm ET
Location: Rocket Arena, Ohio
TV: Amazon Prime Video
Live Stream: NBA League Pass

Recommended Bets and Odds

Recommended Bet	FanDuel	BetMGM
Donovan Mitchell O 28.5 points	-108	–

Analysis and Rationale

Donovan Mitchell has been leading the Cleveland Cavaliers in scoring, assists and blocks. He has been averaging 30.2 points per game, while shooting 50.7% from the field and 38.5% from the three-point range. In the previous game, Mitchell was limited to 21 points on 47.1% shooting from the field and 33.3% shooting from the three-point range. However, he has had three consecutive games with over 30 points before that.

Considering that the Cavaliers are one of the strongest teams in the season, while the Pacers are barely managing to survive along with the fact that the former have homecourt advantage, we can expect Mitchell to drop 29 points or more on Friday.

Cleveland Cavaliers vs Indiana Pacers Predictions

The Cleveland Cavaliers finished the previous season as Eastern Conference toppers with 64 wins and 18 losses. After finishing as conference semifinalists, the Cavs are aiming to bridge the gap this season. They kicked off the season with a defeat and had a few hiccups in the beginning, but it didn’t take them much time to get back on track. Currently, they are seeded fourth in the conference standings with a 10-4 win-loss record.

They have an offensive rating of 116.2, which places them in the 13th spot of the standings. Their defensive rating of 112.3 puts them in the 10th spot in the standings.

On the other hand, the Indiana Pacers, have had a remarkable 2024-25 season where they finished as the finalists. They gave a tough competition to their rivals, OKC Thunder till Game 7, but lost Tyrese Haliburton to an Achilles tear. Heading into the current season, they were hopeful of repeating their heroics. However, an injury-riddled roster quashed their hopes and they are currently sitting in the bottom part of the standings.

With only two wins in 15 games, the Pacers have the second-worst offensive rating of 106.0, and the fifth worst defensive rating of 119.1.

There is no doubt that the Cavaliers are in great form, and Darius Garland’s return will give them a boost. Moreover, their momentum and homecourt advantage makes them favorites to win the upcoming game against the Pacers.

Predictions: Indiana Pacers to win.

Cleveland Cavaliers vs Indiana Pacers Betting Odds and Spread

	Spread	Moneyline	Odds
Indiana Pacers	+13.5 (-110)	+610	O 237.5 (-112)
Cleveland Cavaliers	-13.5 (-110)	-900	U 237.5 (-108)

Cleveland Cavaliers vs Indiana Pacers Over/Under Odds and Best Bets

Cleveland Cavaliers Over/Under Odds

Recommended Bets	Over	Under
Darius Garland 16.5 points	+100	-132
Evan Mobley 19.5 points	-106	-125
Jarrett Allen 8.5 rebounds	-102	-130

Cleveland Cavaliers Best Bets

Evan Mobley to record 12+ rebounds: +290
De’Andre Hunter to score 20+ points : +158
Donovan Mitchell to record 8+ assists: +400

Indiana Pacers Over/Under Odds

Recommended Bets	Over	Under
Pascal Siakam 23.5 points	-118	-112
Bennedict Mathurin 21.5 points	-125	-106
Isaiah Jackson 6.5 rebounds	+112	-148

Indiana Pacers Best Bets

Andrew Nembhard to record 20+ points: +215
Pascal Siakam to record 6+ assists: +265
Andrew Nembhard to record a double-double: +400

The odds given above have been sourced from FanDuel. Use FanDuel to ace your betting game across all sports.

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FAQs

What is the over/under for total points for the Cavs vs Pacers game?

The over/under for total points in the game between the Cavs vs Pacers is set at 237.5.

What is the point spread for the Cavs vs Pacers game?

The Cavs have a heavy 13.5 point edge over the Pacers.

What is the moneyline for the Cavs vs Pacers game on Friday?

The Cavs are favorites to win with moneyline odds of -820, while the Pacers are underdogs at +570.

Garima Ranawat

Garima is a sports writer with around two years of experience in Indian sports and a newfound interest in the NBA. Inspired by the leadership of cricketing legend MS Dhoni, she wishes to bring in newer perspectives to the NBA fanatics with her writing.