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Atletico Madrid vs Real Madrid Preview, Betting Odds and Predictions – 27/09/2025

Abhinav Goel
Soccer / La Liga
27/09/2025 – 15:15
Atletico Madrid
VS
15:15
27/09/2025
Real Madrid
Odds updated on September 25, 2025 at 9:34 pm

The Madrid derby takes centre stage on Saturday as Real Madrid look to extend their perfect start to the 2025-26 La Liga season. Los Blancos have been flawless so far, collecting 18 points from their first six games to sit five clear at the top of the table. Meanwhile, Atletico Madrid find themselves under pressure in ninth position with just nine points to their name.

Atletico head into the clash on the back of a dramatic 3-2 win over Rayo Vallecano, where Julian Alvarez’s hat-trick rescued Diego Simeone’s side. That result lifted them back into the top half of the standings, but inconsistency has been a issue this season with only two wins from their opening six fixtures.

Atletico Madrid vs Real Madrid Best Bets

BetsMoneylineMoneyline
Full Time ResultAtletico Madrid: +185, Real Madrid: +135Draw: +250
Draw No BetAtletico Madrid: +105Real Madrid: -145
Total GoalsOver 2.5: -150Under 2.5: +110
Atletico Madrid to Win and Both Teams to ScoreYes: +360No: +425
Real Madrid to Win and Both Teams to ScoreYes: +290No: +340

(Odds via BetMGM)

Atletico Madrid vs Real Madrid Preview

Defensive solidity has long been Atletico’s trademark, yet they have looked vulnerable at the back this season. Simeone must fix his team’s quickly, with Kylian Mbappe and Vinicius Junior arriving in devastating form for Real. Keeping Madrid’s frontline quiet will be a huge test for Atletico’s back line that has yet to convince.

However, head-to-head history will offer encouragement for the home side. Each of the last three league derbies has finished 1-1, while Atletico are unbeaten in their last five La Liga meetings with Real since September 2022. The Wanda Metropolitano has often been a tough place for their city rivals, with Real managing just two league wins away to Atletico since November 2016.

Also Read: Brentford vs Manchester United Preview, Betting Odds and Predictions – 27/09/25

Atletico Madrid vs Real Madrid Over/Under Predictions

Over 2.5 Goals @ -150 as per BetMGM

Goals look likely in this Madrid derby given the recent form of both sides. Atletico’s matches have seen plenty of action, including a thrilling 3-2 win over Rayo Vallecano and a narrow 3-2 defeat to Liverpool in the Champions League. Meanwhile, Real Madrid are in devastating attacking form, scoring at least twice in each of their last four games.

With Atletico conceding six goals in their last four and Real averaging over two goals per game, the conditions are set for a high-scoring derby. Over 2.5 goals looks like the logical play here.

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Atletico Madrid vs Real Madrid Player Picks

Kylian Mbappe to score anytime @ +115 as per BetMGM:

French star Kylian Mbappe has been in electrifying form this season and backing him to score anytime at +115 looks like a strong play. Mbappe has already struck seven goals in six La Liga matches this campaign. His pace, movement, and finishing touch make him Real Madrid’s most consistent attacking threat. Given his current hot streak, it would be no surprise to see him on the scoresheet again in the Madrid derby.

Also Read: Ousmane Dembele Crowned Men’s Ballon d’Or 2025 Winner

Atletico Madrid vs Real Madrid Final Scoreline Prediction

For Xabi Alonso’s Real Madrid, momentum is firmly with them. A 4-1 victory over Levante last time out maintained their 100% record in both La Liga and Europe. Eith Mbappe leading the charge and Barcelona chasing, Los Blancos know three points in the derby would strengthen their grip at the summit. As a result, Real Madrid could edge this contestt narrowly.

Final Prediction: Atletico Madrid 1-2 Real Madrid

Bettors can explore a variety of betting options on BetMGM, including full-time results, over/under goals, and player props for this clash.

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I am a soccer writer at The PlayOffs, covering everything from match analysis to transfer buzz and tactical deep dives. Ever since I was a kid, soccer has been more than just a sport to me—it’s been an obsession. Playing and watching the game from a young age fueled my passion, eventually leading me into the world of sports media and betting. Now, I get to analyze the sport I love and bring the latest updates to fans worldwide.

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