Image Credit: Eric Canha-Imagn Images

Boston Celtics vs Philadelphia 76ers Injury Report and Predicted Starting Lineups- What are Injury Updates for Jayson Tatum, Joel Embiid, Paul George and More for their First Regular Season Game?

The 76ers visit TD Garden to lock horns with the Boston Celtics on Wednesday.

Image Credit: Eric Canha-Imagn Images

The Boston Celtics will be up against the Philadelphia 76ers for their regular-season opener on Wednesday, October 22, 2025. The Celtics finished the NBA 2024-25 campaign with a 61-21 win-loss record in the East. While they were hoping to repeat their previous season’s heroics, Jayson Tatum’s injury shattered their dreams.

Setting the tone. pic.twitter.com/U9Tl6ppPXC
— Boston Celtics (@celtics) October 21, 2025

The Celtics superstar suffered an Achilles injury in the Eastern Conference semifinal loss to the New York Knicks. He is expected to miss most, if not all, of this season. Apart from him, they parted ways with Al Horford, Luke Kornet, and Kristaps Porzingis during the offseason. However, there are familiar names in the roster including Derrick White, Sam Hauser, and Jordan Walsh.

The Philadelphia 76ers, on the other hand, had a miserable 2024-25 season with a 24-58 win-loss record. However, they will aim to wipe the slate clean and move forward hoping for a better campaign. They have an impactful roster featuring the trio of Joel Embiid, Paul George and Tyrese Maxey.

But they need to be in the best of health throughout the season as the Sixers aim for contention. If they stay healthy and the new additions that they made play their roles, there is a chance for the 76ers to break through in the East.

As both teams aim for a favorable start to the 2025-26 campaign, let’s go through their injury reports as well as expected starting lineups for the Wednesday-night game.

Boston Celtics Injury Updates for Game Against Philadelphia 76ers

PLAYER	POSITION	INJURY	STATUS
Jaylen Brown	SF	Hamstring	QUESTIONABLE
Jayson Tatum	PF	Achilles	OUT

The Celtics have listed Jaylen Brown as questionable for their first game of the 2025-26 season on Wednesday. Brown suffered a hamstring injury during a preseason game against the Toronto Raptors and participated in two full practices. Jayson Tatum, on the other hand, will likely be out of action for most, if not all, of the current season.

Philadelphia 76ers Injury Report for Game Against Boston Celtics

PLAYER	POSITION	INJURY	STATUS
Paul George	SF	Knee	Out
Trendon Watford	PF	Hamstring	Out
Jared McCain	SG	Thumb	Out

Philadelphia will be without veteran forward Paul George, who is recovering from arthroscopic knee surgery performed during the offseason. He didn’t play in any preseason games but participated fully in practice Sunday. McCain and Watford will be out with right thumb surgery recovery and hamstring tightness, respectively.

Injur report for tomorrow in Boston:

OUT: Trendon Watford (left hamstring tightness), Paul George (left knee injury recovery), Jared McCain (right thumb surgery recovery)

Joel Embiid is NOT listed #Sixers
— Ky Carlin (@Ky_Carlin) October 21, 2025

Boston Celtics vs Philadelphia 76ers Expected Starting Lineups:

Boston Celtics: Payton Pritchard, Derrick White, Jaylen Brown*, Chris Boucher, Neemias Queta

Philadelphia 76ers: Tyrese Maxey, VJ Edgecombe, Kelly Oubre Jr, Adem Bona, Joel Embiid.

Boston Celtics

Philadelphia 76ers

Garima Ranawat

Garima is a sports writer with around two years of experience in Indian sports and a newfound interest in the NBA. Inspired by the leadership of cricketing legend MS Dhoni, she wishes to bring in newer perspectives to the NBA fanatics with her writing.