New Orleans Saints vs Buffalo Bills Preview, Betting Odds, and Predictions – NFL 2025-26 Season Week 4

Its the undefeated Bills against the winless Saints in this week 4 game on Sunday!

New Orleans Saints vs Buffalo Bills Preview, Betting Odds, and Predictions for the 2025-26 NFL Season Week 4

The Bills Mafia is set to make some noise in this week 4 Saints vs Bills matchup at Highmark Stadium in Western New York. Buffalo is cruising along well with a perfect 3-0 start to its season, whereas the Saints are still searching for their first win with a 0-3 record.

Recommended bets and updated odds

Recommended Bets	FanDuel	BetMGM
Josh Allen over 1.5 passing touchdowns	-166	-167
Bills cover 15.5-point spread	-110	-110
Total Points Under 48.5	-188	-122

Analysis and Rationale

Josh Allen has 5 passing touchdowns in his first three games. Moreover, the Saints’ defense has allowed 7 passing touchdowns in three games, which makes this bet worth considering.

Buffalo’s offense has put up plenty of points in all three of its games so far. While the defense has conceded many points to the Ravens, they limited the Jets to just 10. The Saints’ offense has struggled quite a bit to score.

The total points under 48.5 looks like a good bet based on the fact that the Saints’ offense has struggled to put points on the board even against the likes of the Arizona Cardinals. Going up against the Bills’ defense may prove even tougher. Buffalo has scored freely in its three games, but even then, the over seems a bit out of reach in this game.

#Bills Week 4 Uniform Combo:

Blue on White vs the #Saints!

🔵⚪️🔵⚪️#BuiltInBuffalo | #GoBills | #BillsMafia pic.twitter.com/1nPeRiGmma
— Built in Buffalo (@BuiltInBuffalo_) September 24, 2025

New Orleans Saints vs Buffalo Bills Preview

The New Orleans Saints are coming into their week 4 matchup without a win. Their last game was against the Seattle Seahawks, in which they lost by a big margin (44-13). Offensively, the Saints have struggled to score points, while the defense was decent in the first couple of weeks.

The Buffalo Bills, on the other hand, are enjoying an excellent start to their season with important wins against the AFC juggernaut, the Baltimore Ravens, and divisional opponents, the Jets and Dolphins.

New Orleans Saints Best Bets – Over/Under and Player Bets

Below are some of the best player bets for the New Orleans Saints as sourced from FanDuel.

New Orleans Saints Over/Under Bets

Over/ Under Bets	Over	Under
Spencer Rattler Passing Yards	200.5 (-114)	200.5 (-114)
Alvin Kamara Rushing Yards	50.5 (-114)	50.5 (-114)
Chris Olave Receiving Yards	58.5 (-114)	58.5 (-114)

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New Orleans Saints Best Player Bets

Below are some of the best player bets for the New Orleans Saints as sourced from FanDuel.

Spencer Rattler Interception: -168
Alvin Kamara 60+ Rushing Yards: +144
Rashid Shaheed 40+ Receiving Yards: +104

prep ✔️ pic.twitter.com/1eSfEbxdIH
— New Orleans Saints (@Saints) September 25, 2025

Buffalo Bills Best Bets – Over/Under and Player Bets

Here is a look at the over/under and player bets for the Buffalo Bills as per FanDuel.

Buffalo Bills Over/Under Bets

Over/ Under Bets	Over	Under
Josh Allen Passing Yards	216.5 (-114)	216.5 (-114)
James Cook Rushing Yards	74.5 (-114)	74.5 (-114)
Keon Coleman Total Receptions	3.5 (-102)	3.5 (-130)

Buffalo Bills Best Player Bets

Below are some of the best player bets for the Buffalo Bills as sourced from FanDuel.

James Cook Anytime Touchdown Scorer: – 210
Dalton Kincaid 4+ Receptions: -114
James Cook 70+ Yards: -144

𝗗𝗜𝗗 𝗬𝗢𝗨 𝗞𝗡𝗢𝗪?: The #Bills defense is giving up the 2nd fewest pass yards per game.

131.3 yards allowed per game is second to the #Falcons 131.0 yards per game.#BuiltInBuffalo | #GoBills | #BillsMafia pic.twitter.com/eqL13fc7BF
— Built in Buffalo (@BuiltInBuffalo_) September 25, 2025

Week 4 Saints vs Bills Predictions

On paper, this is one of the biggest mismatches this season. The Bills are firing on all cylinders, and reigning NFL MVP Josh Allen has continued to show why he is a player who needs to be taken seriously. Moreover, James Cook is providing support from the backfield that has eased Allen’s workload.

The Saints are currently in a rebuild mode. Languishing in last place in the NFC South, New Orleans just doesn’t have the capacity to go toe-to-toe with the heavyweights of the league, such as the Bills.

Our Prediction: Bills to win and cover the spread.

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Saints vs Bills Betting Odds and Spread

The moneyline and spread show the Buffalo Bills are massive favorites in this matchup against the New Orleans Saints, as sourced from FanDuel.

	Moneyline	Spread	Total Points
New Orleans Saints	+870	+15.5 (-110)	O 48.5 (-104)
Buffalo Bills	-1500	-15.5 (-110)	U 48.5 (-118)

The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

FAQs

What is the over/under for total points for the Saints vs Bills game?

The over/under for total points in the Saints vs Bills game is set at 48.5.

What is the point spread for the Saints vs Bills game on Sunday?

The Bills come into the game as massive 15.5-point favorites over the Saints.

What is the moneyline for the Saints vs Bills game in week 2?

The Bills are the favorites with a moneyline of -1500, while the Saints are the underdogs at +870.

Mandatory Credit: Gregory Fisher-Imagn Images

Devavrat Kulkarni

nfl

I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!