{"id":632452,"date":"2025-09-27T15:36:47","date_gmt":"2025-09-27T14:36:47","guid":{"rendered":"https:\/\/theplayoffs.news\/en\/?p=632452"},"modified":"2025-09-27T15:36:53","modified_gmt":"2025-09-27T14:36:53","slug":"nfl-week-4-saints-vs-bills-predictions-preview-betting-odds-2025-26-season","status":"publish","type":"post","link":"https:\/\/theplayoffs.news\/en\/nfl-week-4-saints-vs-bills-predictions-preview-betting-odds-2025-26-season\/","title":{"rendered":"New Orleans Saints vs Buffalo Bills Preview, Betting Odds, and Predictions &#8211; NFL 2025-26 Season Week 4"},"content":{"rendered":"<h2 class=\"wp-block-heading\">New Orleans Saints vs Buffalo Bills Preview, Betting Odds, and Predictions for the 2025-26 NFL Season Week 4<\/h2><p>The Bills Mafia is set to make some noise in this week 4 Saints vs Bills matchup at Highmark Stadium in Western New York. Buffalo is cruising along well with a perfect 3-0 start to its season, whereas the Saints are still searching for their first win with a 0-3 record.&nbsp;<\/p><h2 class=\"wp-block-heading\">Recommended bets and updated odds<\/h2><figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th class=\"has-text-align-center\" data-align=\"center\">Recommended Bets<\/th><th class=\"has-text-align-center\" data-align=\"center\">FanDuel<\/th><th class=\"has-text-align-center\" data-align=\"center\">BetMGM<\/th><\/tr><\/thead><tbody><tr><td class=\"has-text-align-center\" data-align=\"center\">Josh Allen over 1.5 passing touchdowns<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>-166<\/a><\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-betmgm-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>-167<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Bills cover 15.5-point spread<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>-110<\/a><\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-betmgm-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>-110<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Total Points Under 48.5<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>-188<\/a><\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-betmgm-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>-122<\/a><\/td><\/tr><\/tbody><\/table><\/figure><h2 class=\"wp-block-heading\">Analysis and Rationale<\/h2><p>Josh Allen has 5 passing touchdowns in his first three <a href=\"https:\/\/theplayoffs.news\/en\/nfl\/\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>games<\/a>. Moreover, the Saints&rsquo; defense has allowed 7 passing touchdowns in three games, which makes this bet worth considering.&nbsp;<\/p><p>Buffalo&rsquo;s offense has put up plenty of points in all three of its games so far. While the defense has conceded many points to the Ravens, they limited the Jets to just 10. The Saints&rsquo; offense has struggled quite a bit to score.&nbsp;<\/p><p>The total points under <a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>48.5<\/a> looks like a good bet based on the fact that the Saints&rsquo; offense has struggled to put points on the board even against the likes of the Arizona Cardinals. Going up against the Bills&rsquo; defense may prove even tougher. Buffalo has scored freely in its three games, but even then, the over seems a bit out of reach in this game.&nbsp;<\/p><figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"twitter-tweet\" data-width=\"500\" data-dnt=\"true\"><p lang=\"en\" dir=\"ltr\"><a href=\"https:\/\/twitter.com\/hashtag\/Bills?src=hash&amp;ref_src=twsrc%5Etfw\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>#Bills<\/a> Week 4 Uniform Combo:<br><br>Blue on White vs the <a href=\"https:\/\/twitter.com\/hashtag\/Saints?src=hash&amp;ref_src=twsrc%5Etfw\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>#Saints<\/a>!<br><br>&#128309;&#9898;&#65039;&#128309;&#9898;&#65039;<a href=\"https:\/\/twitter.com\/hashtag\/BuiltInBuffalo?src=hash&amp;ref_src=twsrc%5Etfw\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>#BuiltInBuffalo<\/a> | <a href=\"https:\/\/twitter.com\/hashtag\/GoBills?src=hash&amp;ref_src=twsrc%5Etfw\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>#GoBills<\/a> | <a href=\"https:\/\/twitter.com\/hashtag\/BillsMafia?src=hash&amp;ref_src=twsrc%5Etfw\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>#BillsMafia<\/a> <a href=\"https:\/\/t.co\/1nPeRiGmma\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>pic.twitter.com\/1nPeRiGmma<\/a><\/p>&mdash; Built in Buffalo (@BuiltInBuffalo_) <a href=\"https:\/\/twitter.com\/BuiltInBuffalo_\/status\/1970985462698475996?ref_src=twsrc%5Etfw\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>September 24, 2025<\/a><\/blockquote><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n<\/div><\/figure><h2 class=\"wp-block-heading\">New Orleans Saints vs Buffalo Bills Preview<\/h2><p>The <a href=\"https:\/\/www.neworleanssaints.com\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>New Orleans Saints<\/a> are coming into their week 4 matchup without a win. Their last game was against the Seattle Seahawks, in which they lost by a big margin (44-13). Offensively, the Saints have struggled to score points, while the defense was decent in the first couple of weeks.