Arizona Cardinals vs Seattle Seahawks Preview, Predictions and Betting Odds – Week 4 Thursday Night Football 2025-26 NFL Season

The Seattle Seahawks are travelling on the road to take on the Arizona Cardinals for Week 4’s Thursday Night Football action of the 2025-26 season. This NFC West battle features the 2-1 Cardinals going up against the 2-1 Seahawks, with the Cardinals coming off heartbreaking loss to the depleted 49ers squad in Week 3, while the Seahawks are coming off a dominant performance after ripping apart the New Orleans Saints.

IT'S RIVALRY WEEK. pic.twitter.com/2Jb0ntfGJ8
— Arizona Cardinals (@AZCardinals) September 23, 2025

This matchup between the two is expected to be a very tight matchup as no team is the clear favorite to run away with the win. This contest will also feature two of the best quarterbacks going against one another, featuring Arizona’s Kyler Murray pitted against Seattle’s Sam Darnold.

Recommended Bets	FanDuel	BetMGM
Kenneth Walker Anytime Touchdown Scorer	+110	-120
Jaxson Smith-Njigba Anytime Touchdown Scorer	+160	+155
Marvin Harrison Jr. Under 45.5 Receiving Yards	-114	-115

FanDuel

High total bonus ceiling

Daily second-chance bet protection

No promo code required

$150

Welcome offer

Bet $5 & Get $150 in Bonus Bets

Click to reveal code

COPIED

F A N D U V I P

Claim now

New customers only. Must be 21+ in most jurisdictions, but 18+ in DC, KY, and WY. Offer is valid only in eligible regulated states/jurisdictions and not available in AR; void where prohibited. First online real-money wager only; cashed-out or bonus-funded bets are excluded.

Analysis and Rationale

Kenneth Walker III’s anytime TD bet shines after a rocky Week 1 with 10 carries, 20 yards, 0 TDs, but he rebounded explosively in Week 2 with 13 carries, 105 yards, a TD. Similarly in Week 3, he wounded up with 16 carries. 38 yards, and 2 TDs. With 3 scores in 2 games, he’s Seattle’s red-zone hammer, facing vulnerable Cardinals run defense.

Jaxson Smith-Njigba’s anytime TD bet surges because he’s a frequent target for his QB Sam Darnold, and so far Njigba’s already caught 22 passes, and has 323 receiving yards with a TD. He’s Seattle top target and looking at the Cardinals’ pass defense, we believe that Smith Njigba has a great chance to score in this game.

Marvin Harrison Jr. has not had the best start to this season, recording only 142 yards in three games so far (44, 27, and 71 receiving yards in Weeks 1, 2, and 3), and a TD. In Cardinals’ last game against the 49ers, Harrison Jr. dropped a very open and a deep throw by his QB, which could have led to a TD for him. He was utterly disappointed in himself, and even said, “I’m not doing my job at a high-enough level.” We believe that Harrison Jr. may still be shaken up after dropping that catch, and the fact that he’s only been targeted 10 times so far, makes us believe that he’ll stay under 45.5 receiving yards.

Cardinals vs Seahawks Preview

In a crucial NFC West clash in Thursday Night Football, the 2-1 Arizona Cardinals face the 2-1 Seattle Seahawks. The Cardinals with Kyler Murray’s play, will try to take down the Seahawks. However, they are hard hit by James Conner’s season-ending foot injury. Meanwhile the Seahawks, fresh off a 44-13 rout of the Saints, have won 7 straight against Arizona since the 2020 season. This game is expected to be a tightly knit contest between the two teams, but the Seahawks may have a slightly greater advantage looking the roster construction.

Cardinals vs Seahawks Prediction

We expect the Seahawks to take down the Cardinals in this TNF action. The Cardinals have been horrible defensively this season, ranking 23rd in terms of total defense. And when it comes to their offense, they are further below sitting at 25th for the season. Meanwhile, the Seahawks are sitting at 14th in terms of total defense, and their offensive line deserves a lot of credit, protecting their QB way better than we expected them to.

