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Denver Broncos vs Los Angeles Chargers Picks, Predictions, Odds and Best Bets for NFL 2025-26 Season

Eric Divakaran

The Denver Broncos host the Los Angeles Chargers for an exciting AFC West rivalry matchup on Sunday. This matchup features two teams headed to the playoffs and are some of the powerhouse teams in the NFL, however, with the division title out of reach for the playoffs, this game carries less weight compared to the others we have or will witness in this final week.

Our Broncos vs Chargers picks highlight where the value stands for spread, total, and player props, plus a same-game parlay to round things out.

Broncos vs Chargers Picks and Predictions

Expert Pick: Denver Broncos Moneyline (-1100)

Book: Best price at BetMGM

For our expert pick, we chose the Denver Broncos to win the game, and the reason why is largely due to the fact that Chargers’ QB1 Justin Herbert and select starters will not play in this game and will rest, since the Charger, win/lose, will be headed to the wildcard round with the divisional title out of reach.

Meanwhile, the Broncos have a lot to gain with a win, since they will capture the No.1 seed at AFC if they manage to take out the Chargers who will be missing a lot of players due to injury or rest. They control their seeding fate going into the final week of the 2025-26 NFL regular season and you can expect their A game in this matchup.

Best Bets for Broncos vs Chargers

Best Bet #1: Trey Lance Under 163.5 Passing Yards

The reason for Broncos’ success this season has been their stout defense which has maintained its top 10 passing defense all season long. Allowing only 192.4 yards per game and 18 passing TDs, they are in position to win the AFC’s No.1 seed and while the Chargers are excellent on the offensive end, they are missing a bunch of players including Omarion Hampton, Keenan Allen, Derius Davis, Khalil Mack, and Kimani Vidal, which could cripple the Chargers’ offense, ultimately leading to less than 163.5 yards. Their QB Trey Lance has also not started a single game this season and has never crossed even 50 passing yards so far, which makes this a great bet.

Best Bet #2: R.J. Harvey under 56.5 rushing yards

R.J. Harvey has only four games beyond 56.5 yards this season and has not yet crossed 100 plus yards in his career. He averages 3.9 rushing yards per attempt and 8.2 attempts per game, which indicates that he does not get a lot of touches in a single game. Also, the Chargers have an excellent rushing defense that only allows 104.7 yards per game, which makes us believe this is a reasonable bet.

Player Props to Target

Here are some of best player props to place your bet on for Sunday’s game.

Passing Prop

  • Trey Lance under 28.5 passing attempts: -135
  • Bo Nix under 1.5 passing touchdowns: -130

Rushing Prop

  • RJ Harvey under 15.5 rushing attempts: -140
  • Trey Lance under 8.5 rushing attempts: -110

Receiving Prop

  • Courtland Sutton under 4.5 receptions made: -145
  • Courtland Sutton to get 75+ yards: +140

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Same-Game Parlay

Here are same-game parlays for the game between Broncos vs Chargers, as per FanDuel.

Same-Game Parlay 1

Courtland Sutton anytime TD scorer (+175) + RJ Harvey anytime TD scorer (+175) + Bo Nix anytime TD scorer (+310)

Parlay Payout: Wager $100 to win $2,179

We chose this same-game parlay around the Denver Broncos to win comfortably at home. Courtland Sutton is the go-to receiver for the team and has recorded 2 TDs in the last three games, with significant increase in touches over the last four games with 10 or more receptions in each game.

Similarly, rookie RB RJ Harvey has been utilized as a red-zone threat this season with 3 rushing TDs and a receiving TD in the last four games. With the Chargers missing majority of the players both on the offensive and the defensive side of the field, this is a safe bet.

Bo Nix is a threat to score at any time as he’s recorded 6 passing TDs in his last three games, and he’s also contributed a rushing touchdowns going against the Chiefs last week. With the Chargers’ passing defense missing majority of the players from their lineup, this is a great bet.

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Same-Game Parlay 2

Courtland Sutton 50+ Yards receiving yards (-154)+ Bo Nix under 1.5 passing TDs (-118)+ Trey Lance under 0.5 passing touchdowns (-116)

Courtland Sutton has had an amazing string of games in the last 5 weeks, posting beyond 50+ yards in 4 of the five games. Part of that is the increased volume of targets that he’s been getting with 10 or more in the last four games. He also recorded a 113 yards performance against the Packers, which makes us believe that 50+ yards in this game is probable.

