Los Angeles Chargers vs Las Vegas Raiders Preview, Betting Odds, and Predictions – NFL 2025-26 Season Week 2

The Los Angeles Chargers are back from their trip to Sao Paulo, Brazil, and will now immediately be travelling on the road to take on the Las Vegas Raiders for Monday Night Football action. For the Chargers, they are coming off a 1-0 start and are looking forward to building on the momentum they in Week 1.

Meanwhile, the Las Vegas Raiders are also 1-0 to start the season, looking to build on further. They have a lot of star power on their end, potentially having two or three superstars for the future. However, the Raiders still have a long season to go and it is only just getting started.

Recommended Bets	FanDuel	BetMGM
Ashton Jeanty Under 68.5 rushing yards	-114	-118
Justin Herbert Over 33.5 passing attempts	-114	-125
Omarion Hampton Over 13.5 rushing attempts	-148	-135

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Analysis and Rationale

In the Raiders-Chargers matchup, rookie Ashton Jeanty may struggle to exceed 68 rushing yards because, he gained just 38 on 19 carriers in Week 1 against New England’s defense, averaging 2.0 yards per attempt due to poor blocking. The Chargers’ strong defense, which held the the Chiefs to under 100 rushing yards in their opener, should contain him further in this divisional clash.

In the Chargers-Raiders divisional clash, Justin Herbert is poised to exceed 33 passing attempts. He threw 34 in Week 1’s in over the Chiefs, completing 25 for 318 yards and three touchdowns. Facing a Raiders team that allowed 276 passing yards on 30-46 attempts last week. The Chargers should be able to exploit the Chargers’ defense quite easily.

Omarion Hampton should surpass 13.5 rushing attempts due to 15 carries for 67 yards in Week 1. The Raiders run defense allowed 112 yards last week, suggesting Hampton to go off in the game.

Chargers vs Raiders Preview

In a high-stakes AFC West showdown on Mondey Night Football, the 1-0 Chargers visit the 1-0 Las Vegas Raiders at Allegiant Stadium. Just Herbert dazzled in Week 1 with 318 passing yards and three touchdowns against Kansas City.

herbo was ready this time 😭 pic.twitter.com/zTPWSqxMpW
— Los Angeles Chargers (@chargers) September 13, 2025

Th Raiders, fresh off a close win, lean on Ashton Jeanty’s 38-yard debut performance and tight end Brock Bowers’ potential breakout.

Los Angeles Chargers Best Bets – Over/Under and Player Bets

Here are over/under and best player bets for the Los Angeles Chargers, according to BetMGM

Over/ Under Bets	Over	Under
Justin Herbert Passing Yards	254.5 (-115)	254.5 (-118)
Ladd McConkey Receiving Yards	72.5 (-115)	72.5 (-115)
Omarion Hampton	53.5 (-130)	53.5 (-105)

Los Angeles Chargers Best Player Bets

Below are some of the best player bets for the Los Angeles Chargers, according to BetMGM

Omarion Hampton Anytime touchdown scorer: -135
Justin Herbert to throw Under 0.5 interceptions: -160
Omarion Hampton Rushing Yards Over 53.5: -130

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Las Vegas Raiders Best Bets – Over/Under and Player Bets

Here are over/under and best player bets for the Las Vegas Raiders, according to BetMGM

Over/ Under Bets	Over	Under
Geno Smith Passing Yards	254.5 (-115)	254.5 (-118)
Jakobi Meyers Receiving Yards	67.5 (-110)	67.5 (-118)
Ashton Jeanty Rushing Yards	68.5 (-115)	68.5 (-115)

Las Vegas Raiders Best Player Bets

Below are some of the best player bets for the Las Vegas Raiders, according to BetMGM

Ashton Jeanty Anytime touchdown scorer: -125
Geno Smith to rush for Over 7.5 yards: -125
Geno Smith throw under 1.5 passing touchdowns: -140

Chargers vs Raiders Prediction for the 2025-26 NFL Season

In the AFC West showdown on Monday Night Football, we expect the 1-0 Chargers to get past the Raiders. Justin Herbert’s efficiency passing and Harbaugh’s run-heavy attack could exploit Las Vegas’ secondary. While we do think that the Raiders will keep it close with Jeanty’s ground game. Los Angeles should be able to pull away for a 2-0 start to their season.

Prediction: Chargers to win the game

Preppin’ for Primetime #LACvsLV pic.twitter.com/Ie1jZBFBTe
— Las Vegas Raiders (@Raiders) September 12, 2025

Chargers vs Raiders Betting Odds and Spread

The spread and the moneyline shows that the Chargers are the favorites to win the ball game against the Raiders, according to BetMGM

Teams	Spread	Total Points	Moneyline
Chargers	-3.5 (-105)	46.5 (-110)	-190
Raiders	+3.5 (-115)	46.5 (-110)	+155

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

FAQs

Who is favored to win the Chargers vs Raiders game?
Chargers are favored by 3.5 points to win the game.

What is the over/under total points for Chargers vs Raiders game?
The total points is set at 46.5 for the Chargers vs Raiders game.

What is the moneyline for the Chargers vs Raiders game?
The moneyline is set at Chargers (-190), and Raiders at (+155).

Eric Divakaran

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I cover the National Football League and things cannot get better than that. I always dreamed to play football or basketball professionally since I’m built like a Running Back. But now that I can’t, since I’m technically in the “Unc” age, I thought why not pick a career in sports industry? So here I am, doing what I love, and hoping that the Commanders win the Super Bowl. I give love to players when it’s due, but can be critical about their performances at the same time. Enough about me, now let my articles do all the talking.