Aug 26, 2025; Flushing, NY, USA; Jannik Sinner (ITA) hits to Vit Kopriva (CZE) (not pictured) on day three of the 2025 U.S. Open tennis tournament at the USTA Billie Jean King National Tennis Center.

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Jannik Sinner vs. Alexei Popyrin Head-to-Head, Prediction and Betting Odds for US Open 2025 Round-2

The World No. 1 has an uphill battle to overcome.

Aug 26, 2025; Flushing, NY, USA; Jannik Sinner (ITA) hits to Vit Kopriva (CZE) (not pictured) on day three of the 2025 U.S. Open tennis tournament at the USTA Billie Jean King National Tennis Center.

World No. 1 Jannik Sinner will be tasked with a brutally harsh test in the early stages of his US Open 2025 campaign. The four-time Grand Slam champion is set to take on giant slayer and former Top-20 star Alexei Popyrin in the Round of 64 on Thursday. The Australian conquered the Novak Djokovic challenge at this event twelve months ago, and will be on a mission to deny the top seed his third major of the year. With the help of BetMGM, we look to break down the stats and odds for this clash.

Jannik Sinner vs Alexei Popyrin Match Preview

Owing to his three month suspension, Jannik Sinner has featured in just six tournaments prior to the US Open. He has reached the final in five out of these six events – winning two trophies in the bargain. In the aftermath of his grand Wimbledon success, the top seed reached the Cincinnati Open final, where he had to retire midway vs Alcaraz. Sinner has served 221 aces this year, culminating in 79% points won on first serve and 69% break points saved in 2025. He defeated Kopriva 6-1 6-1 6-2 in Round-1.

Feels great to be back here 👏🏻 Happy with today’s performance and grateful to be healthy again. Thank you all for the support ❤️ @usopen pic.twitter.com/Lo8oIMbGqo
— Jannik Sinner (@janniksin) August 26, 2025

World No. 36 Alexei Popyrin had an abysmal 2-7 run during the hard court swing to start the season. However, two quarterfinal outings on clay helped him reach the Roland Garros Round of 16. His next burst of good results came at the Canadian Open, where he reached another quarterfinal. At last year’s US Open, Popyrin beat Djokovic en route to his career-best pre-quarterfinal finish at a major. The 26-year-old wins 80% service games on this surface, but manages a mere 23% break point conversion rate.

Popped off 🎉@alexeipopyrin takes down Emil Ruusuvuori 6-3 6-4 7-6(3) to reach the second round 🇦🇺#GoAussies pic.twitter.com/P3CmIfqjQL
— TennisAustralia (@TennisAustralia) August 26, 2025

Jannik Sinner vs Alexei Popyrin Head to Head Record

Alexei Popyrin has a 1-0 record in the head-to-head against Jannik Sinner. They faced one another at the 2021 Madrid Masters on clay. Popyrin surprised the Italian with a straight sets win.

Event	Round	Winner	Score
2021 Madrid	Round of 32	Alexei Popyrin	7-6(5) 6-2

Jannik Sinner vs Alexei Popyrin Career Comparison

Jannik Sinner	Category	Alexei Popyrin
1	Current Ranking	36
295-84	Career W-L Record	110-130
32-4	YTD W-L Record	17-18
20	Career Titles	3
2	YTD Titles	0
4	Grand Slams	0

Jannik Sinner vs Alexei Popyrin US Open 2025 Prediction

The power and depth of Popyrin will force Sinner to push slightly further away from the baseline as the match goes on. Only a practically flawless outing on serve will suffice for the Aussie – Sinner has a tendency to make early inroads and deny his opponents any chances at making a comeback into the encounter. Popyrin will have to mix things up with some slices, and accurately change direction before Sinner can take charge of rallies.

Prediction: Jannik Sinner in four sets.

Jannik Sinner vs Alexei Popyrin US Open 2025 Betting Odds

Sinner is a strong favourite in the pre-match betting market vs underdog Popyrin. According to the implied probability on the money line, Sinner has a 96% chance of advancing to the Third Round. Here are the odds (as per BetMGM):

Jannik Sinner Win: 1/25
Alexei Popyrin Win: 21/2

Total Games >30.5: 10/13
Total Games <30.5: 49/50
Total Sets <3.5: 12/25
Sinner -8.5 (Game Handicap): 23/20
Popyrin +9.5 (Game Handicap): 5/11
Sinner to Win 3-0: 1/2

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

(Image Credits: Robert Deutsch, Imagn Images)

Alexei Popyrin

ATP

Betting

Jannik Sinner

Tennis

US Open

US Open 2025

Sankalp Harikrishnan

A passionate sports fan through and through, I am currently pursuing my MA in Global Sports Journalism. I specialise in tennis and football writing at The Playoffs News, and I have prior experience working at EssentiallySports and Sportskeeda. Born and raised in Bengaluru, India, sport was my safe space right from my childhood. After trying my hand at multiple sports and representing my educational institutions in cricket, badminton and table tennis, I found sports media to be my calling.