{"id":631752,"date":"2025-09-23T07:48:37","date_gmt":"2025-09-23T06:48:37","guid":{"rendered":"https:\/\/theplayoffs.news\/en\/?p=631752"},"modified":"2025-09-23T11:20:50","modified_gmt":"2025-09-23T10:20:50","slug":"liverpool-vs-southampton-preview-betting-odds-predictions","status":"publish","type":"post","link":"https:\/\/theplayoffs.news\/en\/liverpool-vs-southampton-preview-betting-odds-predictions\/","title":{"rendered":"Liverpool vs Southampton Preview, Betting Odds and Predictions \u2013 23\/09\/25"},"content":{"rendered":"<p>Liverpool are set to kick off their EFL Cup campaign at Anfield against Championship side Southampton on Tuesday night. The Reds are entering the match in excellent form. They&rsquo;re sitting top of the Premier League table with a perfect start to their 2025-26 season.<\/p><p>Arne Slot&rsquo;s men have combined attacking flair with resilience. They&rsquo;ve scored consistently but showed occasional defensive lapses. Despite those setbacks, they remain unbeaten across all competitions, and Anfield has proven a fortress once again. Liverpool now aim to carry that momentum into the domestic cup competition.<\/p><figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"twitter-tweet\" data-width=\"500\" data-dnt=\"true\"><p lang=\"en\" dir=\"ltr\">Back under the Anfield lights to begin our <a href=\"https:\/\/twitter.com\/Carabao_Cup?ref_src=twsrc%5Etfw\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>@Carabao_Cup<\/a> campaign. &#128308; <a href=\"https:\/\/t.co\/mWvnktaIm0\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>pic.twitter.com\/mWvnktaIm0<\/a><\/p>&mdash; Liverpool FC (@LFC) <a href=\"https:\/\/twitter.com\/LFC\/status\/1970372557871493324?ref_src=twsrc%5Etfw\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>September 23, 2025<\/a><\/blockquote><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n<\/div><\/figure><h2 class=\"wp-block-heading\">Liverpool vs Southampton Best Bets<\/h2><figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td class=\"has-text-align-center\" data-align=\"center\"><strong>Bets<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\"><strong>Status<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\"><strong>Moneyline<\/strong><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Total Goals<\/td><td class=\"has-text-align-center\" data-align=\"center\">Over 3.5<\/td><td class=\"has-text-align-center\" data-align=\"center\">-130<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Total Shots<\/td><td class=\"has-text-align-center\" data-align=\"center\">Over 25.5<\/td><td class=\"has-text-align-center\" data-align=\"center\">-208<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Total Shots on Target<\/td><td class=\"has-text-align-center\" data-align=\"center\">Over 8.5<\/td><td class=\"has-text-align-center\" data-align=\"center\">-225<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Total Corners<\/td><td class=\"has-text-align-center\" data-align=\"center\">Under 7.5<\/td><td class=\"has-text-align-center\" data-align=\"center\">+330<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Liverpool Goalkeeper Total Saves<\/td><td class=\"has-text-align-center\" data-align=\"center\">Over 2.5<\/td><td class=\"has-text-align-center\" data-align=\"center\">+310<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Southampton Goalkeeper Total Saves<\/td><td class=\"has-text-align-center\" data-align=\"center\">Over 5.5<\/td><td class=\"has-text-align-center\" data-align=\"center\">+230<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Total Cards<\/td><td class=\"has-text-align-center\" data-align=\"center\">Under 3.5<\/td><td class=\"has-text-align-center\" data-align=\"center\">-250<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Penalties in the Game<\/td><td class=\"has-text-align-center\" data-align=\"center\">Yes<\/td><td class=\"has-text-align-center\" data-align=\"center\">+122<\/td><\/tr><\/tbody><\/table><\/figure><h2 class=\"wp-block-heading\">Liverpool vs Southampton Preview<\/h2><h3 class=\"wp-block-heading\">Liverpool<\/h3><p>Arne Slot is expected to rotate his squad, resting several key players who have featured heavily so far. Dominik Szoboszlai, Mohamed Salah, Ryan Gravenberch, Ibrahima Konate and Virgil van Dijk are all expected to sit out. Giorgi Mamardashvili should start in goal.<\/p><p>He should be supported by Joe Gomez and Giovanni Leoni in defence. Teenage midfielder Trey Nyoni is in contention to partner Wataru Endo. Meanwhile Federico Chiesa could operate on the right flank. Slot is likely to use the tie to test depth options to maintain freshness across the squad.<\/p><p><strong>Also Read: <a href=\"https:\/\/theplayoffs.news\/en\/lincoln-city-vs-chelsea-preview-betting-odds-predictions\/\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>Lincoln City vs Chelsea Preview, Betting Odds and Predictions &ndash; 23\/09\/25<\/a><\/strong><\/p><h3 class=\"wp-block-heading\">Southampton<\/h3><p>Southampton boss Will Still is expected to set his side up with a back three in an attempt to keep Liverpool at bay. Ronnie Edwards, Nathan Wood and Jack Stephens should feature in central defence. Flynn Downes missed the Hull clash through illness but may return to regain sharpness in midfield.