2025 NFL Week 5 brings a fresh slate of matchups, with four teams on bye and the rest battling in critical early-season test, including heated divisional rivalries and cross-conference clashes. Last week’s stunners like the Giants’ upset over the Chargers, the Jaguars beating the 49ers, and the Falcons beating the Commanders, proved the NFL’s unpredictable nature, where underdogs can topple favorites in a heartbeat.
This week’s games, from Thursday’s primetime kickoff to Sunday’s London clash, promises more chaos. Injuries, rookie gambles, and desperate 1-3 squads add more intrigue, reminding fans why the NFL captivates your attention, as any play can happen on any given week. And that is why we watch the beautiful game.
Here are the best underdogs bets for teams playing on Week 5, according to BetMGM
The San Francisco 49ers can pull off the upset against the Rams thanks to their explosive offense firing on all cylinders despite the injury woes. Christian McCaffrey’s elite versatility could exploit LA’s average run defense which has always been the problem from them. Kyle Shanahan also edge 10-6 over Sean McVay, while 49ers’ defense (ranking 5th in the league) could pressure Stafford amid his own protection woes, and since he is not a dual-threat QB, it is not going to be easy.
Given below is the spread and the moneyline for the Rams vs 49ers game, according to BetMGM
| Teams | Spread | Total Points | Moneyline |
|---|---|---|---|
| 49ers | +7 (-115) | 46.5 (-115) | +260 |
| Rams | -7 (-105) | 46.5 (-105) | -325 |
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The Commanders are on the road to face the Chargers, and we believe that Washington can beat L.A. Jayden Daniels is expected to return from a knee sprain, bringing his dual-threat spark to an offense averaging 26.8 points per game. Washington’s elite rushing offense (sitting at 2nd) should be able to exploit LA’s defense and looking at the fact that the Chargers are coming off an humiliating defeat to the Giants, we believe the Commanders will take this one.
Given below is the moneyline and the spread for the Chargers vs Commanders game, according to BetMGM
| Teams | Spread | Total Points | Moneyline |
|---|---|---|---|
| Commanders | +2.5 (+100) | 48 (-110) | +130 |
| Chargers | -2.5 (-120) | 48 (-110) | -155 |
The Giants made the move to start Jaxson Dart over Russell Wilson, and it worked out beautifully against the L.A. Chargers, despite losing their WR Malik Nabers to an injury. Dart had a great game, completing 65 percent of his passes in the first game, and throwing for a TD without any INTs, along with 96.0 QB rating.
The Giants rank 17th in passing offense and 20th in overall offense compared to the Saints at 26th and 22nd. And while the Saints are the better overall defensive team, we think the Giants winning at least one game against a playoff team, compared to the Saints 0-4 record, the Giants may edge out the Saints.
Given below is the moneyline and the spread for the Saints vs Giants game, according to BetMGM
(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)
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