Looking at the fact that the Cardinals have lost 7 straight games against the Seahawks, and the James Conner injury, makes us believe that the Seahawks will run away with a win.

Prediction: Seattle to win the game 24-21.

A #TNFonPrime rivalry showdown 😤 pic.twitter.com/LsSak5HDKn
— NFL on Prime Video (@NFLonPrime) September 23, 2025

Cardinals vs Seahawks Betting Odds

Here are the best bets and over/under betting odds for the Arizona Cardinals and the Seattle Seahawks, according to BetMGM

Arizona Cardinals Over/Under Odds

Below are over/under odds for the Arizona Cardinals, as per BetMGM

Over/Under Bets	Over	Under
Kyler Murray Passing Yards	216.5 (-115)	216.5 (-115)
Trey Mcbride Receiving Yards	64.5 (-115)	64.5 (-118)
Trey Benson Rushing Yards	60.5 (-118)	60.5 (-110)

Arizona Cardinals Best Player Bets

Listed below are some of the best player bets for the Arizona Cardinals, according to BetMGM

Kyler Murray Pass Completions Under 21.5- -130
Trey Benson Under 15.5 Rushing attempts: -130
Marvin Harrison Jr Under 20.5 longest reception: -125

BetMGM

All in one gambling website

Reputable gambling name

Multiple betting features including live streaming

$1,500

Welcome offer

Get up to $1,500 Back in Bonus Bets

Click to copy code

COPIED

TPOVIP

Claim now

21+. AZ/CO/IL/IN/IA/KS/LA/MD/MA/MI/NJ/OH/PA/TN/ VA/WV/WY only. Offer not available in DC/MS/NV/NY/PR. New customers only. Qualifying deposit (min $10) and first real money wager required. If qualifying bet settles as a loss, user is refunded 100% in non-withdrawable bonus bets up to $1,500. Full T&Cs can be found on betmgm.com.

Seattle Seahawks Over/Under Odds

Below are over/under odds for the Seattle Seahawks, as per BetMGM

Over/Under Bets	Over	Under
Sam Darnold Passing Yards	218.5 (-115)	218.5 (-115)
Jaxon Smith Njigba Receiving Yards	81.5 (-115)	81.5 (-115)
Sam Darnold Rushing Yards	7.5 (-110)	7.5 (-120)

Seattle Seahawks Best Player Bets

Listed below are some of the best player bets for the Seattle Seahawks, according to BetMGM

Sam Darnold under 0.5 interceptions thrown: -135
Kenneth Walker Anytime TD scorer: -120
Sam Darnold over 1.5 passing touchdowns: +150

Cardinals vs Seahawks Spread and Betting Odds

The betting odds and the spread show that the Seattle Seahawks are only a slight favorite to win this matchup against the Cardinals, as per BetMGM

Teams	Spread	Total Points	Moneyline
Seahawks	-1.5 (-110)	43.5 (-110)	-125
Cardinals	+1.5 (-110)	43.5 (-110)	+105

BetMGM

All in one gambling website

Reputable gambling name

Multiple betting features including live streaming

$1,500

Welcome offer

Get up to $1,500 Back in Bonus Bets

Click to copy code

COPIED

TPOVIP

Claim now

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

FAQs

Who is favored to win between the Cardinals and the Seahawks?
Seahawks are slim 1.5-point road favorites over the Cardinals.

What is the over/under total for the game?
The over/under for total points is set at 43.5.

What are the key player injuries in this game?
Cardinals’ RB James Conner is out for the season with a gruesome ankle injury.

Eric Divakaran

nba

nfl

mma

I cover the National Football League and things cannot get better than that. I always dreamed to play football or basketball professionally since I’m built like a Running Back. But now that I can’t, since I’m technically in the “Unc” age, I thought why not pick a career in sports industry? So here I am, doing what I love, and hoping that the Commanders win the Super Bowl. I give love to players when it’s due, but can be critical about their performances at the same time. Enough about me, now let my articles do all the talking.