&nbsp;<\/p><p>The <a href=\"https:\/\/www.buffalobills.com\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>Buffalo Bills<\/a>, on the other hand, are enjoying an excellent start to their season with important wins against the AFC juggernaut, the Baltimore Ravens, and divisional opponents, the Jets and Dolphins.&nbsp;<\/p><h2 class=\"wp-block-heading\">New Orleans Saints Best Bets &ndash; Over\/Under and Player Bets<\/h2><p>Below are some of the best player bets for the New Orleans Saints as <strong><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>sourced from FanDuel<\/a><\/strong>.<\/p><h3 class=\"wp-block-heading\">New Orleans Saints Over\/Under Bets<\/h3><figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th class=\"has-text-align-center\" data-align=\"center\">Over\/ Under Bets<\/th><th class=\"has-text-align-center\" data-align=\"center\">Over&nbsp;<\/th><th class=\"has-text-align-center\" data-align=\"center\">Under<\/th><\/tr><\/thead><tbody><tr><td class=\"has-text-align-center\" data-align=\"center\">Spencer Rattler Passing Yards<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>200.5 (-114)<\/a><\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>200.5 (-114)<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Alvin Kamara Rushing Yards<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>50.5 (-114)<\/a><\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>50.5 (-114)<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Chris Olave Receiving Yards<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>58.5 (-114)<\/a><\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>58.5 (-114)<\/a><\/td><\/tr><\/tbody><\/table><\/figure><p>\n\n\n            <div class=\"MvpBookmakerTable\" >\n                                                            <div class=\"MvpBookmakerTableTopBlock\">\n                    <div class=\"MvpBookmakerTableTopBlock-item MvpBookmakerTableTopBlock-item--flex2\">\n                                    <div class=\"MvpBookmakerTableLogo\" style=\"background-color: #1493ff\">\n                <img decoding=\"async\" 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data-cta-trk='{\"ctaBrand\":\"FanDuel\",\"ctaType\":\"Brand block\",\"ctaActivity\":\"sports\",\"ctaSubType\":\"main\"}'>\n                <!-- <div class=\"MvpBookmakerTableBonus-title\">Bonus offer<\/div> -->\n                <!-- <div class=\"MvpBookmakerTableBonus-ties\"><img decoding=\"async\" src=\"https:\/\/theplayoffs.news\/en\/wp-content\/plugins\/mvp\/assets\/img\/bookmaker_table\/bonus-ties.svg\" alt=\"ties\" \/><\/div> -->\n                <div class=\"MvpBookmakerTableBonus-content\">\n                    <div class=\"MvpBookmakerTableBonus-content-icon\">\n                        <img decoding=\"async\" src=\"https:\/\/theplayoffs.news\/en\/wp-content\/plugins\/mvp\/assets\/img\/bookmaker_table\/bonus.svg\" alt=\"ties\" \/>\n                    <\/div>\n                    <div class=\"MvpBookmakerTableBonus-content-main\">\n                        <div class=\"MvpBookmakerTableBonus-content-main-value\">$150<\/div>\n                        <div class=\"MvpBookmakerTableBonus-content-main-text hide-on-mobile\">\n                                                            Welcome offer                                                    <\/div>\n                        <div class=\"MvpBookmakerTableBonus-content-main-text MvpBookmakerTableBonus-content-main-text--leftAligned MvpBookmakerTableBonus-content-main-text--leftAligned--ltr hide-on-tablet hide-on-desktop\">\n                                                            Bet $5 & Get $150 in Bonus Bets                                                    <\/div>\n                    <\/div>\n                <\/div>\n            <\/a>\n                                <\/div>\n                                        <div class=\"MvpBookmakerTableTopBlock-separator hide-on-mobile\"><\/div>\n                    <div class=\"MvpBookmakerTableTopBlock-item\">\n                                    <div class=\"MvpBookmakerTableCtaAndCode\">\n                <div class=\"MvpBookmakerTableCtaAndCode-top\">\n                                                        <div class=\"bonus-code