Bo Nix has only recorded 2 or more passing TDs in 6 of 17 games this season and is not exactly an explosive offensive player. The Broncos are more likely to jump out to an early lead and control the clock in this game, making it likely that Nix stays under 1.5 TDs. The Chargers rank 7th in the league this season in scoring defense allowing 20.1 points per game, making this a great bet.

Trey Lance under 0.5 passing touchdowns is likely as he is making his first start this season and has not recorded a touchdown since the 2021 season. The Broncos have one of the best defensive units in the league, and have little to no flaws in their defense, which could likely give Lance a tough day at the office, making this a safe bet.

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Broncos vs Chargers Odds

Looking at the spread and the moneyline, the Broncos are the overwhelming favorites to beat the Chargers, as per BetMGM.

TeamsSpreadTotalMoneyline
Chargers16.5 (-110)36.5 (-118)+900
Broncos16.5 (-118)36.5 (-110)-1600
Odds updated: Sunday, January 4, 2026. Lines may move throughout the day. 

Matchup Analysis

Offense vs Defense breakdown for the Broncos vs Chargers

The Denver Broncos (13-3) have clinched the AFC West but are pushing for the No.1 seed. At home under Sean Payton, they average 44 PPG, led by QB Bo Nix (3,790 yards, 25 TDs). While their defense tops the NFL with 64 sacks and rank 3rd overall, with 282.1 defensive yards average and 29 TDs allowed (league best).

The Los Angeles Chargers (11-5) already a wild card team, will rest QB Justin Herbert and key starters like Keenan Allen, Khalil Mack, and Derwin James. Backup Trey Lance gets his first start as a Charger, facing Denver’s dominant pass rush behind a depleted offensive line.

Trends to Know for Denver Broncos vs Los Angeles Chargers

Here are a few betting trends to keep in mind for Denver Broncos vs Los Angeles Chargers.

  • The Chargers are resting their starters in this game.
  • The Broncos can secure the No.1 seed with a win.
  • Denver is 4-4 against the spread and 7-1 overall, at home.
  • Denver has covered the spread in a game six times this season (6-10-0).

How to Watch Broncos vs Chargers Today

  • Date: January 4, 2025
  • Time: 4: 25 PM EST
  • TV: CBS
  • Streaming: FUBOTV

Injuries and Weather Report

Injury Report for Los Angeles Chargers

PlayerPostionInjuryStatus
Keenan AllenWRNIR – Rest(-)
Bradley BozemanCConcussionQuestionable
Derius DavisWRAnkle(-)
Omarion HamptonRBAnkleOut
Hassan HaskinsRBConcussionQuestionable
Justin HerbertQBLeft Hand/NIR – Rest(-)
Derwin JamesSNIR – Rest(-)
Khalil MackOLBNIR – Rest(-)
R.J. MickensSShoulderQuestionable
Elijah MoldenDBHamstringDoubtful
Nikko ReedCBHamstringOut
Jamaree SalyerOLHamstringDoubtful
Benjamin St-JusteCBShoulderQuestionable
Tuli TuipulotuOLBNIR- Rest(-)
Kimani VidalRBNeckQuestionable

Injury Report for Los Angeles Chargers

PlayerPostionInjuryStatus
Nate AdkinsTEKnee(-)
Pat BryantWRConcussion(-)
Ben PowersGBiceps(-)
Karene ReidLBHamstringOut
John Franklin-MyersDEHipQuestionable
Dre GreenlawLBHamstringOut

Weather for the Broncos vs Chargers Game

The weather forcast predicts a partially cloudy sky with temperatures ranging from the upper 50s to mid 60s Fahrenheit. The impact on the game should be minimal with 0% chance for rain.

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FAQs

Who is favored to win between the Broncos vs Chargers?
The Broncos are 16.5-point favorites to win the matchup against Chargers.

What is the over/under total for the game?
The over/under for total points is set at 36.5.

Where will the Broncos vs Chargers match take place?
The Broncos vs Chargers set will be played at Empower Field at Mile High, Denver, home of the Broncos.

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I cover the National Football League and things cannot get better than that. I always dreamed to play football or basketball professionally since I’m built like a Running Back. But now that I can’t, since I’m technically in the “Unc” age, I thought why not pick a career in sports industry? So here I am, doing what I love, and hoping that the Commanders win the Super Bowl. I give love to players when it’s due, but can be critical about their performances at the same time. Enough about me, now let my articles do all the talking. 

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