Inter Milan vs Sassuolo Preview, Betting Odds and Predictions – 21/09/2025

Inter Milan return to Serie A action on Sunday with the aim of building on their Champions League success in midweek. Cristian Chivu’s men travel back from Amsterdam in high spirits after a 2-0 victory over Ajax. However, Inter’s form in Serie A has been patchy.

Having returned to Serie A as Serie B champions, Sassuolo endured a tough start with defeats to Napoli and Cremonese. Yet they announced themselves properly last weekend, shocking Lazio with a 1-0 victory courtesy of Alieu Fadera’s late goal. It was a result that underlined both their spirit and manager Fabio Grosso’s tactical knowledge.

This match really was unforgettable 🤩#ForzaInter #InterSassuolo pic.twitter.com/Iirb0QJVWt
— Inter ⭐⭐ (@Inter_en) September 20, 2025

Inter Milan vs Sassuolo Best Bets

Bets	Moneyline	Moneyline
Full Time Result	Inter Milan: -350, Sassuolo: +950	Draw: +475
Draw No Bet	Inter Milan: -1400	Sassuolo: +675
Total Goals	Over 3.5: +130	Under 3.5: -185
Inter Milan to Win and Both Teams to Score	Yes: +180	No: +105
Sassuolo to Win and Both Teams to Score	Yes: +1450	No: +1400

(Odds via BetMGM)

Inter Milan vs Sassuolo Preview

With Napoli and Juventus setting the pace at the top, Inter cannot afford another slip at this stage of the season. Sassuolo, however, are a side that Inter have often struggled against. The Neroverdi have beaten Inter 10 times in their 22 Serie A meetings and have taken points from seven of their last nine visits to San Siro.

Inter will have to be on guard despite the gulf in quality between the two squads. The home side remain favourites, but with Sassuolo growing in confidence and carrying a history of strong results at San Siro, this clash may be more competitive than it appears on paper. Chivu’s men know only a win will do as they look to steady their league campaign and keep the pressure on their rivals at the top.

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Inter Milan vs Sassuolo Over/Under Predictions

Inter Milan vs Sassuolo Under 3.5 Goals @ -185 as per BetMGM

Inter tightened up their defence in the 2-0 win over Ajax in midweek. Expect a similar game control from Chivu after the Champions League trip. Meanwhile, three of Sassuolo’s last four games have finished below 3.5 goals (1-0 vs Lazio, 0-2 vs Napoli, 1-0 vs Catanzaro). As a promoted side, Grosso’s team has leaned on compact shapes away from home. With Inter likely to dominate territory rather, Under 3.5 goals is a sensible play here.

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Inter Milan vs Sassuolo Player Picks

Lautaro Martinez to score anytime @ +125 as per BetMGM:

Inter captain Lautaro Martinez has opened the new campaign at a slower pace by his usual high standards. He has only scored once in three Serie A outings so far. However, the Argentine remains a proven force in Serie A. With the responsibility of leading Inter’s line, Martinez is well-positioned to get back on track with a goal.

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Inter Milan vs Sassuolo Final Scoreline Prediction

Inter remain a side in transition under new management, and their performances have been unpredictable this season. Sassuolo are capable of creating problems, but Inter’s greater firepower and home advantage make them favourites to grind out a narrow victory.

Final Prediction: Inter Milan 2-0 Sassuolo

Bettors can explore a variety of betting options on BetMGM, including full-time results, over/under goals, and player props for this match.

Abhinav Goel

soccer

I am a soccer writer at The PlayOffs, covering everything from match analysis to transfer buzz and tactical deep dives. Ever since I was a kid, soccer has been more than just a sport to me—it’s been an obsession. Playing and watching the game from a young age fueled my passion, eventually leading me into the world of sports media and betting. Now, I get to analyze the sport I love and bring the latest updates to fans worldwide.