{"id":636255,"date":"2025-10-12T13:25:56","date_gmt":"2025-10-12T12:25:56","guid":{"rendered":"https:\/\/theplayoffs.news\/en\/?p=636255"},"modified":"2025-10-12T13:25:58","modified_gmt":"2025-10-12T12:25:58","slug":"nfl-week-6-predictions-underdog-picks-odds-for-all-week-6-including-nfl-sunday-games-sunday-night-football","status":"publish","type":"post","link":"https:\/\/theplayoffs.news\/en\/nfl-week-6-predictions-underdog-picks-odds-for-all-week-6-including-nfl-sunday-games-sunday-night-football\/","title":{"rendered":"NFL Week 6 Predictions \u2013 Predictions, Underdog Picks and Odds for All Week 6 NFL Sunday Games Including Chiefs vs Lions Sunday Night Football"},"content":{"rendered":"

As NFL Week 6 kicks off this Sunday, the league’s landscape continues to shift with injuries, breakout performances, and strategic showdowns that are reshaping divisions. Teams are hitting their strides, or stumbling, midway through the season, where every game carries more stakes for playoff positioning. <\/p>

In Week 5 we witnessed some upsets, like the Jaguars vs Chiefs game, where rising contenders are now clashing with established powerhouses. This NFL <\/a>season has also gotten us some under-the-radar talents emerging, and coaches adapting on the fly. Week 6’s Sunday Night Football features a prime time clash between the Chiefs and the Lions, which will gather all the attention and the eyes. However, there’s many more games that we will discuss today and who may potentially come out on top. Stay tuned for what promises to be a pivotal weekend in pro football. <\/p>

NFL Week 6 Predictions and Odds for All the Teams Playing on Sunday<\/h2>

Listed below are all the odds and predictions for the games taking place on Sunday, October 12, 2025, as per BetMGM<\/strong><\/a><\/p>

New York Jets vs Denver Broncos <\/h3>

To start off Sunday NFL <\/a>games the New York Jets will take on the Denver Broncos at Northumberland Development Project at London. The Jets, under Aaron Glenn, are off to a 0-5 start to their season so far. Despite changing Aaron Rodgers for Justin Fields, nothing has changed for them even after 5 weeks of NFL football. While the Denver Broncos, 3-2 for the season, shocked the world with a huge win against the Philadelphia Eagles who were undefeated before meeting them. <\/p>

Teams<\/th>Spread<\/th>Total Points<\/th>Moneyline<\/th><\/tr><\/thead>
Broncos <\/td>-7 (-110)<\/a><\/td>43.5 (-110)<\/td>-375<\/td><\/tr>
Jets<\/td>+7 (-110)<\/a><\/td>43.5 (-110)<\/td>+300<\/td><\/tr><\/tbody><\/table><\/figure>

Prediction<\/strong>: Broncos win the game <\/p>

Pittsburgh Steelers vs Cleveland Browns<\/h3>

The Pittsburgh Steelers who are 3-1 for the season, and are coming off a bye week, will take on the Cleveland Browns. The Steelers, under Aaron Rodgers, have lost only to the Seahawks so far and their offense has been stellar to start the season. Meanwhile, the Browns (1-4) recently traded Joe Flacco to the Bengals and are putting their trust and faith and two rookie QBs in Dillon Gabriel (starter) and backup QB Shedeur Sanders. <\/p>

Teams<\/th>Spread<\/th>Total Points<\/th>Moneyline<\/th><\/tr><\/thead>
Browns<\/td>+6 (-110)<\/a><\/td>38.5 (-110)<\/td>+225<\/td><\/tr>
Steelers<\/td>-6 (-110)<\/a><\/td>38.5 (-110)<\/td>-275<\/td><\/tr><\/tbody><\/table><\/figure>

Prediction<\/strong>: Steelers win the game<\/p>

Indianapolis Colts vs Arizona Cardinals<\/h3>

The Indianapolis Colts will take on the Arizona Cardinals<\/a> for Week 6 action. The Colts have been red hot to start the season (4-1), thanks to Daniel Jones’ breakout year he’s having this season, along with Jonathan Taylor’s rushing game. While the Cardinals are 2-3 for the season, struggling to gather momentum with their QB Kyler Murray leading the way.<\/p>

Teams<\/th>Spread<\/th>Total Points<\/th>Moneyline<\/th><\/tr><\/thead>
Cardinals <\/td>+7.5 (-110)<\/a><\/td>47.5 (-110)<\/td>+300<\/td><\/tr>
Colts<\/td>-7.5 (-110)<\/a><\/td>47.5 (-110)<\/td>-375<\/td><\/tr><\/tbody><\/table><\/figure>

Prediction<\/strong>: Colts win the game <\/p>

Miami Dolphins vs Los Angeles Chargers<\/h3>

The Miami Dolphins will host the Los Angeles Chargers for their Week 6 action. The Dolphins (1-4) are off to a rough start this season, with WR Tyreek Hill’s leg injury that will sideline him for the rest of the year. While the Los Angeles Chargers, after starting out hot, have lost back-to-back games against the Giants and the Commanders.<\/p>

Teams<\/th>Spread<\/th>Total Points<\/th>Moneyline<\/th><\/tr><\/thead>
Chargers <\/td>-4 (-110)<\/a><\/td>43.5 (-110)<\/td>-210<\/td><\/tr>
Dolphins<\/td>+4 (-110)<\/a><\/td>43.5 (-110)<\/td>+170<\/td><\/tr><\/tbody><\/table><\/figure>

Prediction<\/strong>: Dolphins win the game<\/p>

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Play together 🤜🤛 #PhinsUp<\/a> pic.twitter.com\/QYwyUdjQxP<\/a><\/p>— Miami Dolphins (@MiamiDolphins) October 11, 2025<\/a><\/blockquote>