<\/p><p>The Saints&rsquo; form has been underwhelming so far. They&rsquo;ve managed only one win from their last six matches. And they have also often struggled on the road. Nonetheless, last season&rsquo;s EFL Cup quarter-finalists will look to rediscover momentum against top-flight opposition.<\/p><h2 class=\"wp-block-heading\">Liverpool vs Southampton Over\/ Under Predictions<\/h2><h3 class=\"wp-block-heading\"><a href=\"https:\/\/theplayoffs.news\/en\/go-betmgm-sportsbetting-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>Total Goals Over 3.5 @ -130 as per BetMGM:<\/a><\/h3><p>Liverpool&rsquo;s attacking form this season supports expecting over 3.5 goals. They&rsquo;ve scored 14 goals in their first six matches across competitions. They&rsquo;ve also found the net in every Premier League game so far. Playing at home, the coach could opt for rotation.<\/p><p>Even so, still loaded with offensive talent, they are positioned to score freely. Southampton, from a lower division, have shown defensive frailties. They&rsquo;ve conceded heavily in recent fixtures. Thus, making a high-scoring clash probable. At <a href=\"https:\/\/theplayoffs.news\/en\/go-betmgm-sportsbetting-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>-130<\/a>, this line reflects the possible scoreline justifiably.&nbsp;<\/p><h2 class=\"wp-block-heading\">Liverpool vs Southampton Player Picks<\/h2><h3 class=\"wp-block-heading\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-sports-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>Federico Chiesa to score anytime @ +115 as per FanDuel:<\/a><\/h3><p>Federico Chiesa has delivered some encouraging early signs this season. He scored his first Premier League goal for Liverpool in the dramatic 4-2 win over Bournemouth. He netted late after coming off the bench. Some senior attackers will be set to rest in this game.<\/p><p>Hence, Chiesa could be pushed forward, especially on the right flank. Given that rotation, and his knack for impactful moments off the bench, <a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-sports-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>+115<\/a> offers decent value for him to score anytime against Southampton.<\/p><p>\n\n\n            <div class=\"MvpBookmakerTable\" >\n                                                            <div class=\"MvpBookmakerTableTopBlock\">\n                    <div class=\"MvpBookmakerTableTopBlock-item MvpBookmakerTableTopBlock-item--flex2\">\n                                    <div class=\"MvpBookmakerTableLogo\" style=\"background-color: #1493ff\">\n                <img decoding=\"async\" src=\"https:\/\/theplayoffs.news\/en\/wp-content\/uploads\/mm-business-data\/images\/brands\/9b4dabf72537-500-FanDuel.jpeg\" alt=\"FanDuel\">\n            <\/div>\n                                            <div class=\"MvpBookmakerTableTitleAndRate\">\n                <div class=\"MvpBookmakerTableTitleAndRate-title\">\n                    <div class=\"MvpBookmakerTableTitleAndRate-title-text\">\n                        FanDuel                    <\/div>\n                <\/div>\n                <div class=\"MvpBookmakerTableTitleAndRate-rate\">\n                            <div class=\"MvpRating\">\n                                    <div class=\"MvpRating-star\">\n                                                    <img decoding=\"async\"\n                                src=\"https:\/\/theplayoffs.news\/en\/wp-content\/plugins\/mvp\/\/assets\/img\/rating\/star_full.svg\"\n                                alt=\"Star full\"\n                            \/>\n                                            <\/div>\n                                    <div class=\"MvpRating-star\">\n                                                    <img decoding=\"async\"\n                                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class=\"MvpBookmakerTableBonus-title\">Bonus offer<\/div> -->\n                <!-- <div class=\"MvpBookmakerTableBonus-ties\"><img decoding=\"async\" src=\"https:\/\/theplayoffs.news\/en\/wp-content\/plugins\/mvp\/assets\/img\/bookmaker_table\/bonus-ties.svg\" alt=\"ties\" \/><\/div> -->\n                <div class=\"MvpBookmakerTableBonus-content\">\n                    <div class=\"MvpBookmakerTableBonus-content-icon\">\n                        <img decoding=\"async\" src=\"https:\/\/theplayoffs.news\/en\/wp-content\/plugins\/mvp\/assets\/img\/bookmaker_table\/bonus.svg\" alt=\"ties\" \/>\n                    <\/div>\n                    <div class=\"MvpBookmakerTableBonus-content-main\">\n                        <div class=\"MvpBookmakerTableBonus-content-main-value\">$150<\/div>\n                        <div class=\"MvpBookmakerTableBonus-content-main-text hide-on-mobile\">\n                                                            Welcome offer                                                    <\/div>\n                        <div class=\"MvpBookmakerTableBonus-content-main-text MvpBookmakerTableBonus-content-main-text--leftAligned