bonus-code--blurred\"\n                data-clipboard-text=\"FANDUVIP\"\n                data-url=\"\"\n                data-hash=\"c8a16207\"\n                data-parent-id=\"\"\n                data-identifier=\"FanDuel\"\n                data-cta-trk='{\"ctaBrand\":\"FanDuel\",\"ctaType\":\"Brand block\",\"ctaActivity\":\"sports\",\"ctaSubType\":\"reveal\"}'            >\n                                    <div class=\"bonus-code__title\">\n                                                    Click to reveal code                                            <\/div>\n                                <div class=\"bonus-code__content\">\n                    <div class=\"bonus-code__content__copied-text\">\n                        COPIED                    <\/div>\n                    <div\n                        class=\"bonus-code__content__value\"\n                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          <\/div>\n            <\/div>\n                                                    <a rel=\"nofollow\"\n                        target=\"_blank\"\n                        href=\"\"\n                        class=\"MvpBookmakerTableCtaAndCode-top-cta\"\n                        data-cta-trk='{\"ctaBrand\":\"FanDuel\",\"ctaType\":\"Brand block\",\"ctaActivity\":\"sports\",\"ctaSubType\":\"main\"}'>\n                        <span>Claim now<\/span>\n                        <img decoding=\"async\" src=\"https:\/\/theplayoffs.news\/en\/wp-content\/plugins\/mvp\/assets\/img\/bookmaker_table\/right-arrow-white.svg\" alt=\"arrow\" class=\"--ltr\" \/>\n                    <\/a>\n                <\/div>\n                            <\/div>\n                            <\/div>\n                <\/div>\n                                                                    <div class=\"MvpBookmakerTable-separator\"><\/div>\n            <div class=\"MvpBookmakerTableTANDC\">\n                New customers only. Must be 21+ in most jurisdictions, but 18+ in DC, KY, and WY. Offer is valid only in eligible regulated states\/jurisdictions and not available in AR; void where prohibited. First online real-money wager only; cashed-out or bonus-funded bets are excluded.            <\/div>\n                                                    <\/div>\n            \n\n\n\n<\/p><h3 class=\"wp-block-heading\">New Orleans Saints Best Player Bets<\/h3><p>Below are some of the best player bets for the New Orleans Saints as <strong><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>sourced from FanDuel<\/a><\/strong>.<\/p><ul class=\"wp-block-list\">\n<li>Spencer Rattler Interception: <a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>-168<\/a><\/li>\n\n\n\n<li>Alvin Kamara 60+ Rushing Yards: <a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>+144<\/a><\/li>\n\n\n\n<li>Rashid Shaheed 40+ Receiving Yards: <a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>+104<\/a><\/li>\n<\/ul><figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"twitter-tweet\" data-width=\"500\" data-dnt=\"true\"><p lang=\"en\" dir=\"ltr\">prep &#10004;&#65039; <a href=\"https:\/\/t.co\/1eSfEbxdIH\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>pic.twitter.com\/1eSfEbxdIH<\/a><\/p>&mdash; New Orleans Saints (@Saints) <a href=\"https:\/\/twitter.com\/Saints\/status\/1971305509908312142?ref_src=twsrc%5Etfw\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>September 25, 2025<\/a><\/blockquote><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n<\/div><\/figure><h2 class=\"wp-block-heading\">Buffalo Bills Best Bets &ndash; Over\/Under and Player Bets<\/h2><p>Here is a look at the over\/under and player bets for the Buffalo Bills <strong><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>as per FanDuel<\/a><\/strong>.<\/p><h3 class=\"wp-block-heading\">Buffalo Bills Over\/Under Bets<\/h3><figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th class=\"has-text-align-center\" data-align=\"center\">Over\/ Under Bets<\/th><th class=\"has-text-align-center\" data-align=\"center\">Over&nbsp;<\/th><th class=\"has-text-align-center\" data-align=\"center\">Under<\/th><\/tr><\/thead><tbody><tr><td class=\"has-text-align-center\" data-align=\"center\">Josh Allen Passing Yards<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>216.5 (-114)<\/a><\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>216.5 (-114)<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">James Cook Rushing Yards<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>74.5 (-114)<\/a><\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>74.5 (-114)<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Keon Coleman Total Receptions<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>3.5 (-102)<\/a><\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>3.5 (-130)<\/a><\/td><\/tr><\/tbody><\/table><\/figure><h3 class=\"wp-block-heading\">Buffalo Bills Best Player Bets<\/h3><p>Below are some of the best player bets for the Buffalo Bills as <strong><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>sourced from FanDuel<\/a><\/strong>.