{"id":633766,"date":"2025-10-02T16:45:38","date_gmt":"2025-10-02T15:45:38","guid":{"rendered":"https:\/\/theplayoffs.news\/en\/?p=633766"},"modified":"2025-10-02T17:02:13","modified_gmt":"2025-10-02T16:02:13","slug":"nfl-spread-2025-nfl-week-5-spread-lines-and-betting-odds-for-all-32-teams","status":"publish","type":"post","link":"https:\/\/theplayoffs.news\/en\/nfl-spread-2025-nfl-week-5-spread-lines-and-betting-odds-for-all-32-teams\/","title":{"rendered":"NFL Spread this Week – 2025 NFL Week 5 Spread, Lines and Betting Odds for All 32 Teams"},"content":{"rendered":"

Week 5 of the NFL <\/a>season comes with a slate of high-stakes battles, as teams look to solidify their early momentum or claw back from shaky starts. With the playoff picture slowly taking shape, every game carries weight where offenses are finding their rhythms, while defenses aim to disrupt. Expect various quarterback duels and teams battling to edge out the other for the top position in their respective divisions. <\/p>

Injuries and short weeks will add further chaos, which will now test the depth and coaching. From primetime showdowns to afternoon duels, fans can catch every moment of the action, with kickoffs starting Thursday and running through Monday Night. <\/p>

Which Teams Have a Bye Week in Week 5?<\/h2>

There are four teams that will not be active this week on the field, including the Chicago Bears, the Green Bay Packers, the Atlanta Falcons, and the Pittsburgh Steelers.<\/p>

NFL Week 5 Spreads <\/h2>

Heading into Week 5 of the NFL<\/a>, the Detroit Lions are the massive favorites in their matchup against the Cincinnati Bengals at -10.5<\/a> Closely followed by them are the Buffalo Bills, who after beating the Saints in Week 4, are now once again huge favorites against the New England Patriots in Week 5 with a spread of -8<\/a>. The Cardinals are also a huge favorite to beat the Tennessee Titans as the are 7.5-point<\/a> favorites over the Titans. Along with the Rams, a -8.5<\/a> favorite, to beat the 49ers on Thursday.<\/p>

Moneylines and Betting Odds for Week 5<\/h2>

As for the moneyline, the Lions are a staggering -600<\/a> favorites over the Bengals, the Buffalo Bills hold a -475<\/a> line, and the Cardinals are at -425<\/a>. The Rams are also a -450<\/a> favorite going against 49ers in Week 5. <\/p>

Now, let us take a look at the betting odds as per BetMGM<\/strong><\/a> for all week 4 matchups, along with the predictions.<\/p>

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For safe and reliable wagers, don’t miss our expert review of the best NFL betting platforms available online.<\/em><\/strong><\/a><\/p>

L.A. Rams (3-1) vs San Francisco 49ers (3-1)<\/h3>

The L.A Rams<\/a> will take on the San Francisco 49ers for Thursday Night Football’s NFC West action in Week 5. The Rams are coming off a win against the Colts, while the 49ers are coming off a loss against the Jacksonville Jaguars in Week 4. The 49ers hold the number one spot at NFC West, compared to the Rams at third. This matchup will decide who’s the top dog in their division.<\/p>

Teams<\/th>Spread<\/th>Total Points<\/th>Moneyline<\/th><\/tr><\/thead>
49ers<\/td>+8.5 (105)<\/a><\/td>44.5 (-110)<\/td>+350<\/td><\/tr>
Rams<\/td>-8.5 (105)<\/a><\/td>44.5 (-110)<\/td>-450<\/td><\/tr><\/tbody><\/table><\/figure>

Prediction: L.A. Rams win <\/strong><\/p>

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Hopped off the plane at LAX ✈️@united<\/a> | #FTTB<\/a> pic.twitter.com\/b7Re00GWKi<\/a><\/p>— San Francisco 49ers (@49ers) October 2, 2025<\/a><\/blockquote>