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Chargers vs Cardinals Prediction, Picks, Odds, Spread: Can Justin Herbert lead the Chargers to another win?

Natasha Bose

With a solid performance in recent games, will Justin Herbert and the Chargers maintain their momentum?

After a strong showing in Week 6, Justin Herbert and the Chargers are heading to Glendale to take on the Arizona Cardinals (2-4), aiming to build on their 3-2 record.

Here is an early look at Chargers vs Cardinals prediction, picks, and odds.

For this Monday Night Football matchup, the Los Angeles Chargers (3-2) are the slight favorites (-1) after a narrow victory last week. Despite the close odds, the Chargers’ defense, ranked first in points allowed, will be a critical factor as they face Kyler Murray and the Cardinals.

Los Angeles Chargers vs Arizona Cardinals: Odds and Betting Lines

  • Favorite: Chargers (-1)
  • Underdog: Cardinals (+1)
  • Over/Under: 44
  • Spread: -1 (Chargers)

Los Angeles Chargers vs Arizona Cardinals: Live Streaming Info & Game Details

  • Game Day: Monday, October 21, 2024
  • Game Time: 9:00 p.m. ET
  • Stadium: State Farm Stadium, Glendale, AZ
  • TV Channel: ESPN+
  • Live Stream: FOX Sports

Chargers vs Cardinals: Our prediction

The Chargers have been inconsistent offensively, ranking 31st in points scored but have excelled defensively, allowing the fewest points per game this season. J.K. Dobbins will play a crucial role on the ground, averaging 87.6 rushing yards per game, while Justin Herbert will need to overcome the Cardinals’ struggling pass defense, ranked 23rd in the NFL.

The Cardinals, led by Kyler Murray, have shown flashes of brilliance but have struggled defensively, allowing an average of 153 rushing yards per game. This could open opportunities for Dobbins and the Chargers’ run game to control the clock.

On the other hand, Arizona’s offense, ranked 21st in points scored, may struggle against the Chargers’ top-ranked defense. Kyler Murray has been efficient, passing for 1,186 yards with eight touchdowns, but his two interceptions and the team’s struggles in closing games could be problematic.

For bets, the Chargers should cover the -1 spread, with a tight game likely leaning under the total of 44 points. The Cardinals may put up a fight, but Los Angeles’ defense should secure the win.

READ MORE: Buccaneers vs Ravens Prediction, Picks, Odds, Spread: Can Baker Mayfield outshine Lamar Jackson?

Image Credit: © Ron Chenoy-Imagn Images

I write about sports because, well, it brings in the big bucks! I’m not some lifelong analyst or stats guru, truth being told, you've probably never heard of me!—I just know how to research, write, and make things sound good. That’s the job!
Got into sports media the same way most people do: by (fortunate) accident. Started with SEO writing, took on a few sports gigs, and now here we are! I cover games, trades, player drama—whatever needs words.
Favorite part? The chaos. One day it's a blockbuster trade, the next it's a goat running onto the field. Never boring.
Message to readers: If you want deep analysis, there are people for that. If you want sharp, no-BS writing that actually makes sense, stick around.

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