MvpBookmakerTableBonus-content-main-text--leftAligned--ltr hide-on-tablet hide-on-desktop\">\n                                                            Bet $5 & Get $150 in Bonus Bets                                                    <\/div>\n                    <\/div>\n                <\/div>\n            <\/a>\n                                <\/div>\n                                        <div class=\"MvpBookmakerTableTopBlock-separator hide-on-mobile\"><\/div>\n                    <div class=\"MvpBookmakerTableTopBlock-item\">\n                                    <div class=\"MvpBookmakerTableCtaAndCode\">\n                <div class=\"MvpBookmakerTableCtaAndCode-top\">\n                                                        <div class=\"bonus-code bonus-code--blurred\"\n                data-clipboard-text=\"FANDUVIP\"\n                data-url=\"\"\n                data-hash=\"c8a16207\"\n                data-parent-id=\"\"\n                data-identifier=\"FanDuel\"\n                data-cta-trk='{\"ctaBrand\":\"FanDuel\",\"ctaType\":\"Brand block\",\"ctaActivity\":\"sports\",\"ctaSubType\":\"reveal\"}'            >\n                                    <div class=\"bonus-code__title\">\n                                                    Click to reveal code                                            <\/div>\n                                <div class=\"bonus-code__content\">\n                    <div class=\"bonus-code__content__copied-text\">\n                        COPIED                    <\/div>\n                    <div\n                        class=\"bonus-code__content__value\"\n                    >\n                                                                        <span  class=\"first-half\">\n                        F                    <\/span>\n                                    <span  class=\"first-half\">\n                        A                    <\/span>\n                                    <span  class=\"first-half\">\n                        N                    <\/span>\n                                    <span >\n                        D                    <\/span>\n                                    <span >\n                        U                    <\/span>\n                                    <span >\n                        V                    <\/span>\n                                    <span >\n                        I                    <\/span>\n                                    <span >\n                        P                    <\/span>\n                                                            <\/div>\n                                    <\/div>\n            <\/div>\n                                                    <a rel=\"nofollow\"\n                        target=\"_blank\"\n                        href=\"\"\n                        class=\"MvpBookmakerTableCtaAndCode-top-cta\"\n                        data-cta-trk='{\"ctaBrand\":\"FanDuel\",\"ctaType\":\"Brand block\",\"ctaActivity\":\"sports\",\"ctaSubType\":\"main\"}'>\n                        <span>Claim now<\/span>\n                        <img decoding=\"async\" src=\"https:\/\/theplayoffs.news\/en\/wp-content\/plugins\/mvp\/assets\/img\/bookmaker_table\/right-arrow-white.svg\" alt=\"arrow\" class=\"--ltr\" \/>\n                    <\/a>\n                <\/div>\n                            <\/div>\n                            <\/div>\n                <\/div>\n                                                                    <div class=\"MvpBookmakerTable-separator\"><\/div>\n            <div class=\"MvpBookmakerTableTANDC\">\n                New customers only. Must be 21+ in most jurisdictions, but 18+ in DC, KY, and WY. Offer is valid only in eligible regulated states\/jurisdictions and not available in AR; void where prohibited. First online real-money wager only; cashed-out or bonus-funded bets are excluded.            <\/div>\n                                                    <\/div>\n            \n\n\n\n<\/p><h3 class=\"wp-block-heading\"><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-sports-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>Alexander Isak to either score or assist anytime @ -270 as per FanDuel:<\/a><\/h3><p>Isak, Liverpool&rsquo;s big summer signing, hasn&rsquo;t fully settled yet. However, his attacking presence has already been noted. With games crowded due to Liverpool&rsquo;s fixture load, he is likely to get chances in forward positions.&nbsp;<\/p><p>Given injuries or rest for others, Isak may lead the line. And his opportunity to score or set up a goal is strong. At <a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-sports-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>-270<\/a>, this odds reflects both confidence in Liverpool&rsquo;s attack and Isak&rsquo;s potential impact when given minutes in big matches.