<\/p><ul class=\"wp-block-list\">\n<li>James Cook Anytime Touchdown Scorer: <a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>&ndash; 210<\/a><\/li>\n\n\n\n<li>Dalton Kincaid 4+ Receptions: <a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>-114<\/a><\/li>\n\n\n\n<li>James Cook 70+ Yards: <a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>-144<\/a><\/li>\n<\/ul><figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"twitter-tweet\" data-width=\"500\" data-dnt=\"true\"><p lang=\"en\" dir=\"ltr\">&#120279;&#120284;&#120279; &#120300;&#120290;&#120296; &#120286;&#120289;&#120290;&#120298;?: The <a href=\"https:\/\/twitter.com\/hashtag\/Bills?src=hash&amp;ref_src=twsrc%5Etfw\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>#Bills<\/a> defense is giving up the 2nd fewest pass yards per game.<br><br>131.3 yards allowed per game is second to the <a href=\"https:\/\/twitter.com\/hashtag\/Falcons?src=hash&amp;ref_src=twsrc%5Etfw\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>#Falcons<\/a> 131.0 yards per game.<a href=\"https:\/\/twitter.com\/hashtag\/BuiltInBuffalo?src=hash&amp;ref_src=twsrc%5Etfw\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>#BuiltInBuffalo<\/a> | <a href=\"https:\/\/twitter.com\/hashtag\/GoBills?src=hash&amp;ref_src=twsrc%5Etfw\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>#GoBills<\/a> | <a href=\"https:\/\/twitter.com\/hashtag\/BillsMafia?src=hash&amp;ref_src=twsrc%5Etfw\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>#BillsMafia<\/a> <a href=\"https:\/\/t.co\/eqL13fc7BF\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>pic.twitter.com\/eqL13fc7BF<\/a><\/p>&mdash; Built in Buffalo (@BuiltInBuffalo_) <a href=\"https:\/\/twitter.com\/BuiltInBuffalo_\/status\/1971209741138616580?ref_src=twsrc%5Etfw\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>September 25, 2025<\/a><\/blockquote><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n<\/div><\/figure><h2 class=\"wp-block-heading\">Week 4 Saints vs Bills Predictions<\/h2><p>On paper, this is one of the biggest mismatches this season. The Bills are firing on all cylinders, and reigning NFL MVP Josh Allen has continued to show why he is a player who needs to be taken seriously. Moreover, James Cook is providing support from the backfield that has eased Allen&rsquo;s workload.&nbsp;<\/p><p>The Saints are currently in a rebuild mode. Languishing in last place in the NFC South, New Orleans just doesn&rsquo;t have the capacity to go toe-to-toe with the heavyweights of the league, such as the Bills.&nbsp;<\/p><p><strong>Our Prediction: Bills to win and cover the spread.<\/strong><\/p><p>\n\n\n            <div class=\"MvpBookmakerTable\" >\n                                                            <div class=\"MvpBookmakerTableTopBlock\">\n                    <div class=\"MvpBookmakerTableTopBlock-item MvpBookmakerTableTopBlock-item--flex2\">\n                                    <div class=\"MvpBookmakerTableLogo\" style=\"background-color: #1493ff\">\n                <img decoding=\"async\" src=\"https:\/\/theplayoffs.news\/en\/wp-content\/uploads\/mm-business-data\/images\/brands\/9b4dabf72537-500-FanDuel.jpeg\" alt=\"FanDuel\">\n            <\/div>\n                                            <div class=\"MvpBookmakerTableTitleAndRate\">\n                <div class=\"MvpBookmakerTableTitleAndRate-title\">\n        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src=\"https:\/\/theplayoffs.news\/en\/wp-content\/plugins\/mvp\/assets\/img\/bookmaker_table\/check.svg\" alt=\"check\" \/><\/div>\n                        <div class=\"MvpBookmakerTablePros-item-text\">High total bonus ceiling<\/div>\n                    <\/div>\n                                    <div class=\"MvpBookmakerTablePros-item\">\n                        <div class=\"MvpBookmakerTablePros-item-check\"><img decoding=\"async\" src=\"https:\/\/theplayoffs.news\/en\/wp-content\/plugins\/mvp\/assets\/img\/bookmaker_table\/check.svg\" alt=\"check\" \/><\/div>\n                        <div class=\"MvpBookmakerTablePros-item-text\">Daily second-chance bet protection<\/div>\n                    <\/div>\n                                    <div class=\"MvpBookmakerTablePros-item\">\n                        <div class=\"MvpBookmakerTablePros-item-check\"><img