Buffalo Bills vs Tampa Bay Buccaneers Predictions, Odds, and Best Bets for Week 11 2025-26 NFL Season

The Buffalo Bills host the Tampa Bay Buccaneers for Week 11’s exciting AFC vs NFC powerhouses facing off. The Bills started off their season extremely hot and has pulled off some very impressive wins against playoff contending teams like the Kansas City Chiefs. However, they have dropped some very winnable games, especially when their offense is not on point . They are very reliant on their offense and their defense can be vulnerable, losing to the Miami Dolphins last week. The Bills are second in the AFC East and their playoff hopes remains to be a question for now.

Meanwhile, the Buccaneers come into this matchup losing to the New England Patriots. They are 6-3 for the season and even with Baker Mayfield playing at an MVP level, their various injuries that they’ve sustained, has slowed them down. Going against the Bills will be another difficult matchup for them, but they still lead the NFC South division providing hope for their playoff chances.

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Recommended Bets and Updated Odds

Recommended Bets	Fanduel	BetMGM
Baker Mayfield over 0.5 interceptions	-128	+100
Rachaad White over 43.5 rushing yards	-114	-115
James Cooks anytime TD scorer	-160	-190

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Analysis and Rationale

Baker Mayfield may throw over 1.5 interceptions in this game, as Buffalo’s defense, while vulnerable at times, ranks second in pass defense. Mayfield this season has been highly efficient throwing only two interceptions this season, however, his two INTs came against two playoff caliber teams. If the Bills jump ahead and gain a lead, Mayfield may go into panic mode and try to make things happen, leading to risky picks and eventually an interception.

Rachaad White should be able get 43.5 rushing yards or more in this game as the Bills rank 28th against the run, making them one of the worst rush defense teams in the NFL. 141.4 rushing yards is what the Bills allow on average and we expect Tampa to exploit this glaring hole in their defense using White, crossing 43.5 yards.

James Cook is threat to score at any time as he is the Bills’ best offensive weapon and is heavily utilized, whether it’s rushing or catching a reception and from Josh Allen. In this game, if the Bills get to the Red Zone, we expect them to go to Cook to score a TD or two, as the Tampa has glaring holes in their red zone defense ranking 22nd.

Bills vs Buccaneers Prediction

We expect the Buffalo Bills to take down the Tampa Bay Buccaneers, because of the amount of offensive talent the Bills have, and the injuries that Tampa’s dealing with including Chris Godwin Jr and Bucky Irving who’s out for the game. The Buccaneers are short handed and stopping the Bills from scoring the football, is a tall task. Expect the game to be close, but the Bills to pull away, but not without the Bucs putting up a fight.

Prediction: Bills win the game 27-24

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Week 11 Bills vs Buccaneers Spread and Betting Odds

Looking at the spread and the moneyline, the Bills are the favorites to walk away with a victory over the Buccaneers, as per BetMGM

Teams	Spread	Total Points	Moneyline
Buccaneers	+5.5 (-110)	47 (-110)	+200
Bills	-5.5 (-110)	47 (-110)	-250

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Bills vs Buccaneers Betting Odds

Here are some of the best player bets and over/under odds for the Buffalo Bills and the Tampa Bay Buccaneers, as per BetMGM.

Buffalo Bills Over/Under Odds

Listed below are some over/under odds for the Buffalo Bills, as per BetMGM.

Over/Under Odds	Over	Under
Josh Allen passing yards	220.5 (-115)	220.5 (-115)
James Cook rushing yards	80.5 (-110)	80.5 (-118)
Khalil Shakir receiving yards	45.5 (+100)	45.5 (-135)

Buffalo Bills Best Player Bets

Here are some of the best player bets for the Buffalo Bills, as per BetMGM.

James Cook anytime TD scorer: -190
Josh Allen anytime TD scorer: -125
Josh Allen under 1.5 passing TDs: -150

Tampa Bay Buccaneers Over/Under Odds

Listed below are over/under odds for the Tampa Bay Buccaneers, as per BetMGM.

Over/Under Odds	Over	Under
Baker Mayfield passing yards	206.5 (-115)	206.5 (-115)
Rachaad White rushing yards	43.5 (-115)	43.5 (-115)
Emeka Egbuka receiving yards	59.5 (-110)	59.5 (-118)

Tampa Bay Buccaneers Best Player Bets

Here are some of the best player bets for the Tampa Bay Buccaneers, as per BetMGM

Rachaad White anytime TD scorer: -150
Emeka Egbuka anytime TD scorer: +150
Baker Mayfield under 1.5 passing TDs: -155

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(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

FAQs

Who is favored to win between the Bills vs Buccaneers?
The Bills are 5.5-point favorites to win the matchup against Buccaneers.

What is the over/under total for the game?
The over/under for total points is set at 47.

What is the predicted score for the Bills vs Buccaneers game?
We expect the Bills to take down the Buccaneers in a close victory, and the Final score to be 27-24.

Eric Divakaran

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I cover the National Football League and things cannot get better than that. I always dreamed to play football or basketball professionally since I’m built like a Running Back. But now that I can’t, since I’m technically in the “Unc” age, I thought why not pick a career in sports industry? So here I am, doing what I love, and hoping that the Commanders win the Super Bowl. I give love to players when it’s due, but can be critical about their performances at the same time. Enough about me, now let my articles do all the talking.