Broncos vs Jaguars Predictions, Odds and Best Bets For Week 16 of the 2025-26 NFL Season

Two teams from the AFC that have surprised many by getting to this stage of the regular season and having a dominant win-loss record face off this week. The Denver Broncos host the Jacksonville Jaguars in a massive AFC clash that could have playoff seeding ramifications depending on the result.

The Broncos are 12-2 and currently hold the number one seed in the AFC, but the Jaguars are the leaders of the AFC South and boast a 10-4 record. An intriguing clash awaits us in this Week 16 fixture.

Game Details:

Time: 4:05 p.m. ET
Date: Sunday, December 21, 2025
Location: Empower Field at Mile High, Denver, Colorado
TV Channel: FOX
Streaming: Fubo, NFL Sunday Ticket on YouTube, NFL+

Another marquee matchup at home. 🏡#JAXvsDEN coming 🔜 pic.twitter.com/d0K8TlKmaZ
— Denver Broncos (@Broncos) December 19, 2025

Recommended bets and updated odds

Recommended Bets	FanDuel	BetMGM
Trevor Lawrence Under 223.5 Passing Yards	-114	-113
RJ Harvey Anytime TD scorer	-120	-112
Total Points Over 46.5	-110	-110

Analysis and Rationale

So far this season, Trevor Lawrence has struggled to put up extensive passing yards against top-quality defenses. For example, Lawrence was restricted to 158 yards by the Texans and 153 yards by the Chargers. Denver has a top ten pass defense and one of the more elite defenses overall.

Broncos’ running back RJ Harvey has seen an increase in production over the past few games as the premier back due to the injury to JK Dobbins. He has a total of 6 rushing touchdowns, but 4 of them have come in the last three games.

The Denver Broncos have one of the top defenses in the league; in fact, they are tied for second in scoring defense, giving up just 18.6 points per game. However, they have dominated the weaker offensive teams for the most part and have given up an average of 23 points in the last three games.

As for Jacksonville, they are allowing around 21 points per game on defense, but their offensive production has gone up a notch lately. Their last three games have resulted in 109 points against the Titans, Colts, and Jets.

Broncos vs Jaguars Prediction

This Week 16 clash between the Broncos and the Jaguars is another critical one with respect to the season ahead. With the playoffs on the horizon, Denver is looking to lock down the number one seed in the AFC, whereas the Jaguars are looking to hold on to the lead in the AFC South.

Denver is currently on an 11-game win streak and has an incredible defense. While Trevor Lawrence had the game of his career last week against the Jets, this week will be a completely different challenge, facing the Broncos’ elite defense.

Prediction: Denver Broncos to win.

Week 16 Broncos vs Jaguars Betting Odds and Spread

The moneyline and spread show the Denver Broncos are slight favorites in this matchup against the Jacksonville Jaguars. (Sourced from FanDuel).

	Moneyline	Spread	Total Points
Denver Broncos	-178	-3.5 (-102)	O 46.5 (-115)
Jacksonville Jaguars	+150	+3.5 (-120)	U 46.5 (-105)

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Broncos vs Jaguars Best Bets

Here are the over/under and best player bets for the Denver Broncos and the Jacksonville Jaguars, as per FanDuel.

Denver Broncos Over/Under Odds

Below are some of the best over/under bets for the Denver Broncos.

Over/ Under Bets	Over	Under
Trevor Lawrence Pass Attempts	33.5 (+104)	33.5 (-135)
Courtland Sutton Total Receptions	4.5 (-136)	4.5 (+102)
RJ Harvey Rush Attempts	14.5 (-122)	14.5 (-108)

Denver Broncos Best Player Bets

Below are some of the best player bets for the Denver Broncos.

Bo Nix 200+ Passing Yards: -280
Courtland Sutton Most Receiving Yards: +240
RJ Harvey 50+ Rushing Yards: -132

If you’re looking for a complete guide to the best NFL betting sites, we’ve got you covered

Red Rocks, how we feelin'?#JAXvsDEN pic.twitter.com/sb7OZdo6E4
— Jacksonville Jaguars (@Jaguars) December 18, 2025

Jacksonville Jaguars Over/Under Odds

Below are some of the best over/under bets for the Jacksonville Jaguars.

Over/ Under Bets	Over	Under
Bo Nix Pass Attempts	36.5 (+104)	36.5 (-135)
Brian Thomas Jr. Total Receptions	3.5 (-120)	3.5 (-110)
Travis Etienne Jr. Rush Attempts	15.5 (-104)	15.5 (-128)

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Jacksonville Jaguars Best Player Bets

Below are some of the best player bets for the Jacksonville Jaguars.

Trevor Lawrence Under 223.5 Passing Yards: -114
Jakobi Meyers 50+ Receiving Yards: -162
Travis Etienne Jr. 40+ Rushing Yards: -420

The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

FAQs

What is the over/under for total points for the Broncos vs Jaguars game?

The over/under for total points in the Broncos vs Jaguars game is set at 46.5.

What is the point spread for the Broncos vs Jaguars game?

The Broncos come into the game as 3.5-point favorites over the Jaguars.

What is the moneyline for the Broncos vs Jaguars game?

The Broncos are the favorites with a moneyline of -178, while the Jaguars are the underdogs at +150.

Mandatory Credit: [Corey Perrine/Florida Times-Union] Imagn Images

Devavrat Kulkarni

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I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!