New York Giants vs Kansas City Chiefs Preview, Betting Odds, and Predictions – NFL 2025-26 Season Week 3

The Kansas City Chiefs are travelling on the road to face the New York Giants for this interconference Week 3 clash. Both the Chiefs and the Giants are mightily struggling so far in the 2025-26 campaign, with no wins to show for either side. The Chiefs are currently missing some of their key players going into this game, whereas the Giants are coming off a heartbreaking OT loss.

With both teams desperate to get a win, the game will come down to who wants the win more, at the end of the day. Travis Kelce and Patrick Mahomes are set to face Russell Wilson and Malik Nabers.

Recommended Bets	FanDuel	BetMGM
Travis Kelce to score a TD	+120	+140
Patrick Mahomes Under 34.5 Passing Attempts	-120	-140
Total TDs Over 4.5	-158	-160

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Rationale and Analysis

Travis Kelce remains a top TD threat in Week 3 vs the Giants. He posted 108 yards and a TD across Weeks 1 and 2, showing that he can still be efficient, and productive on red zone usage. With Mahomes targeting him in key moments and the Giants vulnerable to tight ends, Kelce’s route precision and mismatch ability make him a strong candidate to score vs. the Giants.

Patrick Mahomes Under 34.5 attempts is viable vs. the Giants. Kansas City may lean run-heavy exploit New York’s defensive front and control tempo. Mahomes had 30 and 33 attempts in Weeks 1 and 2, but that was because of the extremely tight defense that the Eagles and the Chargers played. If the Chiefs build an early lead or dominate possession, expect fewer dropbacks and a balanced offensive approach.

Over 4.5 total touchdowns is a strong bet for the Giants vs Chiefs as Kansas’s offense, led by Mahomes, consistently generate multiple scores. The Giants, despite inconsistency, can contribute explosive plays or garbage-time production, like we saw them do last game against the Cowboys. Both defenses have shown vulnerabilities, and with playmakers on both sides, expect enough scoring chances to push this game past the 4.5 TD mark.

New York Giants vs Kansas City Chiefs Preview

The Chiefs (0-2) host the Giants (0-2) in a Week 3 matchup featuring contrasting offensive styles. Kansas City leans on Mahomes’ efficiency and Kelce, while New York have their own weapons with Russell Wilson and Malik Nabers, who can have explosive games.

While the Chiefs still play great defense, this is the first time that Mahomes has lost 3 straight games. They are missing two of their most essential playmakers in Rashee Rice and Xavier Worthy, which has added to the Chiefs’ struggles.

Coach Daboll previews Sunday's matchup against the Chiefs pic.twitter.com/UqbNOuXSXo
— New York Giants (@Giants) September 20, 2025

Meanwhile, the Giants are coming off a heartbreaking loss to the Cowboys in OT. While they managed to tie the game initially and force overtime, they just could not stop the Cowboys in the very end.

With both these teams desperate for a win, watchout for explosive plays to take place in this game.

New York Giants Best Bets – Over/Under and Player Bets

Here are over/under and the best player bets for the New York Giants, as per BetMGM

Over/Under Bets	Over	Under
Russell Wilson Passing Yards	225.5 (-115)	225.5 (-115)
Malik Nabers Receiving Yards	77.5 (-118)	77.5 (-110)
Cam Skattebo	35.5 (-110)	35.5 (-118)

New York Giants Best Player Bets

Below are some of the best player bets for the New York Giants, as per BetMGM

Malik Nabers Anytime TD Scorer: +155
Russell Wilson over 37.5 yards longest pass completion: -115
Graham Gano Under 1.5 Field Goals: -165

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Kansas City Chiefs Best Bets – Over/Under and Player Bets

Here are some of the best player bets for the Kansas City Chiefs, according to BetMGM

Over/Under Bets	Over	Under
Patrick Mahomes Passing Yards	231.5 (-115)	231.5 (-118)
Marquise Brown Receiving Yards	55.5 (-115)	55.5 (-115)
Isiah Pacheco	41.5 (-115)	41.5 (-115)

Kansas City Chiefs Best Player Bets

Below are some of the best player bets for the Kansas City Chiefs, according to BetMGM

Kareem Hunt Rushing Attempts Under 9.5: -135
Patrick Mahomes Passing Attempts Under 34.5: -140
Patrick Mahomes Over 1.5 Passing TDs: -145

Giants vs Chiefs Prediction for Week 3 of the 2025-26 NFL Season

Kansas City should be able to defeat New York in Week 3. Even without a pass-heavy gameplan, even though Mahomes can always fall back to passing if things don’t go accordingly. While the Chiefs have had their offensive struggles, with players unable to catch passes from their QB leading to interceptions, they are simply the far superior team with championship DNA in them.

Prediction: Chiefs win the game

Week 3 in NYC. pic.twitter.com/BxZMqLt9h7
— Kansas City Chiefs (@Chiefs) September 19, 2025

Giants vs Chiefs Spread and Betting Odds

The spread and the moneyline show that the Chiefs are the clear favorites to win this matchup against the Giants, according to BetMGM.

Teams	Spread	Total Points	Moneyline
Chiefs	-6 (-110)	45 (-110)	-295
Giants	+6 (-110)	45 (-110)	+240

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(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

FAQs

Who is favored in the Giants vs Chiefs game?
Chiefs are 6-point favorites with a -295 moneyline.

What is the over/under total for the game?
Total points line is set at 45.

What is the predicted outcome of the game?
We predict the Chiefs to defeat the Giants.

Eric Divakaran

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I cover the National Football League and things cannot get better than that. I always dreamed to play football or basketball professionally since I’m built like a Running Back. But now that I can’t, since I’m technically in the “Unc” age, I thought why not pick a career in sports industry? So here I am, doing what I love, and hoping that the Commanders win the Super Bowl. I give love to players when it’s due, but can be critical about their performances at the same time. Enough about me, now let my articles do all the talking.