decoding=\"async\" src=\"https:\/\/theplayoffs.news\/en\/wp-content\/plugins\/mvp\/assets\/img\/bookmaker_table\/check.svg\" alt=\"check\" \/><\/div>\n                        <div class=\"MvpBookmakerTablePros-item-text\">No promo code required<\/div>\n                    <\/div>\n                            <\/div>\n                            <\/div>\n                                                                <div class=\"MvpBookmakerTableTopBlock-separator\"><\/div>\n                        <div class=\"MvpBookmakerTableTopBlock-item MvpBookmakerTableTopBlock-item--flex0_75\">\n                                        <a href=\"\"\n                rel=\"nofollow\"\n                target=\"_blank\"\n                class=\"MvpBookmakerTableBonus\"\n                data-cta-trk='{\"ctaBrand\":\"FanDuel\",\"ctaType\":\"Brand block\",\"ctaActivity\":\"sports\",\"ctaSubType\":\"main\"}'>\n                <!-- <div class=\"MvpBookmakerTableBonus-title\">Bonus offer<\/div> -->\n                <!-- <div class=\"MvpBookmakerTableBonus-ties\"><img decoding=\"async\" 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Must be 21+ in most jurisdictions, but 18+ in DC, KY, and WY. Offer is valid only in eligible regulated states\/jurisdictions and not available in AR; void where prohibited. First online real-money wager only; cashed-out or bonus-funded bets are excluded.            <\/div>\n                                                    <\/div>\n            \n\n\n\n<\/p><h2 class=\"wp-block-heading\">Saints vs Bills Betting Odds and Spread<\/h2><p>The moneyline and spread show the Buffalo Bills are massive favorites in this matchup against the New Orleans Saints, <strong><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>as sourced from FanDuel<\/a><\/strong>.&nbsp;<\/p><figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th class=\"has-text-align-center\" data-align=\"center\"><\/th><th class=\"has-text-align-center\" data-align=\"center\">Moneyline<\/th><th class=\"has-text-align-center\" data-align=\"center\">Spread<\/th><th class=\"has-text-align-center\" data-align=\"center\">Total Points<\/th><\/tr><\/thead><tbody><tr><td class=\"has-text-align-center\" data-align=\"center\"><strong>New Orleans Saints<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>+870<\/a><\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>+15.5 (-110)<\/a><\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>O 48.5 (-104)<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\"><strong>Buffalo Bills<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>-1500<\/a><\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>-15.5 (-110)<\/a><\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>U 48.5 (-118)<\/a><\/td><\/tr><\/tbody><\/table><\/figure><p><em>The above odds are <\/em><strong><em><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>sourced from FanDuel<\/a><\/em><\/strong><em>. Use FanDuel to ace your betting game in all sports!<\/em><\/p><h2 class=\"wp-block-heading\">FAQs<\/h2><h3 class=\"wp-block-heading\">What is the over\/under for total points for the Saints vs Bills game?<\/h3><p>The over\/under for total points in the Saints vs Bills game is set at <a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>48.5<\/a>.<\/p><h3 class=\"wp-block-heading\">What is the point spread for the Saints vs Bills game on Sunday?<\/h3><p>The Bills come into the game as massive <a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>15.5-point<\/a> favorites over the Saints.<\/p><h3 class=\"wp-block-heading\">What is the moneyline for the Saints vs Bills game in week 2?<\/h3><p>The Bills are the favorites with a moneyline of <a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>-1500<\/a>, while the Saints are the underdogs at <a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-prono-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>+870<\/a>.<\/p><p><em>Mandatory Credit: Gregory Fisher-Imagn Images<\/em><\/p>\n<div class=\"mm-layout mm-layout-type-global mm-layout-slot4\">\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Its the undefeated Bills against the winless Saints in this week 4 game on Sunday!<\/p>\n","protected":false},"author":23,"featured_media":632522,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"page-betting.php","format":"standard","meta":{"_acf_changed":false,"_mux_skip_reasons":[],"footnotes":""},"categories":[2590],"tags":[9956,597,330,82,9962],"class_list":["post-632452","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nfl-predictions","tag-bills-vs-saints","tag-buffalo-bills","tag-new-orleans-saints","tag-nfl","tag-saints-vs-bills-predictions"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.8 - 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