<\/p><h2 class=\"wp-block-heading\">Liverpool vs Southampton<\/h2><h3 class=\"wp-block-heading\">Liverpool vs Southampton Predictions<\/h3><figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td class=\"has-text-align-center\" data-align=\"center\"><strong>Picks<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\"><strong>Moneyline<\/strong><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Alexander Isak to score first<\/td><td class=\"has-text-align-center\" data-align=\"center\">+290<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Alexander Isak to score anytime<\/td><td class=\"has-text-align-center\" data-align=\"center\">-210<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Federico Chiesa to assist anytime<\/td><td class=\"has-text-align-center\" data-align=\"center\">+140<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Rio Ngumoha to either score or assist<\/td><td class=\"has-text-align-center\" data-align=\"center\">-170<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Flynn Downes to see a card<\/td><td class=\"has-text-align-center\" data-align=\"center\">+240<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Nathan Wood to commit one foul or more<\/td><td class=\"has-text-align-center\" data-align=\"center\">-140<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\"><em>Odds via <strong><a href=\"https:\/\/theplayoffs.news\/en\/go-FanDuel-sports-us-en\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>FanDuel<\/a><\/strong><\/em><\/figcaption><\/figure><p><strong>Also Read: <a href=\"https:\/\/theplayoffs.news\/en\/levante-vs-real-madrid-preview-betting-odds-predictions\/\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>Levante vs Real Madrid Preview, Betting Odds and Predictions &ndash; 23\/09\/25<\/a><\/strong><\/p><p>The Reds should dominate possession, generate multiple scoring chances, and capitalize on Southampton&rsquo;s defensive lapses. It&rsquo;s true that Liverpool&rsquo;s defense has shown occasional wobbliness, having thrown away leads recently. However, they are unlikely to be kept off the scoresheet at home <a href=\"https:\/\/www.liverpoolfc.com\/news\/opposition-lowdown-southampton-3\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" class=\"trk-cta-link\" data-cta-trk='{\"ctaType\":\"Link\",\"ctaSubType\":\"main\"}'>in this game<\/a>.&nbsp;Southampton may manage a consolation goal, perhaps from counterattacks or set pieces.<\/p><h3 class=\"wp-block-heading\">Final Prediction: Liverpool 3-1 Southampton<\/h3><p>Liverpool&rsquo;s firepower at Anfield should be enough to pull clear with a convincing performance. Taking all this into account, a 3-1 win for Liverpool seems the likeliest outcome.<\/p><div class=\"schema-faq wp-block-yoast-faq-block\"><div class=\"schema-faq-section\" id=\"faq-question-1758148670742\"><strong class=\"schema-faq-question\"><strong>When and where is the Liverpool vs Southampton game?<\/strong><\/strong> <p class=\"schema-faq-answer\">The Liverpool vs Southampton EFL Cup clash is on September 23, 2025, at the Anfield Stadium, Liverpool, England.<\/p> <\/div> <div class=\"schema-faq-section\" id=\"faq-question-1758148976038\"><strong class=\"schema-faq-question\"><strong>What are the BetMGM betting odds for the Liverpool vs Southampton game?<\/strong><\/strong> <p class=\"schema-faq-answer\">Liverpool are favorites to win with a moneyline at -900, to draw at +750 and for Southampton to win at +1600.<\/p> <\/div> <div class=\"schema-faq-section\" id=\"faq-question-1758149146813\"><strong class=\"schema-faq-question\"><strong>Name some key player prop bets for the game from BetMGM<\/strong><\/strong> <p class=\"schema-faq-answer\">Hugo Ekitike to Score Anytime: +110<br>Federico Chiesa to Assist Anytime: +280<br>Alexander Isak to Either Score or Assist: -192<\/p> <\/div> <\/div>\n<div class=\"mm-layout mm-layout-type-global mm-layout-slot4\">\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Liverpool are set to kick off their EFL Cup campaign at Anfield against Championship side Southampton on Tuesday night. The Reds are entering the match in excellent form. They&rsquo;re sitting top of the Premier League table with a perfect start to their 2025-26 season. Arne Slot&rsquo;s men have combined attacking flair with resilience. They&rsquo;ve scored [&hellip;]<\/p>\n","protected":false},"author":30,"featured_media":631757,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"page-betting.php","format":"standard","meta":{"_acf_changed":false,"_mux_skip_reasons":[],"footnotes":""},"categories":[4038,3843],"tags":[4760,1181,9906,4346],"class_list":["post-631752","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-soccer","category-soccer-predictions","tag-efl-cup","tag-liverpool","tag-liverpool-vs-southampton","tag-southampton"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Liverpool vs Southampton Preview, Betting Odds and Predictions &ndash; 23\/09\/25 - The Playoffs<\/title>\n<meta name=\"description\" content=\"Get the latest preview, betting odds, and predictions for the Liverpool vs Southampton EFL Cup 2025-26 match to be held on September 23.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/theplayoffs.news\/en\/liverpool-vs-southampton-preview-betting-odds-predictions\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Liverpool vs Southampton Preview, Betting Odds and Predictions &ndash; 23\/09\/25 - 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