Ajax vs Inter Milan Preview, Betting Odds and Predictions – 17/09/2025

Four-time European champions Ajax launch their Champions League campaign on Wednesday when they host last season’s runners-up Inter Milan at the Johan Cruyff Arena. The Dutch giants come into the clash unbeaten so far this season. On the other hand, Inter arrive in Amsterdam on the back of successive defeats.

Under new manager John Heitinga, Ajax are yet to taste defeat this season, winning all three of their home fixtures. Regardless of their domestic showings, concerns remain over whether they can perform against Europe’s elite. With just one progression beyond the group stage in their last four attempts since the famous 2019 semi-final run, the pressure is on Ajax to make a statement.

.@SamuelEtoo 🆚🇳🇱⚽#ForzaInter #UCL | pic.twitter.com/s0j3MU7iBy
— Inter ⭐⭐ (@Inter) September 16, 2025

Ajax vs Inter Milan Best Bets

Bets	Moneyline	Moneyline
Full Time Result	Ajax: +290, Inter Milan: -125	Draw: +275
Draw No Bet	Ajax: +190	Inter Milan: -275
Total Goals	Over 2.5: -155	Under 2.5: +110
Ajax to Win and Both Teams to Score	Yes: +525	No: +625
Inter Milan to Win and Both Teams to Score	Yes: +225	No: +230

(Odds via BetMGM)

Ajax vs Inter Milan Preview

Inter Milan suffered disappointment on multiple fronts last season. Missing out on the Scudetto to Napoli was damaging enough, but their humiliation in the Champions League final was even worse. After sweeping past Barcelona in the semi-final and recording 10 wins in the competition, they were destroyed 5-0 by Paris Saint-Germain in a one-sided affair.

The Nerazzurri turned to Cristian Chivu, the former Ajax and Inter defender. Chivu started brightly with a dominant 5-0 win over Torino. But Inter’s form has dipped since, suffering a shock defeat to Udinese and then losing an enthralling Derby d’Italia 4-3 to Juventus.

Also read: Atletico Madrid Suffer Double Injury Scare Ahead of Champions League Clash With Liverpool

Now, Chivu must steady the ship and rally his squad for a tough European campaign. Inter have reached two Champions League finals in three seasons and remain a formidable force, but they will need to show resilience in Amsterdam against a resurgent Ajax.

Ajax vs Inter Milan Over/Under Predictions

Ajax vs Inter Milan Over 2.5 Goals @ -155 as per BetMGM

Inter’s league games have been wide-open: 5–0 vs Torino, 1–2 vs Udinese and 3–4 at Juventus. Ajax are scoring consistently too. With Inter’s back line conceding 6 in their last two and Ajax dangerous at home, this looks like a game where both sides will score and 3+ goals is the likeliest script.

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Ajax vs Inter Milan Player Picks

Lautaro Martinez to score anytime @ +125 as per BetMGM:

Inter captain Lautaro Martínez has opened the new campaign at a slower pace by his usual high standards. He has only scored once in three Serie A outings so far. However, the Argentine remains a proven force in Europe, having struck nine times in last season’s Champions League run to the final. With the responsibility of leading Inter’s line, Martinez is well-positioned to get back on track with a goal.

Also Read: Alexis Max Allister Injury Update: What Did Liverpool Boss Arne Slot Say?

Ajax vs Inter Milan Final Scoreline Prediction

Ajax’s attack is capable of troubling Inter, especially with the hosts unbeaten at home so far this season. However, Cristian Chivu’s Inter Milan will be eager to respond after their recent domestic setbacks. Inter’s firepower up front and superior Champions League experience should give them the edge in Amsterdam.

Final Prediction: Ajax 1-2 Inter Milan

Bettors can explore a variety of betting options on BetMGM, including full-time results, over/under goals, and player props for this Champions League clash.

Abhinav Goel

soccer

I am a soccer writer at The PlayOffs, covering everything from match analysis to transfer buzz and tactical deep dives. Ever since I was a kid, soccer has been more than just a sport to me—it’s been an obsession. Playing and watching the game from a young age fueled my passion, eventually leading me into the world of sports media and betting. Now, I get to analyze the sport I love and bring the latest updates to fans worldwide.