2025 NFL Week 11 MNF 49ers vs Panthers Player Props and Parlays

Monday Night Football ignites Levi’s Stadium as the San Francisco 49ers (7-4) host the upstart Carolina Panthers (6-5) on November 24, 2025, at 8:15 p.m. ET on ESPN. This 49ers vs Panthers game features two rising quarterbacks, that are trying to get their team to the playoffs this season. The Niners, fresh off at 41-22 demolition of Arizona, sit atop the NFC West with Brock Purdy’s efficient arm and a versatile offense averaging 28.6 points per game. Despite injuries plaguing this team, San Francisco’s defense has helped them win games, with the playoffs on the horizon.

Meanwhile, Carolina, leading the NFC South, stunned Atlanta 30-27 in OT last week behind Bryce Young’s franchise-record 448-yard masterpiece. Rookie WE Tetairoa McMillan and RB Chuba Hubbard fuels the team’s offense. With 49ers favored to win, this NFC clash could reshape playoff races-prime time drama awaits.

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49ers vs Panthers Same Game Parlays

Here are a couple of same-game parlays for the MNF game between the 49ers vs Panthers as per FanDuel.

Same Game Parlay 1

Brock Purdy 275+ passing yards (+158) + Bryce Young 250+ passing yards (+250) + George Kittle 50+ receiving yards (-152)

Parlay Payout: Wager $100 to win $855.95

Brock Purdy has played in three games this season, dealing with injuries. However, he has been elite, throwing for 200+ yard in each games and crossing the 275+ yards mark two times already. We expect a tough game against the Panthers, when the game gets close, Purdy has shown a tendency to attempt more passes.

Bryce Young had an insane game against Atlanta last week with 448 passing yards, breaking the franchise record for most yards in a single game, crossing Cam Newton’s 432-yard output set in 2011. While he’s still developing his game, Young may have found something in the last game. And looking at the 49ers 28th ranked pass defense, Young has a great chance to once again put great numbers, above 250+ yards.

George Kittle is starting to find his rhythm this season, and has posted back-to-back games above 50 yards, with 84 yards against the Rams and 67 yards last week against the Cardinals. The Panthers have a mediocre pass defense that gives up 212.8 yards per game, and the 49ers should be exploit the holes that they have, allowing Kettle to cross 50 yards again for third consecutive game.

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Same Game Parlay 2

Tetairoa McMillan 70+ receiving yards (+104) + Christian McCaffrey 50+ receiving yards (+122) + Ricky Pearsall 50+ receiving yards (+136)

Parlay Payout: Wager $100 to win $808.77

Tetairoa McMillan has 4 games this season, where he’s crossed 70+ yards, and has done it very efficiently. There have been multiple games where he’s nearly crossed the 70+ yard mark and looking at the 49ers’ extremely vulnerable pass defense, giving up 249.1 yards a game and ranking 28th in the league, McMillan can certainly cross this threshold once again.

Christian McCaffrey has been the heavy lifter for the 49ers’ offense this season and has been the most consistent player for them. McCaffrey’s dual-threat ability has been on full display this season and has 9 games above 50+ receiving yards. He’s played the role of a receiver and a running back and we expect him to cross 50 yards once again tonight against the Panthers.

Ricky Pearsall has only played in five games this season, with injuries keeping him out for many games. However, in these 5 games, he has two 100+ yards performance and 3 game overall where he’s crossed the 50 yard mark. With defenses trying to contain George Kittle and Christian McCaffrey, Pearsall may be open to catch passes from Purdy.

49ers vs Panthers Best Player Props

Here are some of the best player props for this week’s game between 49ers vs Panthers as per FanDuel.

Christian McCaffrey anytime TD scorer: -370
Rico Dowdle anytime TD scorer: -140
George Kittle anytime TD scorer: +120

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Christian McCaffrey has been utilized as a rusher and a pass target this season. With multiple injuries to key players, McCaffrey has stepped up big for the 49ers, showing why he is still one of the best running backs in the game. Whether it’s by air or by running McCaffrey has totaled 4 receiving TDs and 6 rushing TDs this season, and has solely kept the 49ers’ offense going.

Rico Dowdle may get a TD in this game as he can exploit San Francisco’s vulnerabilities in their red zone defense which ranks 16th, and a scoring defense that has already allowed 30 TDs this season. Dowdle has a tendency to explode at any given moment, as we saw in the game against Miami where he crossed 200+ yard mark.

George Kittle is a threat to score at any given moment, as in just 6 games he’s scored 5 TDs, and has been on a two game streak where he’s gotten at least one TD. Kittle’s return has proved that he is still one of the best tight ends in the NFL, and even with less touches he’s still been extreme effective.

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The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

Eric Divakaran

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I cover the National Football League and things cannot get better than that. I always dreamed to play football or basketball professionally since I’m built like a Running Back. But now that I can’t, since I’m technically in the “Unc” age, I thought why not pick a career in sports industry? So here I am, doing what I love, and hoping that the Commanders win the Super Bowl. I give love to players when it’s due, but can be critical about their performances at the same time. Enough about me, now let my articles do all the talking.